CD3 Antikörper

Produktnummer ABIN1177372

Dieser Maus Monoklonal Antikörper erkennt spezifisch CD3 in FACS und Func. Er zeigt eine Reaktivität gegenüber Human und wurde in 1 Publikation erwähnt.

Kurzübersicht für CD3 Antikörper (ABIN1177372)

Target: CD3

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD3 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Functional Studies (Func)

Klon: UCHT1

Produktdetails anti-CD3 Antikörper

Marke: BD Pharmingen™

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Isotyp: IgG1 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Referenzen für anti-CD3 Antikörper (ABIN1177372)

Beverley, Callard: "Distinctive functional characteristics of human "T" lymphocytes defined by E rosetting or a monoclonal anti-T cell antibody." in: European journal of immunology, Vol. 11, Issue 4, pp. 329-34, (1981) (PubMed).

Details zu CD3

Target: CD3

Andere Bezeichnung: CD3

Hintergrund: The UCHT1 monoclonal antibody specifically binds to the human CD3epsilon-chain, a 20-kDa subunit of the CD3/T cell antigen receptor complex. CD3epsilon is expressed on 70-80% of normal human peripheral blood lymphocytes and 60-85% of thymocytes. Studies from the HLDA Workshop show that this antibody is mitogenic for CD3epsilon-positive cells when used in conjunction with costimulatory agents such as pokeweed mitogen or anti-CD28 antibody. CD3 plays a central role in signal transduction during antigen recognition. The UCHT1 antibody stains both surface and intracellular CD3epsilon unlike the other CD3 clone, HIT3a, that stains only extracellular CD3epsilon.
Synonyms: CD3e, CD3E, T3E, TCRE , T-cell surface antigen T3/Leu-4 epsilon

Pathways: T-Zell Rezeptor Signalweg, Ubiquitin Proteasome Pathway