BTLA Antikörper

Produktnummer ABIN1169098

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch BTLA in FACS und ELISA. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für BTLA Antikörper (ABIN1169098)

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Reaktivität: Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser BTLA Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), ELISA

Klon: 6F4

Produktdetails anti-BTLA Antikörper

Spezifität: Recognizes human BTLA.

Kreuzreaktivität: Human

Aufreinigung: Purified from concentrated hybridoma tissue culture supernatant.

Reinheit: >95 % (SDS-PAGE)

Endotoxin-Niveau: <0.001EU/μg purified protein.

Immunogen: Ectodomain of human BTLA fused to human IgG Fc.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: In PBS containing 10 % glycerol.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short Term Storage: +4°C
Long Term Storage: -20°C
Stable for at least 1 year after receipt when stored at -20°C.

Haltbarkeit: 12 months

Referenzen für anti-BTLA Antikörper (ABIN1169098)

Cheung, Oborne, Steinberg, Macauley, Fukuyama, Sanjo, DSouza, Norris, Pfeffer, Murphy, Kronenberg, Spear, Ware: "T cell intrinsic heterodimeric complexes between HVEM and BTLA determine receptivity to the surrounding microenvironment." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 11, pp. 7286-96, (2009) (PubMed).

Cheung, Steinberg, Oborne, Macauley, Fukuyama, Sanjo, DSouza, Norris, Pfeffer, Murphy, Kronenberg, Spear, Ware: "Unconventional ligand activation of herpesvirus entry mediator signals cell survival." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 15, pp. 6244-9, (2009) (PubMed).

Details zu BTLA

Target: BTLA (B and T Lymphocyte Associated (BTLA))

Andere Bezeichnung: BTLA

Hintergrund: B and T lymphocyte associated (BTLA) is an Ig domain superfamily protein with cytoplasmic immunoreceptor tyrosine-based inhibitory motifs. The herpes virus entry mediator (HVEM), a member of the TNF receptor (TNFR) superfamily, can act as a molecular switch that modulates T cell activation by propagating positive signals from the TNF-related ligand LIGHT (TNFR superfamily 14), or inhibitory signals through the Ig superfamily member BTLA. The binding site on HVEM for BTLA is conserved in the orphan TNF receptor UL144, present in human CMV. UL144 binds BTLA, but not LIGHT, and inhibits T cell proliferation, selectively mimicking the inhibitory cosignaling function of HVEM.

UniProt: Q7Z6A9

Pathways: Cancer Immune Checkpoints