SPTAN1 Antikörper

Produktnummer ABIN1109119

Dieses Maus Monoklonal-Antikörper erkennt spezifisch SPTAN1 in WB, IHC (fro) und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für SPTAN1 Antikörper (ABIN1109119)

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SPTAN1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon: AA6

Produktdetails anti-SPTAN1 Antikörper

Spezifität: The antibody clone AA6 is specific to the 240 kDa Alpha-Fodrin molecule of all Mammalian nonerythroid cells and Chicken Alpha-Spectrin.

Kreuzreaktivität (Details): Species reactivity (tested):Human, Rat, Chicken, Rabbit and Guinea Pig.

Aufreinigung: Ig Fraction

Immunogen: Chicken red blood cell membranes purified by hypotonic lysis and mechanical enucleation. Hybridoma produced by fusion between myeloma cells and Balb/c spleen cells.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.09 % Sodium Azide, 1.0 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu SPTAN1

Target: SPTAN1 (Spectrin alpha Chain, Brain (SPTAN1))

Andere Bezeichnung: Spectrin alpha Chain (Brain) / SPTAN1

Hintergrund: Fodrin is a universally expressed membrane associated cytoskeletal protein consisting of alpha and beta subunits. The protein is important for maintaining normal membrane structure and supporting cell surface protein function. Alpha Fodrin is one of the important targets cleaved by caspases during apoptosis. The full length 240 kDa protein can be cleaved at several sites within its sequence by activated caspases generating N terminal 150 kDa, C terminal 120 kDa, and 35 kDa major products. Cleavage of alpha Fodrin leads to membrane malfunction and cell shrinkage.Synonyms: Alpha-II spectrin, Fodrin alpha chain, SPTA2, Spectrin non-erythroid alpha chain

Gen-ID: 374234

NCBI Accession: NP_001036003

UniProt: P07751

Pathways: Caspase Kaskade in der Apoptose, Regulation of Actin Filament Polymerization