LDLR Antikörper

Produktnummer ABIN112187

Produktdetails anti-LDLR Antikörper

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Reaktivität: Human, Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LDLR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF)

Spezifität: Suitable for analysis of LDL Receptor function in patients with familial hypercholesterolemia. The antibody recognizes an epitope in the region of repeat #1 of the ligand binding region. Addition of 15 nM antibody results in inhibition of half-maximal LDL-binding (cf. Beisiegel et al. 1981). In Human normal fibroblasts the antibody detects the 160 kDa polypeptide (pI 4.3) and also in bovine adrenal gland (160 kDa, pI 4.6) of LDL receptors (Beisiegel et al. 1982).

Kreuzreaktivität (Details): Species reactivity (tested):Human and Bovine.

Aufreinigung: Affinity Chromatography

Immunogen: Purified Bovine adrenal cortex LDL Receptor

Klon: C7

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: FACS. Immunoblotting (Western blotting). Immunofluorescence (1/10-1/50).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Restore with 1.0 mL distilled water.

Buffer: Final solution contains PBS buffer, pH 7.4 with 0.5 % BSA as stabilizer

Handhabung: This product is photosensitive and should be protected from light

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE!

Details zu LDLR

Target: LDLR (Low Density Lipoprotein Receptor (LDLR))

Andere Bezeichnung: LDLR (LDLR Produkte)

Synonyme: FH antikoerper, FHC antikoerper, LDLCQ2 antikoerper, Hlb301 antikoerper, LDLRA antikoerper, LDLA antikoerper, LDL receptor-2 antikoerper, fhc antikoerper, ldlcq2 antikoerper, ldlr antikoerper, ldlr2-a antikoerper, LDL receptor 1 antikoerper, ldlr-a antikoerper, ldlr-b antikoerper, low density lipoprotein receptor antikoerper, low density lipoprotein receptor a antikoerper, low density lipoprotein receptor S homeolog antikoerper, low density lipoprotein receptor L homeolog antikoerper, LDLR antikoerper, Ldlr antikoerper, ldlra antikoerper, ldlr.S antikoerper, ldlr.L antikoerper

Hintergrund: The low density lipoprotein receptor (LDLR) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in this gene cause the autosomal dominant disorder, familial hypercholesterolemia.Synonyms: LDL receptor, LDLR, Low-density lipoprotein receptor

Gen-ID: 3949

NCBI Accession: NP_000518

UniProt: P01130

Pathways: Hepatitis C, Lipid Metabolism