Telefon:
+49 (0)241 95 163 153
Fax:
+49 (0)241 95 163 155
E-Mail:
orders@antikoerper-online.de

GZMB Antikörper

Dieses Maus Monoklonal-Antikörper erkennt spezifisch GZMB in FACS. Er zeigt eine Reaktivität gegenüber Human und Non-Human Primate und wurde in 3+ Publikationen erwähnt.
Produktnummer ABIN1302451

Kurzübersicht für GZMB Antikörper (ABIN1302451)

Target

Alle GZMB Antikörper anzeigen
GZMB (Granzyme B (GZMB))

Reaktivität

  • 183
  • 55
  • 27
  • 12
  • 4
  • 3
  • 3
  • 1
  • 1
Human, Non-Human Primate

Wirt

  • 99
  • 92
  • 3
Maus

Klonalität

  • 107
  • 87
Monoklonal

Konjugat

  • 104
  • 17
  • 8
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GZMB Antikörper ist unkonjugiert

Applikation

  • 93
  • 83
  • 44
  • 44
  • 30
  • 24
  • 20
  • 18
  • 14
  • 13
  • 13
  • 10
  • 6
  • 6
  • 5
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS)

Klon

CLB-GB11
  • Verwendungszweck

    Anti-Granzyme B Purified

    Spezifität

    The mouse monoclonal antibody CLB-GB11 recognizes granzyme B, a 31 kDa serine protease expressed intracellularly in activated Tc cells and NK cells.

    Kreuzreaktivität (Details)

    Human, Non-Human Primates

    Aufreinigung

    Purified by protein-A affinity chromatography.

    Reinheit

    > 95 % (by SDS-PAGE)

    Immunogen

    Human NK cell line YT-INDY-derived granzyme B

    Isotyp

    IgG1
  • Applikationshinweise

    Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Konzentration

    1 mg/mL

    Buffer

    Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Do not freeze.
  • Rissoan, Duhen, Bridon, Bendriss-Vermare, Péronne, de Saint Vis, Brière, Bates: "Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells." in: Blood, Vol. 100, Issue 9, pp. 3295-303, (2002) (PubMed).

    Tak, Spaeny-Dekking, Kraan, Breedveld, Froelich, Hack: "The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)." in: Clinical and experimental immunology, Vol. 116, Issue 2, pp. 366-70, (1999) (PubMed).

    Spaeny-Dekking, Hanna, Wolbink, Wever, Kummer, Kummer, Swaak, Middeldorp, Huisman, Froelich, Hack: "Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 7, pp. 3610-6, (1998) (PubMed).

  • Target

    GZMB (Granzyme B (GZMB))

    Andere Bezeichnung

    Granzyme B

    Hintergrund

    Granzyme B,Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.,GZMB, HLP, CTLA1, SECT

    Gen-ID

    3002

    UniProt

    P10144

    Pathways

    Apoptose, Caspase Kaskade in der Apoptose
Sie sind hier:
Chat with us!