PLAP Antikörper

Produktnummer ABIN1105297

Dieses Maus Monoklonal-Antikörper erkennt spezifisch PLAP in IHC (fro) und EIA. Er zeigt eine Reaktivität gegenüber Tag.

Kurzübersicht für PLAP Antikörper (ABIN1105297)

Target: PLAP (ALPP) (Placental Alkaline Phosphatase (ALPP))

Reaktivität: Tag

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser PLAP Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)

Klon: V17-1

Produktdetails anti-PLAP Antikörper

Spezifität: This antibody clone V17.1 reacts with alkaline phosphatase, an enzym widely used in immunodection tests. Can be used for detection of Alkaline Phophatase and for amplification of Alkaline Phophatase reactions (APAP).

Aufreinigung: Purified

Immunogen: A BALB/c Mouse was immunized with Alkaline Phophatase.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 0.1 mg/mL

Buffer: PBS, 0.05 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or -20 °C for longer.

Details zu PLAP

Target: PLAP (ALPP) (Placental Alkaline Phosphatase (ALPP))

Substanzklasse: Tag

Hintergrund: There are at least four distinct but related alkaline phosphatases: intestinal, placental, placental-like, and liver/bone/kidney (tissue non-specific). The first three are located together on chromosome 2, while the tissue non-specific form is located on chromosome 1. The product of this gene is a membrane bound glycosylated enzyme that is not expressed in any particular tissue and is, therefore, referred to as the tissue-nonspecific form of the enzyme. The exact physiological function of the alkaline phosphatases is not known. A proposed function of this form of the enzyme is matrix mineralization, however, mice that lack a functional form of this enzyme show normal skeletal development. This enzyme has been linked directly to hypophosphatasia, a disorder that is characterized by hypercalcemia and includes skeletal defects. The character of this disorder can vary, however, depending on the specific mutation since this determines age of onset and severity of symptoms. Alternatively spliced transcript variants, which encode the same protein, have been identified for this gene.Synonyms: Alkaline phosphatase, Alkaline phosphatase Regan isozyme, PLAP-1, placental type

Gen-ID: 250

NCBI Accession: NP_001623

UniProt: P05187