KIT Antikörper (PE)

Produktnummer ABIN119402

Der Maus Monoklonal Anti-KIT Antikörper wurde für FACS validiert. Er ist geeignet, KIT in Proben von Human, Affe und Rind (Kuh) zu detektieren.

Kurzübersicht für KIT Antikörper (PE) (ABIN119402)

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Reaktivität: Human, Affe, Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser KIT Antikörper ist konjugiert mit PE

Applikation: Flow Cytometry (FACS)

Klon: 104D2

Produktdetails anti-KIT Antikörper (PE)

Spezifität: This antibody recognises the CD117 cell surface antigen. Functionally CD117 is a receptor for stem cell factor, and has receptor tyrosine kinase activity.

Immunogen: MOLM-1 Megakaryocyte cell line.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: Use 20 μL of Neat antibody to label 10^6 cells in 100 μL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.2 mg/mL

Buffer: PBS, 0.09 % Sodium Azide, 0.2 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu KIT

Target: KIT (Mast/stem Cell Growth Factor Receptor (KIT))

Andere Bezeichnung: CD117 / C-Kit

Hintergrund: C-kit, also known as stem cell factor receptor, steel factor receptor or CD117 is classified as a type III receptor tyrosine kinase (RTK) belonging to the platelet-derived growth factor receptor subfamily. Binding of stem cell factor (SCF), known as c-kit ligand to c-kit initiate autophosphorylation of the receptor, subsequently leading to promotes a signal transduction cascade through Ras-Raf-MAP kinase cascade, phosphatidylinositol-3-kinase, src family kinases, and STATs. The role of c-kit includes maturation of hematopoietic and primordial germ cells precursors and melanocytes during embryonic development. In acute myeloid leukemia (AML), c-kit has been proposed to play a functional role, and becomes target molecule for drug development.Synonyms: KIT, Mast/stem cell growth factor receptor, Proto-Oncogene Tyrosine-Protein Kinase, SCFR

Gen-ID: 3815

NCBI Accession: NP_000213

UniProt: P10721

Pathways: RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Sensory Perception of Sound, Stem Cell Maintenance, Production of Molecular Mediator of Immune Response, Regulation of long-term Neuronal Synaptic Plasticity