Integrin Alpha2b Antikörper (PE)

Produktnummer ABIN119845

Dieser Ratte Monoklonal Antikörper erkennt spezifisch Integrin Alpha2b in FACS. Er zeigt eine Reaktivität gegenüber Maus.

Kurzübersicht für Integrin Alpha2b Antikörper (PE) (ABIN119845)

Target: Integrin Alpha2b (CD41)

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser Integrin Alpha2b Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: MWReg30

Produktdetails anti-Integrin Alpha2b Antikörper (PE)

Spezifität: This antibody recognises the integrin alpha IIb subunit CD41. Clone MWReg30 has been reported to inhibit PMA induced aggregation in vitro and to induce hypothermia in vivo. We recommend the use of SM2035A for use in functional studies.

Kreuzreaktivität (Details): Species reactivity (tested):Mouse.

Aufreinigung: Affinity Chromatography on Protein G.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: The Fc region of monoclonal antibodies may bind non-specifically to cells expressing low affinity fc receptors.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 1 mL distilled water

Konzentration: 0.1 mg/mL

Buffer: PBS containing 0.09 % Sodium Azide as preservative, 5 % Sucrose and 1 % BSA as stabilizer.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Details zu Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Andere Bezeichnung: CD41 / ITGA2B

Hintergrund: Integrin alpha 2b (CD41) is a calcium-dependent, noncovalently associated heterodimer and contains a heavy chain (GPIIb alpha) and a light chain (GPIIb beta) linked by a single disulfide bond. The Integrin alpha 2B chain interacts with the Integrin beta 3 subunit/CD61 to form the platelet glycoprotein complex, gpIIb/IIIa. It is expressed on platelets and megakaryocytes. Ligands for the gpIIb/IIIa heterodimer include fibrinogen, von Willebrand factor, fibronectin, vitronectin, and thrombospondin. The gpIIb/IIIa complex is the major Integrin on platelets and is important for platelet adhesion and aggregation. CD41 is expressed on platelets and megakaryocytes and forms a heterodimer with CD61. CD41/CD61 is important for platelet adhesion and aggregation.Synonyms: GP2B, GPalpha IIb, ITGAB, Integrin alpha-IIb, Platelet membrane glycoprotein IIb

Gen-ID: 16399

NCBI Accession: NP_034705

UniProt: Q9QUM0

Pathways: Integrin Complex