Thymidine Phosphorylase Antikörper

Produktnummer ABIN114826

Dieser Maus Monoklonal Antikörper detektiert spezifisch Thymidine Phosphorylase in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus.

Kurzübersicht für Thymidine Phosphorylase Antikörper (ABIN114826)

Target: Thymidine Phosphorylase (TYMP)

Reaktivität: Human, Ratte, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Thymidine Phosphorylase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: P-GF-44C

Produktdetails anti-Thymidine Phosphorylase Antikörper

Spezifität: This antibody is specific to a 55 kDa protein known as Platelet-Derived Endothelial Growth Factor (PD-ECGF), similar to thymidine phosphorylase (TP). Cellular localization: Cytoplasmic, Nuclear.

Aufreinigung: Purified

Immunogen: A recombinant full length human thymidine phophorylase (TP/PD-ECGF) protein.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Formalin-Fixed Paraffin Embedded Sections: Use a dilution of1/25-1/75 in an ABC method (30 minutes at room temperature). Western blotting: 1/50-1/100. Recommended Positive Control: Breast carcinoma.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Thymidine Phosphorylase

Target: Thymidine Phosphorylase (TYMP)

Hintergrund: Platelet - derived endothelial growth factor (PD-ECGF), same as thymidine phosphorylase (TP) or gliostatin. In the presence of inorganic orthophosphate, it catalyses the reversible phospholytic cleavage of thymidine and deoxyuridine to their corresponding bases and 2-deoxyribose-1-phosphate. It is both chemotactic and mitogenic for endothelial cells and a non-heparin binding angiogenic factor present in platelets. It is also involved in transformation of fluoropyrimidines, cytotoxic agents used in the treatment of a variety of malignancies, into active cytotoxic metabolites. High levels of TP/PD-ECGF are observed in cancer patients. High intra-cellular levels of TP/PD-ECGF are associated with increased chemosensitivity to such antimetabolites.Synonyms: ECGF1, Gliostatin, PD-ECGF, Platelet-derived endothelial cell growth factor, TdRPase

Gen-ID: 1890

NCBI Accession: NP_001107227

UniProt: P19971

Pathways: Signaling Events mediated by VEGFR1 and VEGFR2