MARCO Antikörper (AA 420-431)

Produktnummer ABIN1108157

Der Maus Monoklonal Anti-MARCO-Antikörper wurde für WB, IP, FACS, IF, IHC (fro) und Func validiert. Er ist geeignet, MARCO in Proben von Human und Rind (Kuh) zu detektieren.

Kurzübersicht für MARCO Antikörper (AA 420-431) (ABIN1108157)

Target: MARCO (Macrophage Receptor with Collagenous Structure (MARCO))

Reaktivität: Human, Rind (Kuh)

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MARCO Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Functional Studies (Func)

Klon: PLK-1

Produktdetails anti-MARCO Antikörper

Bindungsspezifität: AA 420-431

Spezifität: This antibody binds specifically to MARCO (recognizes domain V between residues 420 and 431), and has been shown to partially block ligand binding.

Keine Kreuzreaktivität: Huhn

Kreuzreaktivität (Details): Species reactivity (tested):Human, Bovine.

Aufreinigung: Protein G Chromatography

Immunogen: Human alveolar macrophages

Isotyp: IgG3

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % BSA

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C.

Details zu MARCO

Target: MARCO (Macrophage Receptor with Collagenous Structure (MARCO))

Andere Bezeichnung: MARCO

Hintergrund: The scavenger receptors (SRs) expressed by macrophages are thought to play an important role in the immune response against bacteria by mediating ligand binding and phagocytosis. SRs can be divided into three different classes based upon their structural properties, which are termed SR-A, SR-B and SR-C. SRs-A are homotrimeric glycoproteins composed of 77 kDa monomers subdivided into 3 types.. The molecular structure of MARCO resembles that of SR-A type I, containing a triple-helical collagenous domain and a scavenger receptor cysteine-rich (SRCR) domain at the C terminus. MARCO is only expressed in some subpopulations of macrophages, although it's expression can be strongly upregulated during infection or LPS treatment. Furthermore, MARCO is, like sinusoidal endothelial cell markers DC-SIGNR, LYVE-1 and stabilin-2, expressed by sinusoidal endothelial cells in lymph node. MARCO expressed by alveolar macrophages seems to play an important role in response to inhaled particles and airborne pathogens.Synonyms: Scavenger Receptor, macrophage receptor with collagenous structure

Gen-ID: 8685

NCBI Accession: NP_006761

UniProt: Q9UEW3

Pathways: Activation of Innate immune Response