C3 Antikörper

Produktnummer ABIN1106776

Produktdetails anti-C3 Antikörper

Target: C3 (Complement Component 3 (C3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser C3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität (Details): Species reactivity (tested):Human.

Aufreinigung: Protein G Chromatography

Klon: BH6

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.02 % Sodium Azide, 0.1 % BSA

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C.

Details zu C3

Target: C3 (Complement Component 3 (C3))

Andere Bezeichnung: Complement C3 (C3 Produkte)

Synonyme: AHUS5 antikoerper, ARMD9 antikoerper, ASP antikoerper, C3a antikoerper, C3b antikoerper, CPAMD1 antikoerper, AI255234 antikoerper, HSE-MSF antikoerper, Plp antikoerper, C3 antikoerper, C3-1 antikoerper, sb:cb26 antikoerper, si:dkey-76b14.4 antikoerper, wu:fi34b03 antikoerper, wu:fj86e11 antikoerper, C3d antikoerper, asp antikoerper, cpamd1 antikoerper, c3 antikoerper, complement C3 antikoerper, complement component 3 antikoerper, complement component c3a, duplicate 1 antikoerper, complement component 3 L homeolog antikoerper, complement component C3 antikoerper, complement C3-like antikoerper, C3 antikoerper, c3a.1 antikoerper, c3.L antikoerper, LOC443475 antikoerper, c3 antikoerper, c3-1 antikoerper, LOC100060539 antikoerper

Hintergrund: The complement system is an important factor in innate immunity. The third complement component, C3, is central to the classical, alternative and lectin pathways of complement activation. Activation products of the complement cascade contain neo-epitopes that are not present in the individual native components. Monoclonal antibodies detecting neo-epitopes have been used for direct quantification of activation at different steps in the complement cascade. The synthesis of C3 is tissue-specific and is modulated in response to a variety of stimulatory agents. C3 is the most abundant protein of the complement system with serum protein levels of about 1.3 mg/mL. An inherited deficiency of C3 predisposes the person to frequent assaults of bacterial infections. In ulcerative colitis, and idiopathic chronic inflammatory bowel disease, the deposition of C3 in the diseased mucosa has been reported. Proteolysis by certain enzymes results in the cleavage of C3 into C3a and C3b. C3b becomes attached to immune complexes and is further cleaved into iC3b, C3c, C3dg and C3f.Synonyms: C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1, CPAMD1, Complement component 3

UniProt: P01024

Pathways: Komplementsystem, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Regulation of G-Protein Coupled Receptor Protein Signaling