STAT5A Antikörper (AA 583-794)

Produktnummer ABIN1098129

Dieses Anti-STAT5A-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von STAT5A in WB, IHC, ELISA, FACS und ICC. Geeignet für Human. Dieses Primary Antibody wurde in 2+ Publikationen zitiert.

Kurzübersicht für STAT5A Antikörper (AA 583-794) (ABIN1098129)

Target: STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser STAT5A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Flow Cytometry (FACS), Immunocytochemistry (ICC)

Klon: 6D4

Produktdetails anti-STAT5A Antikörper

Bindungsspezifität: AA 583-794

Verwendungszweck: STAT5A Antibody

Aufreinigung: Purified antibody

Immunogen: Purified recombinant fragment of human STAT5A (AA: 583-794 ) expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

ELISA: 1/10000

FCM: 1/200 - 1/400

ICC: 1/50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified antibody in PBS with 0.05 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.

Referenzen für anti-STAT5A Antikörper (ABIN1098129)

Cerliani, Guillardoy, Giulianelli, Vaque, Gutkind, Vanzulli, Martins, Zeitlin, Lamb, Lanari: "Interaction between FGFR-2, STAT5, and progesterone receptors in breast cancer." in: Cancer research, Vol. 71, Issue 10, pp. 3720-31, (2011) (PubMed).

Warsch, Kollmann, Eckelhart, Fajmann, Cerny-Reiterer, Hölbl, Gleixner, Dworzak, Mayerhofer, Hoermann, Herrmann, Sillaber, Egger, Valent, Moriggl, Sexl: "High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia." in: Blood, Vol. 117, Issue 12, pp. 3409-20, (2011) (PubMed).

Details zu STAT5A

Target: STAT5A (Signal Transducer and Activator of Transcription 5A (STAT5A))

Andere Bezeichnung: STAT5A

Hintergrund: The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein is activated by, and mediates the responses of many cell ligands, such as IL2, IL3, IL7 GM-CSF, erythropoietin, thrombopoietin, and different growth hormones. Activation of this protein in myeloma and lymphoma associated with a TEL/JAK2 gene fusion is independent of cell stimulus and has been shown to be essential for the tumorigenesis. The mouse counterpart of this gene is found to induce the expression of BCL2L1/BCL-X(L), which suggests the antiapoptotic function of this gene in cells.

Molekulargewicht: 90.6 kDa

Gen-ID: 6776

UniProt: P42229

Pathways: JAK-STAT Signalweg, RTK Signalweg, Response to Growth Hormone Stimulus, C21-Steroid Hormone Metabolic Process, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, CXCR4-mediated Signaling Events, Activated T Cell Proliferation