SOCS3 Antikörper

Produktnummer ABIN120754

Produktdetails anti-SOCS3 Antikörper

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SOCS3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Spezifität: This antibody SO1 reacts with SOCS3, an intracellular Cytokine Signaling Inhibitor.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: Full-length SOCS3 protein

Klon: 01-11-14

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: ELISA. Western blot: Use HeLa human cervix carcinoma cell line as positive control. Sample preparation: Resuspend approx. 50 mil. cells in 1 mLcold lysis buffer (1 % laurylmaltoside in 20 mM Tris/Cl, 100 mM NaCl pH 8.2, 50 mM NaF including protease inhibitor cocktail). Incubate 60 min on ice, centrifuge to remove cell debris. Mix lysate with reducing Laemmli SDS-PAGE sample buffer.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS with 15 mM Sodium Azide as preservative, approx. pH 7.4

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer. Avoid repeated freezing and thawing.
Shelf Life: one year from despatch.

Haltbarkeit: 12 months

Details zu SOCS3

Target: SOCS3 (Suppressor of Cytokine Signaling 3 (SOCS3))

Andere Bezeichnung: SOCS3 / CIS3 (SOCS3 Produkte)

Synonyme: socs3 antikoerper, fj09e12 antikoerper, zgc:56537 antikoerper, wu:fj09e12 antikoerper, MGC64393 antikoerper, MGC75749 antikoerper, xsocs3 antikoerper, MGC81248 antikoerper, atod4 antikoerper, cis3 antikoerper, cish3 antikoerper, socs-3 antikoerper, ssi-3 antikoerper, ssi3 antikoerper, SOCS3 antikoerper, ATOD4 antikoerper, CIS3 antikoerper, Cish3 antikoerper, SOCS-3 antikoerper, SSI-3 antikoerper, SSI3 antikoerper, Cis3 antikoerper, EF-10 antikoerper, Ef10 antikoerper, Ssi3 antikoerper, Socs-3 antikoerper, Ssi-3 antikoerper, suppressor of cytokine signaling 3a antikoerper, suppressor of cytokine signaling 3 S homeolog antikoerper, suppressor of cytokine signaling 3 antikoerper, suppressor of cytokine signaling 3 L homeolog antikoerper, socs3a antikoerper, socs3.S antikoerper, socs3 antikoerper, socs3.L antikoerper, SOCS3 antikoerper, Socs3 antikoerper

Hintergrund: SOCS3 (suppressor of cytokine signaling 3), also known as CIS3 (cytokine-inducible SH2 protein 3) is a negative regulator of particular cytokine signaling pathways. SOCS3 is induced by a variety of cytokines and other stimuli, such as erythropoietin, leptin and lipopolysaccharides and inhibits tyrosinkinase activity of JAK kinases, or e.g. JNK phosphorylation. SOCS3 modulates cytokine-mediated and neoplastic-proliferative responses and is involved also in maintaining leukocytes in quiescent state until antigen stimulation.Synonyms: CIS-3, Cytokine-inducible SH2 protein 3, SOCS-3, SSI-3, SSI3, STAT-induced STAT inhibitor 3, Suppressor of cytokine signaling 3

Gen-ID: 9021

UniProt: O14543

Pathways: JAK-STAT Signalweg, Response to Growth Hormone Stimulus, Hepatitis C