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SARS-CoV Spike Antikörper (AA 532-562)

SARS-CoV S Reaktivität: SARS Coronavirus (SARS-CoV) WB Wirt: Kaninchen Polyclonal RB3983-3984 unconjugated
Produktnummer ABIN1882128
  • Target Alle SARS-CoV Spike (SARS-CoV S) Antikörper anzeigen
    SARS-CoV Spike (SARS-CoV S) (SARS-Coronavirus Spike Protein (SARS-CoV S))
    Bindungsspezifität
    • 15
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 532-562
    Reaktivität
    • 43
    • 16
    SARS Coronavirus (SARS-CoV)
    Wirt
    • 40
    • 3
    Kaninchen
    Klonalität
    • 40
    • 3
    Polyklonal
    Konjugat
    • 27
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SARS-CoV Spike Antikörper ist unkonjugiert
    Applikation
    • 34
    • 26
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Aufreinigung
    This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS. Purified Rabbit Polyclonal Antibody (Pab)
    Immunogen
    This SARS virus Sm antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 532-562 amino acids from the middle of SARS CoV Spike protein.
    Klon
    RB3983-3984
    Top Product
    Discover our top product SARS-CoV S Primärantikörper
  • Applikationshinweise
    WB: 1:1000
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    2 mg/mL
    Buffer
    Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
  • Lee, Poo, Han, Hong, Kim, Cho, Kim, Sung, Kim: "Mucosal immunization with surface-displayed severe acute respiratory syndrome coronavirus spike protein on Lactobacillus casei induces neutralizing antibodies in mice." in: Journal of virology, Vol. 80, Issue 8, pp. 4079-87, (2006) (PubMed).

    Ito, Mossel, Narayanan, Popov, Huang, Inoue, Peters, Makino: "Severe acute respiratory syndrome coronavirus 3a protein is a viral structural protein." in: Journal of virology, Vol. 79, Issue 5, pp. 3182-6, (2005) (PubMed).

    Chan, Wu, Chow, Cheung, To, Leung, Chan, Lee, Ng, Au, Lo: "Coronaviral hypothetical and structural proteins were found in the intestinal surface enterocytes and pneumocytes of severe acute respiratory syndrome (SARS)." in: Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc, Vol. 18, Issue 11, pp. 1432-9, (2005) (PubMed).

    Pogrebnyak, Golovkin, Andrianov, Spitsin, Smirnov, Egolf, Koprowski: "Severe acute respiratory syndrome (SARS) S protein production in plants: development of recombinant vaccine." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 102, Issue 25, pp. 9062-7, (2005) (PubMed).

    He, Dobie, Ballantine, Leeson, Li, Bastien, Cutts, Andonov, Cao, Booth, Plummer, Tyler, Baker, Li: "Analysis of multimerization of the SARS coronavirus nucleocapsid protein." in: Biochemical and biophysical research communications, Vol. 316, Issue 2, pp. 476-83, (2004) (PubMed).

    Hogan, Gao, Rowe, Bell, Flieder, Paragas, Kobinger, Wivel, Crystal, Boyer, Feldmann, Voss, Wilson: "Resolution of primary severe acute respiratory syndrome-associated coronavirus infection requires Stat1." in: Journal of virology, Vol. 78, Issue 20, pp. 11416-21, (2004) (PubMed).

    Song, Seo, Stadler, Yoo, Choo, Coates, Uematsu, Harada, Greer, Polo, Pileri, Eickmann, Rappuoli, Abrignani, Houghton, Han: "Synthesis and characterization of a native, oligomeric form of recombinant severe acute respiratory syndrome coronavirus spike glycoprotein." in: Journal of virology, Vol. 78, Issue 19, pp. 10328-35, (2004) (PubMed).

    Snijder, Bredenbeek, Dobbe, Thiel, Ziebuhr, Poon, Guan, Rozanov, Spaan, Gorbalenya: "Unique and conserved features of genome and proteome of SARS-coronavirus, an early split-off from the coronavirus group 2 lineage." in: Journal of molecular biology, Vol. 331, Issue 5, pp. 991-1004, (2003) (PubMed).

  • Target
    SARS-CoV Spike (SARS-CoV S) (SARS-Coronavirus Spike Protein (SARS-CoV S))
    Abstract
    SARS-CoV S Produkte
    Substanzklasse
    Viral Protein
    Hintergrund
    An outbreak of atypical pneumonia, referred to as severe acute respiratory syndrome (SARS) and first identified in Guangdong Province, China, has spread to several countries. The severity of this disease is such that the mortality rate appears to be approx. 3 to 6%. A number of laboratories worldwidehave undertaken the identification of the causative agent. The National Microbiology Laboratory in Canada obtained the Tor2 isolate from a patient in Toronto, and succeeded in growing a coronavirus-like agent in African Green Monkey Kidney (Vero E6) cells. This coronavirus has been named publicly by the World Health Organization and member laboratories as SARS virus. The SARS membrane proteins, including the major proteins S (Spike) and M (Membrane), are inserted into the endoplasmic reticulum Golgi intermediate compartment (ERGIC) while full length replicated RNA (+ strands) assemble with the N (nucleocapsid) protein. The virus then migrates through the Golgi complex and eventually exits the cell, likely by exocytosis. The site of viral attachment to the host cell resides within the S protein. Oligomeric spike (S) glycoproteins extend from SARS membranes. These integral membrane proteins assemble within the endoplasmic reticulum of infected cells and are subsequently endoproteolyzed in the Golgi, generating noncovalently associated S1 and S2 fragments. Once on the surface of infected cells and virions, peripheral S1 fragments bind carcinoembryonic antigen-related cell adhesion molecule (CEACAM) receptors, and this triggers membrane fusion reactions mediated by integral membrane S2 fragments.

    Synonyms: S, Spike glycoprotein, E2, Peplomer protein, Spike protein S1, Spike protein S2
    UniProt
    P59594
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