Calreticulin Antikörper

Produktnummer ABIN126927

Der Maus Monoklonal anti-Calreticulin Antikörper (Klon S75) (ABIN126927) detektiert spezifisch Calreticulin in WB, IP und IHC (p). Dieser Antikörper reagiert spezifisch mit Proben aus Human und Affe.

Kurzübersicht für Calreticulin Antikörper (ABIN126927)

Target: Calreticulin (CALR)

Reaktivität: Human, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Calreticulin Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: S75

Produktdetails anti-Calreticulin Antikörper

Spezifität: The antibody recognizes a 63 kDa Calreticulin on SDS-PAGE Immunoblots.

Produktmerkmale: Synonyms: CRP55, Calregulin, HACBP, ERp60, grp60, CALR, CRTC

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: Calreticulin-maltose binding fusion protein

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: PBS containing 1 mg/mL BSA, 0.02 % Thimerosal and 50 % Glycerol

Konservierungsmittel: Thimerosal (Merthiolate)

Vorsichtsmaßnahmen: This product contains thimerosal (merthiolate): a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody at -20 °C or For long term storage, aliquot and refreeze at -70 °C. Avoid repeated freezing and thawing.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu Calreticulin

Target: Calreticulin (CALR)

Andere Bezeichnung: Calreticulin

Hintergrund: Calreticulin is a calcium binding protein found in abundance in the endoplasmic reticulum and the sarcoplasmic reticulum. Like many other ER proteins, it has the conserved ER retention KDEL (Lys-Asp-Glu-Leu) sequence at its C-terminus. Calreticulin has also been detected in the nucleus and nuclear envelop. Recent studies suggest that this soluble ER protein has a multifunctional role as it appears to be involved in calcium storage and regulation as well as having a molecular chaperone activity. Studies also suggest its involvement in certain autoimmune diseases. Consistence with its multiple functions the calreticulin molecule appears to have a zonal character. The protein has both high and low affinity calcium binding sites.Synonyms: CALR, CRP55, CRTC, Calregulin, ERp60, HACBP, grp60

Gen-ID: 811

UniProt: P27797

Pathways: Retinoic Acid Receptor Signaling Pathway, Intracellular Steroid Hormone Receptor Signaling Pathway, Regulation of Intracellular Steroid Hormone Receptor Signaling, Nuclear Hormone Receptor Binding, ER-Nucleus Signaling, Unfolded Protein Response