CTLA4 Antikörper

Produktnummer ABIN118890

Dieses Anti-CTLA4-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von CTLA4 in FACS, Func, IHC (fro) und EIA. Geeignet für Human.

Kurzübersicht für CTLA4 Antikörper (ABIN118890)

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CTLA4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Functional Studies (Func), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon: BNI3

Produktdetails anti-CTLA4 Antikörper

Spezifität: Highly specific for CD152 (CTAL-4).

Immunogen: Human CTLA-4/human IgG heavy chain fusion protein (CTLA-4/Ig)

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Research studies by Microscopy or Flow cytometry, after in vitro activation of T cells with selected stimuli (Concanavalin A, or solid-phase fixed-CD3 + CD28 Mabs stimulation). Research studies on CTLA-4 expression on B cells and on CTLA-4 expression by Immunohistochemistry only on frozen tissue sections. Fluorescence microscopy or Flow cytometry: 2 μg/5x10e5 cells/test. Cytospin or immunohistochemistry on frozen tissue sections: Working concentration is 5-50 μg/mL.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 1 mL of distilled water.

Buffer: PBS, pH 7.2, containing 1 mg/mL BSA as stabilizer without preservatives

Konservierungsmittel: Without preservative

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu CTLA4

Target: CTLA4 (Cytotoxic T-Lymphocyte-Associated Protein 4 (CTLA4))

Andere Bezeichnung: CD152 / CTLA4

Hintergrund: The cytolytic T-lymphocyte-associated antigen 4 (CTLA-4) is a member of the Ig superfamily (1) and its extracellular domain exhibits a single Ig V-like region. It was originally identified as a fourth cDNA product, during a search for genes that were thought to be specifically expressed in cytotoxic T lymphocytes (1). CTLA-4 has a molecular weight close to 45 kDa (2). It is mainly expressed as a monomer (4), but may also be expressed as a disulfide-linked homodimer (2,3). CTLA-4 belongs to the CD28 receptor family (4,5).Synonyms: CTLA-4, Cytotoxic T-lymphocyte protein 4, Cytotoxic T-lymphocyte-associated antigen 4

Gen-ID: 1493

NCBI Accession: NP_001032720

UniProt: P16410

Pathways: Cancer Immune Checkpoints