Cyclin D1 Antikörper

Produktnummer ABIN1106871

Dieses Anti-Cyclin D1-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von Cyclin D1 in WB, FACS, IP und IHC (p). Geeignet für Human und Maus.

Kurzübersicht für Cyclin D1 Antikörper (ABIN1106871)

Target: Cyclin D1 (CCND1)

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cyclin D1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: 5D4

Produktdetails anti-Cyclin D1 Antikörper

Spezifität: This antibody reacts with human Cyclin D1 (36 kDa). This clone 5D4 recognizes human Cyclin D1, D2 and mouse Cyclin D1, D2, but not human and mouse Cyclin D3.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Protein A agarose

Immunogen: Recombinant human PRAD1/Cyclin D1

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS containing 50 % glycerol, pH 7.2

Konservierungsmittel: Azide free

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store (in aliquots) at -20 °C.

Details zu Cyclin D1

Target: Cyclin D1 (CCND1)

Andere Bezeichnung: Cyclin D1

Hintergrund: Cyclin D1, also known as Bcl-1, CCND1, or PRAD-1, is a 36 kDa nuclear protein that plays a key regulatory role during the G1 phase of the cell cycle by regulating the activity of Cdk proteins. Cyclin D1 forms a complex with Cdk4, then binds to and phosphorylates Rb protein, triggering cells to progress from G0/G1 to S and thus driving cellular proliferation. Cyclin D1 protein overexpression is found in the majority of human breast cancers and is usually linked with poor prognosis. Overexpression of cyclin D1 is a well-established criterion for the diagnosis of Mantle Cell Lymphoma, and also has been used to distinguish malignant breast carcinomas from premalignant breast lesions.Synonyms: BCL-1 oncogene, BCL1, CCND1, Cyclin-D1, G1/S-specific cyclin-D1, PRAD-1 oncogene, PRAD1

Gen-ID: 595

NCBI Accession: NP_444284

UniProt: P24385

Pathways: PI3K-Akt Signalweg, Zellzyklus, Mitotic G1-G1/S Phases, ER-Nucleus Signaling