GZMB Antikörper
Kurzübersicht für GZMB Antikörper (ABIN1302451)
Target
Alle GZMB Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
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Verwendungszweck
- Anti-Granzyme B Purified
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Spezifität
- The mouse monoclonal antibody CLB-GB11 recognizes granzyme B, a 31 kDa serine protease expressed intracellularly in activated Tc cells and NK cells.
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Kreuzreaktivität (Details)
- Human, Non-Human Primates
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Aufreinigung
- Purified by protein-A affinity chromatography.
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Reinheit
- > 95 % (by SDS-PAGE)
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Immunogen
- Human NK cell line YT-INDY-derived granzyme B
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Isotyp
- IgG1
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Applikationshinweise
- Flow cytometry: Recommended dilution: 1-4 μg/mL. Intracellular staining.
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Konzentration
- 1 mg/mL
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Buffer
- Tris buffered saline (TBS), pH 8.0, 15 mM sodium azide
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Handhabung
- Do not freeze.
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Lagerung
- 4 °C
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Informationen zur Lagerung
- Store at 2-8°C. Do not freeze.
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Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells." in: Blood, Vol. 100, Issue 9, pp. 3295-303, (2002) (PubMed).
: "The levels of soluble granzyme A and B are elevated in plasma and synovial fluid of patients with rheumatoid arthritis (RA)." in: Clinical and experimental immunology, Vol. 116, Issue 2, pp. 366-70, (1999) (PubMed).
: "Extracellular granzymes A and B in humans: detection of native species during CTL responses in vitro and in vivo." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 160, Issue 7, pp. 3610-6, (1998) (PubMed).
: "
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Subtractive hybridization reveals the expression of immunoglobulin-like transcript 7, Eph-B1, granzyme B, and 3 novel transcripts in human plasmacytoid dendritic cells." in: Blood, Vol. 100, Issue 9, pp. 3295-303, (2002) (PubMed).
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- GZMB (Granzyme B (GZMB))
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Andere Bezeichnung
- Granzyme B
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Hintergrund
- Granzyme B,Granzyme B is a serine protease that is expressed in cytoplasmic granules of cytotoxic T lymphocytes and NK cells. Vectorial secretion of perforin and granzymes is responsible for their granule-mediated cytotoxicity. Granzyme B plays a pivotal role in the induction of apoptosis in the target cells by activation of caspases. Moreover, granzyme B was reported to cleave directly alpha-tubulin, leading to perturbation of microtubule networks during the induced cell death.,GZMB, HLP, CTLA1, SECT
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Gen-ID
- 3002
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UniProt
- P10144
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Pathways
- Apoptose, Caspase Kaskade in der Apoptose
Target
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