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HLA-ABC Antikörper

HLA-ABC Reaktivität: Human FACS, BR Wirt: Maus Monoclonal DX17 unconjugated
Produktnummer ABIN1177256
  • Target Alle HLA-ABC Antikörper anzeigen
    HLA-ABC
    Reaktivität
    • 71
    • 23
    • 16
    • 14
    • 13
    • 12
    • 11
    • 11
    • 8
    • 7
    • 7
    • 6
    • 1
    • 1
    • 1
    Human
    Wirt
    • 60
    • 9
    • 3
    Maus
    Klonalität
    • 62
    • 9
    Monoklonal
    Konjugat
    • 33
    • 8
    • 6
    • 6
    • 4
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser HLA-ABC Antikörper ist unkonjugiert
    Applikation
    • 56
    • 19
    • 18
    • 11
    • 10
    • 10
    • 8
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Blocking Reagent (BR)
    Marke
    BD Pharmingen™
    Aufreinigung
    The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
    Sterilität
    0.2 μm filtered
    Endotoxin-Niveau
    Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
    Immunogen
    Polyclonal Human NK Cell Line
    Klon
    DX17
    Isotyp
    IgG1 kappa
    Top Product
    Discover our top product HLA-ABC Primärantikörper
  • Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1.0 mg/mL
    Buffer
    No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
    Konservierungsmittel
    Azide free
    Lagerung
    4 °C
    Informationen zur Lagerung
    Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
  • Gumperz, Litwin, Phillips, Lanier, Parham: "The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor." in: The Journal of experimental medicine, Vol. 181, Issue 3, pp. 1133-44, (1995) (PubMed).

    Lanier, Gumperz, Parham, Melero, López-Botet, Phillips: "The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 7, pp. 3320-7, (1995) (PubMed).

    Morton, Kirsch, Nance, Evans, Korman, Strominger: "Orientation of loci within the human major histocompatibility complex by chromosomal in situ hybridization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 9, pp. 2816-20, (1984) (PubMed).

    Bach, Amos: "Hu-1: Major histocompatibility locus in man." in: Science (New York, N.Y.), Vol. 156, Issue 3781, pp. 1506-8 (PubMed).

  • Target
    HLA-ABC
    Andere Bezeichnung
    HLA-A/B/C (HLA-ABC Produkte)
    Synonyme
    HLAA antikoerper, major histocompatibility complex, class I, A antikoerper, HLA-A antikoerper
    Hintergrund
    The DX17 monoclonal antibody reacts with a monomorphic epitope expressed on all HLA (human leukocyte antigen) class I molecules examined. DX17 immunoprecipitates HLA class I heavy chains (45 kDa) and beta2-microglobulin (12kDa) from radiolabeled human cell lines. HLA is determined by a complex segment of the short arm of chromosome 6 and there are many human HLAs encoded in this segment. The antigenic agglomerate is called MHC, for major histocompatibility complex. Examples of class I loci are HLA-A, -B, and -C, which are serologically assayed, class II loci, e.g., HLA-D/DR and DC1, are tested by lymphocytotoxic methods.
    Pathways
    T-Zell Rezeptor Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cancer Immune Checkpoints
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