BMI1 Antikörper

Produktnummer ABIN1112825

Der Maus Monoklonal Anti-BMI1-Antikörper wurde für WB, IHC, IHC (p) und ICC validiert. Er ist geeignet, BMI1 in Proben von Maus zu detektieren.

Kurzübersicht für BMI1 Antikörper (ABIN1112825)

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Reaktivität: Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser BMI1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC)

Klon: P9

Produktdetails anti-BMI1 Antikörper

Immunogen: Recombinant Polycomb complex protein BMI-1 protein.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: WB (1:1000-5000), IHC-P (1:200), ICC (1:500). Other applications have not been tested. The optimal dilutions should be determined by end user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: TBS (pH7.4), 0.5% BSA, 40% Glycerol and 0.05% Sodium Azide.

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C after thawing (1 week). Aliquot and store at -20 °C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Haltbarkeit: 12 months

Details zu BMI1

Target: BMI1 (BMI1 Polycomb Ring Finger Oncogene (BMI1))

Andere Bezeichnung: Polycomb complex protein BMI-1

Hintergrund: BMI1 has been reported as an oncogene by regulating p16 and p19, which are cell cycle inhibitor genes. BMI1 knockout in mice results in defects in hematopoiesis, skeletal patterning, neurological functions, and development of the cerebellum. It is a component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. BMI1 is necessary for efficient self-renewing cell divisions of adult hematopoietic stem cells as well as adult peripheral and central nervous system neural stem cells. BMI1 is also thought to inhibit ageing in neurons through the suppression of p53.

Pathways: Zellzyklus, Autophagie