Integrin beta 2 Antikörper (Activation Site)

Produktnummer ABIN111898

Dieser Maus Monoklonal Antikörper detektiert spezifisch Integrin beta 2 in FACS, WB, IP und Func. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für Integrin beta 2 Antikörper (Activation Site) (ABIN111898)

Target: Integrin beta 2 (ITGB2)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Integrin beta 2 Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Western Blotting (WB), Immunoprecipitation (IP), Functional Studies (Func)

Klon: MEM-148

Produktdetails anti-Integrin beta 2 Antikörper

Bindungsspezifität: Activation Site

Spezifität: This antibody recognises an epitope on the CD18 Molecule that is hidden in the CD11/CD18 heterodimer on resting cells. Clone MEM-148 binds very weakly to resting peripheral blood leukocytes and strongly to all leukocytes upon cellular activation. The epitope recognised by MEM-148 is also exposed during dissociation of the CD11/CD18 by low pH .

Aufreinigung: Affinity chromatography on Protein G

Immunogen: Peripheral blood mononuclear cells.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow Cytometry. Immunoprecipitation. Western Blot: Non-reducing conditions.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Konservierungsmittel: Azide free

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody at -20 °C. Can be shipped at 2 - 8 °C.

Details zu Integrin beta 2

Target: Integrin beta 2 (ITGB2)

Andere Bezeichnung: CD18 / ITGB2

Hintergrund: CD18 is an integrin. Integrins are integral cell surface proteins composed of an alpha chain and a beta chain. A given chain may combine with multiple partners resulting in different integrins. For example, beta 2 combines with the alpha L chain to form the integrin LFA1, and combines with the alpha M chain to form the integrin Mac1. Integrins are known to participate in cell adhesion as well as cell surface mediated signalling. CD18 is expressed by most leucocytes. Defects in the CD18 gene result in leukocyte adhesion deficiency.Synonyms: 95 subunit beta, Cell surface adhesion glycoproteins LFA-1/CR3/p150, Complement receptor C3 subunit beta, Integrin beta-2, MFI7

Gen-ID: 3689

NCBI Accession: NP_000202

UniProt: P05107

Pathways: NF-kappaB Signalweg, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation