Retinoblastoma 1 Antikörper (AA 612-928)

Produktnummer ABIN1108868

Der Maus Monoklonal Anti-Retinoblastoma 1-Antikörper wurde für WB, IP und IHC (p) validiert. Er ist geeignet, Retinoblastoma 1 in Proben von Human zu detektieren.

Kurzübersicht für Retinoblastoma 1 Antikörper (AA 612-928) (ABIN1108868)

Target: Retinoblastoma 1 (RB1)

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Retinoblastoma 1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 3H9

Produktdetails anti-Retinoblastoma 1 Antikörper

Bindungsspezifität: AA 612-928

Spezifität: This antibody reacts with retinoblastoma gene product (110-115 kDa).

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein A Sepharose

Immunogen: Recombinant human Rb protein corresponding to amino acids 612-928

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2

Konservierungsmittel: Azide free

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu Retinoblastoma 1

Target: Retinoblastoma 1 (RB1)

Andere Bezeichnung: Retinoblastoma-Associated Protein / RB1

Hintergrund: Mutation of the retinoblastoma tumor suppressor gene alone is sufficient to cause retinoblastoma in humans, suggesting that it might play a role in the normal coordination of cell proliferation and cell death. Deletion or mutational inactivation of the retinoblastoma tumor suppressor protein (Rb) is correlated with the genesis of a variety of human cancers including retinoblastoma, osteosarcoma, and carcinomas of the breast, bladder, and lung. Rb protein is phosphorylated by cyclinD-Cdk4/Cdk6 and cyclinA/cyclinE-Cdk2 during the G1/S transition. This phosphorylation causes the inactivation of the growth inhibitory functions of Rb. Rb undergoes phosphorylation and functional inactivation, permitting the cell to proceed into late G1.Synonyms: OSRC, Rb, Retinoblastoma 1, p105-Rb, pRb, pp110

Gen-ID: 5925

NCBI Accession: NP_000312

UniProt: P06400

Pathways: Zellzyklus, Intracellular Steroid Hormone Receptor Signaling Pathway, Mitotic G1-G1/S Phases, DNA Replication, Maintenance of Protein Location, Synthesis of DNA, Autophagie