HLA-ABC (HLA-ABC) Antikörper

Details zu Produkt Nr. ABIN1177256, Anbieter: Anmelden zum Anzeigen
Antigen
  • HLAA
  • major histocompatibility complex, class I, A
  • HLA-A
Reaktivität
Human
148
40
35
24
18
16
15
15
9
8
8
4
4
3
3
Wirt
Maus
127
18
4
Klonalität (Klon)
Monoklonal ()
Konjugat
Unkonjugiert
16
14
11
5
5
4
4
4
3
3
3
3
3
3
3
1
1
1
Applikation
Blocking Reagent (BR), Flow Cytometry (FACS)
123
55
35
30
27
26
24
14
7
2
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Marke BD Pharmingen™
Immunogen Polyclonal Human NK Cell Line
Klon DX17
Isotyp IgG1, kappa
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Sterilität 0.2 μm filtered
Endotoxin-Niveau Endotoxin level is ≤ 0.01 EU/μg (≤ 0.001 ng/μg) of protein as determined by the LAL assay.
Andere Bezeichnung HLA-A/B/C (HLA-ABC Antibody Abstract)
Hintergrund The DX17 monoclonal antibody reacts with a monomorphic epitope expressed on all HLA (human leukocyte antigen) class I molecules examined. DX17 immunoprecipitates HLA class I heavy chains (45 kDa) and beta2-microglobulin (12kDa) from radiolabeled human cell lines. HLA is determined by a complex segment of the short arm of chromosome 6 and there are many human HLAs encoded in this segment. The antigenic agglomerate is called MHC, for major histocompatibility complex. Examples of class I loci are HLA-A, -B, and -C, which are serologically assayed, class II loci, e.g., HLA-D/DR and DC1, are tested by lymphocytotoxic methods.
Pathways T-Zell Rezeptor Signalweg, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1.0 mg/mL
Buffer No azide/low endotoxin: Aqueous buffered solution containing no preservative, 0.2μm sterile filtered.
Konservierungsmittel Azide free
Lagerung 4 °C
Informationen zur Lagerung Store undiluted at 4°C. This preparation contains no preservatives, thus it should be handled under aseptic conditions.
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-HLA-ABC (HLA-ABC) antibody (ABIN1177256) anti-HLA-ABC (HLA-ABC) antibody
Produkt verwendet in: Gumperz, Litwin, Phillips, Lanier, Parham: "The Bw4 public epitope of HLA-B molecules confers reactivity with natural killer cell clones that express NKB1, a putative HLA receptor." in: The Journal of experimental medicine, Vol. 181, Issue 3, pp. 1133-44, 1995 (PubMed).

Lanier, Gumperz, Parham, Melero, López-Botet, Phillips: "The NKB1 and HP-3E4 NK cells receptors are structurally distinct glycoproteins and independently recognize polymorphic HLA-B and HLA-C molecules." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 154, Issue 7, pp. 3320-7, 1995 (PubMed).

Morton, Kirsch, Nance, Evans, Korman, Strominger: "Orientation of loci within the human major histocompatibility complex by chromosomal in situ hybridization." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 81, Issue 9, pp. 2816-20, 1984 (PubMed).

Bach, Amos: "Hu-1: Major histocompatibility locus in man." in: Science (New York, N.Y.), Vol. 156, Issue 3781, pp. 1506-8, 1970 (PubMed).

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