KIT Ligand Antikörper (Extracellular Domain)
-
- Target Alle KIT Ligand (KITLG) Antikörper anzeigen
- KIT Ligand (KITLG)
-
Bindungsspezifität
- Extracellular Domain
-
Reaktivität
- Human, Primate
-
Wirt
- Maus
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser KIT Ligand Antikörper ist unkonjugiert
-
Applikation
- Western Blotting (WB), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- Spezifität
- This Monoclonal antibody hKL12 is specific for Stem Cell Factor (hSCF). hKL12 is useful for the detection of hSCF in tissues, isolated cells and for studying biological effects of Human Stem Cell Factor in vitro. Antigen distribution on Tissue sections: Bone marrow stromal cells, fibroblasts, and fetal liver cells express SCF. Keratinocytes stain positive.
- Kreuzreaktivität (Details)
-
Species reactivity (expected):Primates.
Species reactivity (tested):Human. - Aufreinigung
- Affinity Chromatography
- Immunogen
- Recombinant Human stem cell factor. Remarks: Recombinant Human SFC is an 18.4 kDa polypeptide containing 165 amino acid residues, corresponding to the sequence of the soluble form of SCF. The antigen is a 248 residue protein. The full-length transcript of the corresponding gene product includes a 25-amino acid secretory leader, a 189-amino acid extracellular domain, a 23-amino acid transmembrane region, and a 36-amino acid cytoplasmic tail. The epitope has not been further characterized.
- Klon
- HKL12
- Isotyp
- IgG1
- Top Product
- Discover our top product KITLG Primärantikörper
-
-
- Applikationshinweise
-
ELISA (0.15 μg/mL). Has been described to work in Wetsern blots and Immunohistochemistry.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user. - Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Rekonstitution
- Restore by adding 0.5 mL distilled water.
- Konzentration
- 0.4 mg/mL
- Buffer
- PBS, pH 7.2 containing 0.09 % Sodium Azide as preservative
- Konservierungsmittel
- Sodium azide
- Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Handhabung
- Avoid repeated freezing and thawing.
- Lagerung
- 4 °C/-20 °C
- Informationen zur Lagerung
- Prior to reconstitution store at 2-8 °C. Following reconstitution store the antibody at -20 °C.
-
- Target
- KIT Ligand (KITLG)
- Andere Bezeichnung
- KITLG / SCF (KITLG Produkte)
- Synonyme
- Xkl-1 antikoerper, Xsl antikoerper, Xsl-1 antikoerper, Xsl-2 antikoerper, steel antikoerper, KITLG antikoerper, SCF antikoerper, kitl antikoerper, kl-1 antikoerper, mgf antikoerper, scf antikoerper, FPH2 antikoerper, KL-1 antikoerper, Kitl antikoerper, MGF antikoerper, SF antikoerper, SHEP7 antikoerper, Clo antikoerper, Con antikoerper, Gb antikoerper, Kitlg antikoerper, Mgf antikoerper, SLF antikoerper, Sl antikoerper, blz antikoerper, contrasted antikoerper, 710-712 antikoerper, CSF antikoerper, KITL antikoerper, KIT ligand L homeolog antikoerper, KIT ligand antikoerper, kit ligand antikoerper, kitlg.L antikoerper, KITLG antikoerper, kitlg antikoerper, Kitl antikoerper, Kitlg antikoerper
- Hintergrund
- SCF is a transmembrane protein expressed as two alternatively spliced isoforms, either 220 or 248 amino acids, the former lacking a peptidase cleavage site. The cleavage site is responsible for the release of the soluble form of the protein from the cell surface. The first 164 or 165 residues of the extracellular domain comprise soluble SCF, which exists in solution as a noncovalently linked homodimer. Alone, SCF is a weakly proliferative stimulus but acts synergistically with numerous cytokines. SCF is important in germ cell developement, and an indispensable facor for mast cell proliferation an differentiation.Synonyms: KITL, Kit ligand, MGF, Mast cell growth factor, Stem cell factor, c-Kit ligand
- Gen-ID
- 4254
- NCBI Accession
- NP_000890
- UniProt
- P21583
- Pathways
- RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung
-