DLL4 Antikörper

Produktnummer ABIN1169261

Es gibt 1 Publikation für dieses Produkt. Der Ratte Monoklonal anti-DLL4 Antikörper wird verwendet zum Nachweis von DLL4 in Proben von Maus. Er wurde validiert für FACS und ICC.

Kurzübersicht für DLL4 Antikörper (ABIN1169261)

Target: DLL4 (delta-Like 4 (DLL4))

Reaktivität: Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser DLL4 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: 9A1-5

Produktdetails anti-DLL4 Antikörper

Verwendungszweck: anti-DLL4 (mouse), mAb (9A1.5)

Spezifität: Recognizes mouse DLL4.

Produktmerkmale: Monoclonal Antibody. Recognizes mouse DLL4. Isotype: Rat IgG1kappa. Clone: 9A1.5. Applications: FACS, ICC. Liquid. In PBS containing 10 % glycerol and 0.02 % sodium azide. The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.

Aufreinigung: Purified from concentrated hybridoma tissue culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Immunogen: Recombinant mouse DLL4:Fc.

Isotyp: IgG1 kappa

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: In PBS containing 10 % glycerol and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: After opening, prepare aliquots and store at -20 °C.Avoid freeze/thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung:

+4°C

-20°C

Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-DLL4 Antikörper (ABIN1169261)

Fiorini, Ferrero, Merck, Favre, Pierres, Luther, MacDonald: "Cutting edge: thymic crosstalk regulates delta-like 4 expression on cortical epithelial cells." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 181, Issue 12, pp. 8199-203, (2008) (PubMed).

Details zu DLL4

Target: DLL4 (delta-Like 4 (DLL4))

Andere Bezeichnung: DLL4

Hintergrund:

Alternate Names/Synonyms: Delta-like Protein 4, Delta4

Product Description: The Notch ligand delta-like protein 4 (DLL4) is expressed highly and selectively within the arterial endothelium and has been shown to function as a ligand for Notch1 and Notch4. It is induced by VEGF as a negative feedback regulator and acts to prevent overexuberant angiogenic sprouting, promoting the timely formation of a well differentiated vascular network. DLL4-Notch1 signaling regulates the formation of appropriate numbers of tip cells to control vessel sprouting and branching in the mouse retina.

UniProt: Q9JI71

Pathways: Notch Signalweg