MAPT Antikörper (Isoform 13, N-Term)

Produktnummer ABIN126938

Der Maus Monoklonal anti-MAPT Antikörper wird verwendet zum Nachweis von MAPT in Proben von Human. Er wurde validiert für WB, IP und IHC (p).

Kurzübersicht für MAPT Antikörper (Isoform 13, N-Term) (ABIN126938)

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MAPT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: C45

Produktdetails anti-MAPT Antikörper

Bindungsspezifität: Isoform 13, N-Term

Produktmerkmale: Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, PHF-tau, Neurofibrillary tangle protein,Paired helical filament-tau

Aufreinigung: Affinity Purified

Immunogen: Synthetic peptide corresponding to the N-terminus of of the longest isoform of Human Tau.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Blot: 1/1000. Immunoprecipitation: 1/500. Immunohistochemistry: 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: PBS containing 50 % Glycerol, 1 % BSA and 0.02 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C/-80 °C

Informationen zur Lagerung: Store the antibody undiluted at -20 °C or for long term storage (in aliquots) at -70 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Andere Bezeichnung: MAPT / tau

Hintergrund: Tau, a microtubule-binding protein which serves to stabilize microtubules in growing axons, is found to be hyperphosphorylated in paired helical filaments (PHF), the major fibrous component of neurofibrillary lesions associated with Alzheimers disease. Hyperphosphorylation of Tau is thought to be the critical event leading to the assembly of PHF. Six Tau protein isoforms have been identified, all of which are phosphorylated by GSK3. This presents the possibility that miscues in GSK3 signaling contribute to the onset of Alzheimers disease.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau

UniProt: P10636

Pathways: MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size