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GLI2 Antikörper (Internal Region)

This anti-GLI2 antibody (ABIN129624) is a Rabbit Polyclonal antibody detecting GLI2 in WB, ELISA, IHC. Suitable for Mouse.
Rockland
Produktnummer ABIN129624
Hersteller Produkt- Nr.: 600-401-695

Kurzübersicht für GLI2 Antikörper (Internal Region) (ABIN129624)

Target

Alle GLI2 Antikörper anzeigen
GLI2 (GLI Family Zinc Finger 2 (GLI2))

Reaktivität

  • 28
  • 12
  • 6
  • 1
Maus

Wirt

  • 28
  • 2
Kaninchen

Klonalität

  • 28
  • 2
Polyklonal

Konjugat

  • 20
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser GLI2 Antikörper ist unkonjugiert

Applikation

  • 18
  • 11
  • 11
  • 6
  • 4
  • 3
  • 2
  • 1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
  • Bindungsspezifität

    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Internal Region

    Hersteller Produkt- Nr.

    600-401-695

    Hersteller

    Rockland

    Verwendungszweck

    Gli2 Antibody

    Kreuzreaktivität (Details)

    This affinity purified antibody is directed against mouse Gli-2 protein.

    Produktmerkmale

    Synonyms: rabbit anti-Gli-2 antibody, Gli 2, Gli2, zinc finger protein GLI2, Tax helper protein antibody, Thp antibody

    Aufreinigung

    The product was affinity purified from monospecific antiserum by immunoaffinity chromatography.

    Sterilität

    Sterile filtered

    Immunogen

    Immunogen: This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to amino acids from an internal region of Mouse Gli-2.

    Immunogen Type: Conjugated Peptide

    Isotyp

    IgG
  • Applikationshinweise

    Immunohistochemistry Dilution: 2 μg/mL to 20 μg/mL

    Application Note: This antibody has been tested for use in ELISA, immunohistochemistry and western blot.  Specific conditions for reactivity should be optimized by the end user. See figure legend for expectations by WB and IHC.  Multiple splice variants have been reported for this protein.

    Western Blot Dilution: 1:500 - 1:2,000

    ELISA Dilution: 1:15,000 - 1:60,000

    Other: User Optimized

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1.02 mg/mL

    Buffer

    Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

    Stabilizer: None

    Preservative: 0.01 % (w/v) Sodium Azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Lagerung

    4 °C,-20 °C

    Informationen zur Lagerung

    Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

    Haltbarkeit

    12 months
  • Guntur, Reinhold, Cuellar, Naski: "Conditional ablation of Pten in osteoprogenitors stimulates FGF signaling." in: Development (Cambridge, England), Vol. 138, Issue 7, pp. 1433-44, (2011) (PubMed).

  • Target

    GLI2 (GLI Family Zinc Finger 2 (GLI2))

    Andere Bezeichnung

    Gli2

    Hintergrund

    Background: Gli-2 (also known as Zinc Finger Protein Gli-2, GLI-Kruppel family member GLI-2 or Tax helper protein) belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors that bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling, and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. Gli-2 is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes: Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, pre-axial polydactyly type IV, and postaxial polydactyly types A1 and B. Anti-Gli 2 Antibody is useful for researchers interested in transcription factor activities, DNA binding, and chromatin binding research.

    Gen-ID

    14633, 124487481

    UniProt

    Q8K0K3

    Pathways

    Hedgehog Signalweg, Dopaminergic Neurogenesis
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