CD40 Ligand Antikörper

Produktnummer ABIN1177324

Dieses Maus Monoklonal-Antikörper erkennt spezifisch CD40 Ligand in FACS und Func. Er zeigt eine Reaktivität gegenüber Human, Rhesusaffen, Pavian und Cynomolgus und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für CD40 Ligand Antikörper (ABIN1177324)

Target: CD40 Ligand (CD40LG)

Reaktivität: Human, Rhesusaffen, Pavian, Cynomolgus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD40 Ligand Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Functional Studies (Func)

Klon: TRAP1

Produktdetails anti-CD40 Ligand Antikörper

Marke: BD Pharmingen™

Aufreinigung: The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.

Sterilität: 0.2 μm filtered

Endotoxin-Niveau: Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.

Isotyp: IgG1 kappa

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1.0 mg/mL

Buffer: No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.

Referenzen für anti-CD40 Ligand Antikörper (ABIN1177324)

Fuleihan, Ramesh, Horner, Ahern, Belshaw, Alberg, Stamenkovic, Harmon, Geha: "Cyclosporin A inhibits CD40 ligand expression in T lymphocytes." in: The Journal of clinical investigation, Vol. 93, Issue 3, pp. 1315-20, (1994) (PubMed).

Gray, Dullforce, Jainandunsing: "Memory B cell development but not germinal center formation is impaired by in vivo blockade of CD40-CD40 ligand interaction." in: The Journal of experimental medicine, Vol. 180, Issue 1, pp. 141-55, (1994) (PubMed).

Nishioka, Lipsky: "The role of CD40-CD40 ligand interaction in human T cell-B cell collaboration." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 153, Issue 3, pp. 1027-36, (1994) (PubMed).

Details zu CD40 Ligand

Target: CD40 Ligand (CD40LG)

Andere Bezeichnung: CD154

Hintergrund: Reacts with CD40 ligand (CD40L), a 39 kDa type II membrane glycoprotein expressed on activated T cells. CD40-CD40L interaction plays a very important role in T cell-dependent B-cell proliferation, differentiation, and memory cell formation. Anti-CD40L mAb partially blocks T cell-B cell interaction affecting subsequent proliferation, differentiation, and memory cell formation. Anti-CD40L mAb partially blocks T cell-B cell interaction affecting subsequent proliferation, IL-2R expression and differentiation of B cells. In addition, blocking of CD40-CD40L interaction has been demonstrated with soluble CD40, resulting in the inhibition of immunoglobulin isotype switching. It has been reported that patients with X-linked hyper-IgM syndrome have defective expression of functional CD40L due to a defective gene that encodes CD40L.
Synonyms: CD40L

Pathways: NF-kappaB Signalweg, Production of Molecular Mediator of Immune Response, Cancer Immune Checkpoints