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GLI3 Antikörper (GLI Family Zinc Finger 3) AA 41-57 Primary Antibody

GLI3 Reaktivität: Human IHC, ELISA, WB Wirt: Kaninchen Polyclonal unconjugated
Pubmed (1 reference)
Produktnummer ABIN129623
$658.50
Zzgl. Versandkosten $45.00 und $20.00 Trockeneis
100 μg
local_shipping Lieferung nach: Vereinigte Staaten von Amerika
Lieferung in 1 bis 2 Werktagen
  • Target Alle GLI3 Antikörper anzeigen
    GLI3
    Bindungsspezifität
    • 8
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 41-57
    Reaktivität
    • 55
    • 26
    • 20
    • 5
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 39
    • 9
    • 8
    Kaninchen
    Klonalität
    • 41
    • 15
    Polyklonal
    Konjugat
    • 29
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GLI3 Antikörper ist unkonjugiert
    Applikation
    • 27
    • 27
    • 11
    • 8
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
    Kreuzreaktivität
    Schimpanse, Squirrel Monkey (Saimiri spec.), Xenopus laevis, Huhn, Hund, Wachtel
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Immunogen
    This affinity purified antibody was produced from monospecific rabbit serum by repeated immunizations with a synthetic peptide corresponding to amino acids 41-57 of human Gli-3 protein.
    Isotyp
    IgG
  • Applikationshinweise
    This antibody has been tested for use in ELISA, immunohistochemistry and western blot.  Specific conditions for reactivity should be optimized by the end user. Detection of Gli-3 by western blot may be enhanced if nuclear extracts are used instead of whole cell lysates as the expression/abundance of Gli-3 is likely to be low. Furthermore, Gli3 expression is likely to be developmentally regulated and induced, making it difficult to detect in whole tissue homogenates.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.0 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Hehemann, Kalmanek, Choe, Dynda, Hu, Quek, Harrington, Stupp, McVary, Podlasek: "Sonic hedgehog regulation of human rhabdosphincter muscle:Potential implications for treatment of stress urinary incontinence." in: Neurourology and urodynamics, Vol. 37, Issue 8, pp. 2551-2559, (2019) (PubMed).

  • Target
    GLI3
    Andere Bezeichnung
    Gli-3 (GLI3 Produkte)
    Synonyme
    ACLS, GCPS, GLI3-190, GLI3FL, PAP-A, PAPA, PAPA1, PAPB, PHS, PPDIV, xgli3, AI854843, AU023367, Bph, Pdn, Xt, add, im:7142603, GLI3, GLI family zinc finger 3, GLI family zinc finger 3 L homeolog, GLI-Kruppel family member GLI3, GLI3, Gli3, gli3.L, gli3
    Hintergrund
    Gli-3 (also known as Zinc Finger Protein Gli-3 or GLI-Kruppel family member GLI-3) belongs to the GLI C2H2-type zinc-finger protein family and contains 5 C2H2-type zinc fingers. Gli-3 is very important for normal limb and brain development and is implicated in the transduction of Shh signal. Gli-3 is a nuclear protein expressed in a wide variety of normal adult tissues, including lung, colon, spleen, placenta, testis, and myometrium. Defects in Gli-3 are the cause of Greig cephalo-poly-syndactyly syndrome (GCPS); an autosomal dominant disorder-affecting limb and cranio-facial development.  Two isoforms of human Gli-3 have been reported.  One is the full-length protein at ~170-190kDa and the other is a truncated isoform at ~80kDa.
    Synonyms: Gli-3, Zinc Finger Protein Gli-3, GLI-Kruppel family member GLI-3
    Gen-ID
    2737, 119393899
    UniProt
    P10071
    Pathways
    Hedgehog Signalweg
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