The antibody clone AA6 is specific to the 240 kDa Alpha-Fodrin molecule of all Mammalian nonerythroid cells and Chicken Alpha-Spectrin.
Kreuzreaktivität (Details)
Species reactivity (tested):Human, Rat, Chicken, Rabbit and Guinea Pig.
Aufreinigung
Ig Fraction
Immunogen
Chicken red blood cell membranes purified by hypotonic lysis and mechanical enucleation. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.
Fodrin is a universally expressed membrane associated cytoskeletal protein consisting of alpha and beta subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. Alpha Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases generating N terminal 150 kDa, C terminal 120 kDa, and 35 kDa major products. Cleavage of alpha Fodrin leads to membrane malfunction and cell shrinkage.Synonyms: Alpha-II spectrin, Fodrin alpha chain, SPTA2, Spectrin non-erythroid alpha chain