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NGFR Antikörper (PE)

Dieses Maus Monoklonal-Antikörper erkennt spezifisch NGFR in FACS und ICFC. Er zeigt eine Reaktivität gegenüber Human, Non-Human Primate, Kaninchen, Cat und Frettchen und wurde in 4+ Publikationen erwähnt.
Produktnummer ABIN1176838

Kurzübersicht für NGFR Antikörper (PE) (ABIN1176838)

Target

Alle NGFR Antikörper anzeigen
NGFR (Nerve Growth Factor Receptor (NGFR))

Reaktivität

  • 207
  • 63
  • 54
  • 38
  • 29
  • 27
  • 26
  • 22
  • 12
  • 5
  • 4
  • 3
  • 3
  • 3
  • 2
  • 2
  • 2
  • 1
  • 1
Human, Non-Human Primate, Kaninchen, Cat, Frettchen

Wirt

  • 110
  • 104
  • 4
  • 1
Maus

Klonalität

  • 143
  • 76
Monoklonal

Konjugat

  • 98
  • 18
  • 12
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 7
  • 6
  • 6
  • 3
  • 2
  • 2
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser NGFR Antikörper ist konjugiert mit PE

Applikation

  • 117
  • 94
  • 88
  • 59
  • 44
  • 43
  • 28
  • 27
  • 21
  • 17
  • 15
  • 15
  • 12
  • 7
  • 7
  • 6
  • 6
  • 3
  • 3
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Flow Cytometry (FACS), Intracellular Flow Cytometry (ICFC)

Klon

NGFR5
  • Verwendungszweck

    Anti-Hu CD271 PE

    Spezifität

    The mouse monoclonal antibody NGFR5 (originally C34C) recognizes an epitope within ammino acids 1 - 160 of CD271/NGFR, a 75 kDa transmembrane glycoprotein of the TNFR superfamily.

    Keine Kreuzreaktivität

    Maus, Ratte

    Kreuzreaktivität (Details)

    Human, Non-Human Primates, Feline (Cat), Rabbit, Ferret

    Aufreinigung

    Purified antibody is conjugated with R-phycoerythrin (PE) under optimum conditions. Unconjugated antibody and free fluorochrome are removed by size-exclusion chromatography.

    Immunogen

    Purified CD271 protein isolated from human melanoma cell line A875

    Isotyp

    IgG1
  • Applikationshinweise

    Flow cytometry: The reagent is designed for analysis of human blood cells using 10 μL reagent / 100 μL of whole blood or 106 cells in a suspension. The content of a vial (1 ml) is sufficient for 100 tests. Extracellular and intracellular staining.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Rekonstitution

    No reconstitution is necessary.

    Buffer

    Stabilizing phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Do not freeze.
    Avoid prolonged exposure to light.

    Lagerung

    4 °C

    Informationen zur Lagerung

    Store at 2-8°C. Protect from prolonged exposure to light. Do not freeze.
  • Alpers, Hudkins, Ferguson, Johnson, Schatteman, Bothwell: "Nerve growth factor receptor expression in fetal, mature, and diseased human kidneys." in: Laboratory investigation; a journal of technical methods and pathology, Vol. 69, Issue 6, pp. 703-13, (1994) (PubMed).

    Thompson, Schatteman, Gown, Bothwell: "A monoclonal antibody against nerve growth factor receptor. Immunohistochemical analysis of normal and neoplastic human tissue." in: American journal of clinical pathology, Vol. 92, Issue 4, pp. 415-23, (1989) (PubMed).

    Schatteman, Gibbs, Lanahan, Claude, Bothwell: "Expression of NGF receptor in the developing and adult primate central nervous system." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 8, Issue 3, pp. 860-73, (1988) (PubMed).

    Marano, Dietzschold, Earley, Schatteman, Thompson, Grob, Ross, Bothwell, Atkinson, Koprowski: "Purification and amino terminal sequencing of human melanoma nerve growth factor receptor." in: Journal of neurochemistry, Vol. 48, Issue 1, pp. 225-32, (1987) (PubMed).

  • Target

    NGFR (Nerve Growth Factor Receptor (NGFR))

    Andere Bezeichnung

    CD271

    Hintergrund

    Nerve growth factor receptor,CD271 / NGFR, also known as p75NGFR or p75NTR, is a 75 kDa low affinity receptor for the NGF (nerve growth factor), BDNF (brain-derived growth factor), and other neurotrophins, such as NT3 and NT4/5. Unlike other members of the tumor necrosis factor receptor superfamily of transmembrane proteins, CD271 has unique intracellular domain structure (lacks catalytic activity) and downstream signaling partners. Triggered by its ligands CD271 affects growth, differentiation, migration and death of the nervous system cells.,TNFRSF16, NGFR, p75NTR, p75NGFR

    Gen-ID

    4804

    UniProt

    P08138

    Pathways

    NF-kappaB Signalweg, Neurotrophin Signalübertragung, Carbohydrate Homeostasis, Growth Factor Binding
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