MAPT Antikörper (pThr181)

Produktnummer ABIN1108152

Dieses Anti-MAPT-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von MAPT in WB. Geeignet für Human und Maus.

Kurzübersicht für MAPT Antikörper (pThr181) (ABIN1108152)

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MAPT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Klon: 1A4

Produktdetails anti-MAPT Antikörper

Bindungsspezifität: AA 177-187, pThr181

Sequenz: Ala-Pro-Lys-Thr(p)-Pro-Pro-Ser-Ser-Gly-Glu-Cys

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Protein G affinity purified

Immunogen: KLH conjugated with a short peptide corresponding to the amino acid sequence 177-187 on the phosphorylated Tau protein

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Rekonstitution: Double distillated water is recommended to reconstitute the antibody.

Buffer: 0.01 M PBS pH 7.2

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20 °C.

Details zu MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Andere Bezeichnung: MAPT / tau

Hintergrund: Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau

Gen-ID: 9606

UniProt: P10636

Pathways: MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size