SCARB1 Antikörper

Produktnummer ABIN1108938

Dieses Anti-SCARB1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von SCARB1 in IHC (fro) und Neut. Geeignet für Ratte.

Kurzübersicht für SCARB1 Antikörper (ABIN1108938)

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SCARB1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro)), Neutralization (Neut)

Klon: 3D12

Produktdetails anti-SCARB1 Antikörper

Kreuzreaktivität (Details): Species reactivity (tested):Rat.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % Sodium Azide, 0.1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C.

Details zu SCARB1

Target: SCARB1 (Scavenger Receptor Class B, Member 1 (SCARB1))

Andere Bezeichnung: SCARB1

Hintergrund: Scavenger receptors have been studied primarily for their ability to bind and internalize modified lipoproteins. They have been found in the development of atherosclerosis and other macrophage-associated functions. Scavenger receptors also function as pattern recognition receptors for a wide variety of pathogens. This finding indicates a potential role in host defense. SR-BI belongs together with CD36 to the class B scavenger receptor family. SR-BI is a multiligand membrane protein existing in various organs such as the liver and various cell types such as endothelial cells, macrophages, brain cells, Leydig cells and Sertoli cells. SR-BI has been found as a receptor for phospholipids, free and (lipo)protein-bound ApoE, lipid-bound ApoA-I, HDL, hypochlorite-modified LDL and more. In liver, the PDZK-1 (and possible other PDZ domains) of SR-BI has been found to be essential for cell surface expression and, hence, reverse cholesterol transport. In the brain, the presence of SR-BI seems to be involved in the uptake of oxidatively modified lipoproteins and beta-amyloid protein complexed with ApoE, suggesting SR-BI to be an important tool for studies on neurodegenerative disorders. In the testis, SR-BI is expressed in two somatic cell types: Leydig cells and Sertoli cells. SR-BI functions at least partly as a phosphatidyl serine receptor (PSR), enabling Sertoli cells to recognize and phagocytose apoptotic spermatogenic cells at all stages of differentiation.Synonyms: CD36 and LIMPII analogous 1, CD36 antigen-like 1, CD36L1, CLA-1, CLA1, Collagen type I receptor thrombospondin receptor-like 1, SR-BI, SRB1, Scavenger receptor class B member 1

Gen-ID: 10116

UniProt: P97943

Pathways: Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Lipid Metabolism, SARS-CoV-2 Protein Interaktom