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GPR65 Antikörper

GPR65 Reaktivität: Human, Maus IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN122422
  • Target Alle GPR65 Antikörper anzeigen
    GPR65 (G Protein-Coupled Receptor 65 (GPR65))
    Reaktivität
    • 27
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 27
    Kaninchen
    Klonalität
    • 27
    Polyklonal
    Konjugat
    • 13
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser GPR65 Antikörper ist unkonjugiert
    Applikation
    • 8
    • 8
    • 7
    • 4
    • 3
    • 2
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Spezifität
    Reacts with T-Cell Death-Associated Gene 8 (family: GPCR, subfamily: Lysophospholipid/Lysosphingolipid)
    Kreuzreaktivität (Details)
    Species reactivity (tested):Human.
    Aufreinigung
    Immunoaffinity Chromatography
    Immunogen
    Synthetic peptide - KLH conjugated
    Top Product
    Discover our top product GPR65 Primärantikörper
  • Applikationshinweise
    Immunohistochemistry with formalin fixed paraffin embedded tissues: 4-11 μg/mL Antigen retrieval: Steam slides in 0.01 M sodium citrate buffer, pH 6.0, at 99-100 °C for 20 min. Remove from heat and let stand at room temperature in buffer for 20 min. Rinse in 1x TBS with Tween (TBST) for 1 min. at room temperature.
    Other applications not tested.
    Optimal dilutions are dependent on conditions and should be determined by the user. Further Comments: This product was originally produced by MBL International.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    PBS containing 0.09 % Sodium Azide as preservative
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C/-80 °C
    Informationen zur Lagerung
    Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -70 °C for longer. Avoid repeated freezing and thawing.
    Shelf life: one year from despatch.
    Haltbarkeit
    12 months
  • Target
    GPR65 (G Protein-Coupled Receptor 65 (GPR65))
    Andere Bezeichnung
    GPR65 / Psychosine Receptor (GPR65 Produkte)
    Synonyme
    tdag8 antikoerper, htdag8 antikoerper, TDAG8 antikoerper, hTDAG8 antikoerper, Dig1 antikoerper, Gpcr25 antikoerper, Tdag8 antikoerper, G protein-coupled receptor 65 antikoerper, G-protein coupled receptor 65 antikoerper, GPR65 antikoerper, gpr65 antikoerper, Gpr65 antikoerper
    Hintergrund
    GPR65 (TDAG8), a Lysophospholipid/Lysosphingolipid Receptor, is a molecular target for psychosine, a toxic lipid formed by the breakdown of galactosylceramide (cerebroside). A build-up of psychosine, caused by the lack of galactosylceramidase, results in the death of the myelin-synthesizing cells, oligodendrocytes, which is associated with Krabbe disease. Recent evidence suggests that GPR65 is one of the proton-sensing GPCRs coupling to adenylyl cyclase and psychosine and its related lysosphingolipids behave as if they were antagonists against protein-sensing receptors, including TDAG8, GPR4 and OGR1 GPR65 has been reported in human in peripheral blood leukocytes, spleen, lymph node, and thymus. ESTs have been isolated from human B-cell/lung/testis, brain/lung/testis, pancreas/spleen, lung/spleen, leukocyte, embryo, kidney, liver/spleen, thyroid, and vessel libraries.Synonyms: G-protein coupled receptor 65, T-cell death-associated protein 8, TDAG8
    Gen-ID
    8477
    UniProt
    Q8IYL9
    Pathways
    cAMP Metabolic Process
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