Ceruloplasmin Antikörper

Produktnummer ABIN113276

Der Schaf Polyklonal anti-Ceruloplasmin Antikörper wird verwendet zum Nachweis von Ceruloplasmin in Proben von Human. Er wurde validiert für EIA und IHC (fro).

Kurzübersicht für Ceruloplasmin Antikörper (ABIN113276)

Target: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Reaktivität: Human

Wirt: Schaf

Klonalität: Polyklonal

Konjugat: Dieser Ceruloplasmin Antikörper ist unkonjugiert

Applikation: Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro))

Produktdetails anti-Ceruloplasmin Antikörper

Spezifität: Recognizes Ceruloplasmin. This antibody shows minimal reactivity with related serum proteins.

Aufreinigung: Ammonium Sulphate Fractionation

Immunogen: Native human Ceruloplasmin

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry on Frozen Sections (1/20-1/200). ELISA (Has been used at dilutions as high as 1/400K in a simple ELISA with 0.1 μ/wellcoated).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 5.0 mg/mL

Buffer: PBS, pH 7.2 contaioning 0.09 % Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu Ceruloplasmin

Target: Ceruloplasmin (CP) (Ceruloplasmin (Ferroxidase) (CP))

Andere Bezeichnung: Ceruloplasmin

Hintergrund: Ceruloplasmin is a copper binding plasma glycoprotein consisting of a single polypeptide chain. It has a molecular weight of 132 kDa and occurs in plasma at a concentration of 150-500 mg/L. Although the physiological functions of Caeruloplasmin are not fully understood it is implicated in a number of possible functions. 95 % of plasma copper is bound to Caeruloplasmin, implying some involvement in copper transport. Caeruloplasmin has been described as both an oxidant and an antioxidant, its exact role or roles in this respect are not clear. Plasma levels of Caeruloplasmin are elevated after inflammation and trauma and it is therefore classified as an acute phase protein. The measurement of Caeruloplasmin in plasma is useful in the diagnosis of Wilson's disease, where levels are greatly reduced. Ceruloplasmin is extremely labile in plasma and rapidly degrades to 115 kDa and 19 kDa fragments. The age of plasma samples should therefore be taken into account when interpreting immunological analysis of ceruloplasmin.Synonyms: CP, Ferroxidase

Gen-ID: 1356

NCBI Accession: NP_000087

UniProt: P00450

Pathways: Transition Metal Ion Homeostasis