MHC Class II Antigen I Ak,d,b,q,r Antikörper

Produktnummer ABIN1108234

Dieses Ratte Monoklonal-Antikörper erkennt spezifisch in FACS und IHC (fro). Er zeigt eine Reaktivität gegenüber Maus und Human.

Kurzübersicht für MHC Class II Antigen I Ak,d,b,q,r Antikörper (ABIN1108234)

Target: MHC Class II Antigen I Ak,d,b,q,r

Reaktivität: Maus, Human

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: ER-TR3

Produktdetails

Kreuzreaktivität (Details): Species reactivity (tested):Mouse, human (tonsil)

Aufreinigung: Protein G

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Prior to reconstitution store at -70 °C. Following reconstitution store the antibody (in aliquots) at < -20 °C for at least 6 months.

Haltbarkeit: 6 months

Antigendetails

Target: MHC Class II Antigen I Ak,d,b,q,r

Andere Bezeichnung: MHC Class II (I-A K,b,d,q,r)

Hintergrund: MHC class II molecules are heterodimers of non-covalently associated alpha (31-34 kDa) and beta (26-29 kDa) chains. Major histocompatibility complex class II antigen presentation requires the participation of lysosomal proteases in two convergent processes. First, the antigens endocytosed by the antigen-presenting cells must be broken down into antigenic peptides. Second, class II molecules are synthesized with their peptide-binding site blocked by invariant chain (Ii), and they acquire the capacity to bind antigens only after Ii has been degraded in the compartments where peptides reside. MHC class II molecules present exogenously derived antigen to CD4+ T lymphocytes, which are usually T helper cells. CD4 interacts with non-polymorphic residues of MHC Class II.