SARS-CoV Spike Antikörper (Intermediate Domain 1)

Produktnummer ABIN1031189

Der Kaninchen Polyklonal Anti-SARS-CoV Spike-Antikörper wurde für ELISA validiert. Er ist geeignet, SARS-CoV Spike in Proben von SARS Coronavirus (SARS-CoV) zu detektieren.

Kurzübersicht für SARS-CoV Spike Antikörper (Intermediate Domain 1) (ABIN1031189)

Target: SARS-CoV Spike (SARS-CoV S) (SARS-Coronavirus Spike Protein (SARS-CoV S))

Reaktivität: SARS Coronavirus (SARS-CoV)

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser SARS-CoV Spike Antikörper ist unkonjugiert

Applikation: ELISA

Produktdetails anti-SARS-CoV Spike Antikörper

Bindungsspezifität: Intermediate Domain 1

Homologie: Predicted reactivity based on immunogen sequence: SARS-CoV2 Spike protein: (identity 56%, homology 69%)

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: Anti-SARS-CoV Spike antibody was raised against a peptide corresponding to 16 amino acids near the center of SARS-CoV Spike glycoprotein.
The immunogen is located within amino acids 410-460 of SARS-CoV Spike.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: SARS-CoV Spike antibody can be used for the detection of SARS-CoV Spike protein in ELISA. It will detect 2 ng of free peptide at 1 μg/mL.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: The antibody is supplied in PBS containing 0.02% sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: The antibody can be stored at 4 ˚ C for three months and -20 ˚ C, stable for up to one year.

Haltbarkeit: 12 months

Details zu SARS-CoV Spike

Target: SARS-CoV Spike (SARS-CoV S) (SARS-Coronavirus Spike Protein (SARS-CoV S))

Andere Bezeichnung: SARS-CoV Spike

Substanzklasse: Viral Protein

Hintergrund: Coronavirus disease 2019 (COVID-19), formerly known as 2019-nCoV acute respiratory disease, is an infectious disease caused by SARS-CoV-2, a virus closely related to the SARS virus. The disease is the cause of the 2019–20 coronavirus outbreak. The structure of 2019-nCoV consists of the following: a Spike protein (S), hemagglutinin-esterease dimer (HE), a membrane glycoprotein (M), an envelope protein (E) a nucleoclapid protein (N) and RNA. Coronavirus invades cells through Spike (S) glycoproteins, a class I fusion protein. It is the major viral surface protein that coronavirus uses to bind to the human cell surface receptor. It also mediates the fusion of host and viral cell membrane, allowing the virus to enter human cells and begin infection. The spike protein is the major target for neutralizing antibodies and vaccine development. The protein modeling suggests that there is strong interaction between Spike protein receptor-binding domain and its host receptor angiotensin-converting enzyme 2 (ACE2), which regulate both the cross-species and human-to-human transmissions of COVID-19. The recent study has shown that the SARS-CoV-2 spike protein binds ACE2 with higher affinity than SARS-CoV spike protein .

Gen-ID: 1489668

NCBI Accession: P59594