GZMB Antikörper
Kurzübersicht für GZMB Antikörper (ABIN108719)
Target
Alle GZMB Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
Klon
-
-
Spezifität
- GM4C1 recognises granzyme B transiently expressed on the cell surface of transfected BOSC cells as well as the native protein in peripheral blood mononuclear cells. The antibody does not cross-react with the human granzymes A, K or M (Fi
-
Aufreinigung
- Protein G
-
Immunogen
- genetic immunisation with cDNA encoding human Granzyme B
-
Isotyp
- IgG1
-
-
-
-
Applikationshinweise
-
Flow cytometry: 1.2 µg/10^6 cells
ELISA: 1:200 - 1:400
CELISA: 1:200 - 1:400
For each application a titration should be performed to determine the optimal concentration. -
Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
-
-
Buffer
- PBS, pH 7.2
-
Handhabung
- Avoid repeated freezing and thawing.
-
Lagerung
- 4 °C
-
Informationen zur Lagerung
- short term: 2 °C - 8 °C, long term: -20 °C
-
-
- GZMB (Granzyme B (GZMB))
-
Andere Bezeichnung
- Granzyme B
-
Hintergrund
- Granzymes are exogenous serine proteases that are stored in the cytotoxic granules of activated T cells and NK cells. GM4C1 was generated by genetic immunisation and reacts with human granzyme B (GrB), a 27 kDa serine protease which cleaves target-cell proteins at specific aspartate residues.
-
UniProt
- P10144
-
Pathways
- Apoptose, Caspase Kaskade in der Apoptose
Target
-