CD46 Antikörper

Produktnummer ABIN1106417

Der Maus Monoklonal Anti-CD46-Antikörper wurde für WB, IP, Func und EIA validiert. Er ist geeignet, CD46 in Proben von Human zu detektieren.

Kurzübersicht für CD46 Antikörper (ABIN1106417)

Target: CD46

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CD46 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunoprecipitation (IP), Functional Studies (Func), Enzyme Immunoassay (EIA)

Klon: M177

Produktdetails anti-CD46 Antikörper

Spezifität: The monoclonal antibody M177 recognizes CD46, also designated membrane cofactor protein (MCP).

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Protein G

Immunogen: Purified MCP

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.1 % bovine serum albumin

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2 - 8 °C.

Details zu CD46

Target: CD46

Andere Bezeichnung: CD46 / MCP

Hintergrund: CD46 is a 45-70 kDa protein with genetic and tissue-specific heterogeneity. It is expressed on every cell and tissue, with the exception of erythrocytes. CD46 serves to inhibit complement activation on host tissue. It performs this function by serving as a cofactor which binds to C3b and C4b. This binding is permitted by factor I, a serine protease of plasma, to degrade C3b and C4b and serves to protect the host cell against autologous attack. It also serves as a receptor for measles virus. Four isoforms of CD46 predominate and arise by alternative splicing of a single CD46 gene. CD46 cDNA encodes a signal sequence followed by four complement control protein domains (also called short consensus repeats (SCR).Synonyms: MIC10, Membrane cofactor protein, TLX, Trophoblast leukocyte common antigen

Gen-ID: 4179

NCBI Accession: NP_002380

UniProt: P15529

Pathways: Regulation of Actin Filament Polymerization