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Human Polyclonal PYCARD Primary Antibody für ICC, IF - ABIN4281803
Yao, Carlson, Sun, Ma, Wolf, Minei, Zang: Mitochondrial ROS Induces Cardiac Inflammation via a Pathway through mtDNA Damage in a Pneumonia-Related Sepsis Model. in PLoS ONE 2015
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Human Polyclonal PYCARD Primary Antibody für WB - ABIN610691
Auphan, DiDonato, Rosette, Helmberg, Karin: Immunosuppression by glucocorticoids: inhibition of NF-kappa B activity through induction of I kappa B synthesis. in Science (New York, N.Y.) 1995
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Human Polyclonal PYCARD Primary Antibody für IHC (p), IHC - ABIN257733
Ohtsuka, Ryu, Minamishima, Macip, Sagara, Nakayama, Aaronson, Lee: ASC is a Bax adaptor and regulates the p53-Bax mitochondrial apoptosis pathway. in Nature cell biology 2004
Human Monoclonal PYCARD Primary Antibody für FACS, IHC - ABIN4281806
Peng, French, Tillman, Morgan, French: The inflammasome in alcoholic hepatitis: Its relationship with Mallory-Denk body formation. in Experimental and molecular pathology 2014
Human Polyclonal PYCARD Primary Antibody für WB - ABIN4281797
Siraj, Hussain, Al-Rasheed, Ahmed, Bavi, Alsobhi, Al-Nuaim, Uddin, Al-Kuraya: Demethylation of TMS1 gene sensitizes thyroid cancer cells to TRAIL-induced apoptosis. in The Journal of clinical endocrinology and metabolism 2011
Human Polyclonal PYCARD Primary Antibody für IHC, IHC (fro) - ABIN4281795
Doitsh, Galloway, Geng, Yang, Monroe, Zepeda, Hunt, Hatano, Sowinski, Muñoz-Arias, Greene: Cell death by pyroptosis drives CD4 T-cell depletion in HIV-1 infection. in Nature 2014
Human PYCARD Primary Antibody für ELISA, WB - ABIN645848
Ansari, Dutta, Veettil, Dutta, Iqbal, Kumar, Roy, Chikoti, Singh, Chandran: Herpesvirus Genome Recognition Induced Acetylation of Nuclear IFI16 Is Essential for Its Cytoplasmic Translocation, Inflammasome and IFN-β Responses. in PLoS pathogens 2015
Data show that in HK-2 (zeige HK2 Antikörper) cells and unilateral nephrectomy model, ASC expression level is significantly augmented after treatment with contrast media. Its silencing attenuates contrast-induced apoptosis in HK-2 (zeige HK2 Antikörper) cell.
ASC specks released by microglia bind to amyloid-beta and increase amyloid-beta oligomer and aggregate formation, acting as an inflammation-driven cross-seed for amyloid-beta pathology
ASC contributes to oral cavity squamous cell carcinoma metastasis, and high-level ASC expression is a marker for poor prognosis in OSCC patients
ASC CpG methylation may prove to be a primary regulator of the pathogenesis of chronic inflammatory diseases such as heart failure.
besides its role in the inhibition of the NF-kappaB (zeige NFKB1 Antikörper) pathway, NLRC3 (zeige NLRC3 Antikörper) interferes with the assembly and activity of the NALP3 inflammasome complex by competing with ASC for pro-caspase-1 (zeige CASP1 Antikörper) binding
ASC Induces Apoptosis via Activation of Caspase-9 by Enhancing Gap Junction-Mediated Intercellular Communication.(
These data revealed that cross-linking of ASC(PYD) filaments via ASC(CARD) mediates the assembly of ASC foci.
Down-regulation of mRNA expression was found in cases in which CASP8 (zeige CASP8 Antikörper), TMS1 (zeige SERINC3 Antikörper) and DAPK (zeige DAPK1 Antikörper) were hypermethylated.
loss of ASC driven tumor development is counterbalanced in the identical cell by the inhibition of pro-tumorigenic inflammation in the tumor cell itself
the deubiquitinating enzyme USP50 (zeige USP50 Antikörper) binds to the ASC protein and subsequently regulates the inflammasome signaling pathway.
ASC (zeige STS Antikörper) specks released by microglia bind to amyloid-beta and increase amyloid-beta oligomer and aggregate formation, acting as an inflammation-driven cross-seed for amyloid-beta pathology
results suggest that although Pyk2 and FAK are involved in inflammasome activation, only Pyk2 directly phosphorylates ASC and brings ASC into an oligomerization-competent state by allowing Tyr146 phosphorylation to participate ASC speck formation and subsequent NLRP3 inflammation.
Alendronate (ALN (zeige TTC21B Antikörper))-augmented IL-1beta (zeige IL1B Antikörper) production and cell death require Smad3 (zeige SMAD3 Antikörper) and ASC (zeige STS Antikörper) activation, and SIS3 and anti-ASC (zeige STS Antikörper) antibodies may serve as palliative agents for necrotizing inflammatory diseases caused by ALN (zeige TTC21B Antikörper)
These data provide evidence that the inflammasome components ASC (zeige STS Antikörper), NLRP3 and AIM2 (zeige AIM2 Antikörper) play a role in regulating macrophage adhesion and activation in response to surface nanotopography and chemistry.
SGLT-2 (zeige SLC5A2 Antikörper) inhibition with dapagliflozin reduces the activation of the Nlrp3/ASC (zeige STS Antikörper) inflammasome and attenuates the development of diabetic cardiomyopathy in mice with type 2 diabetes. Effects are augmentated of the by DPP4 (zeige DPP4 Antikörper) inhibitor Saxagliptin.
Elevations of CO2 cause oligomerization of the inflammasome components ASC (zeige STS Antikörper), NLRP3, caspase 1 (zeige CASP1 Antikörper), thioredoxin interacting protein (zeige TXNIP Antikörper), and calreticulin (zeige CALR Antikörper) - a protein from endoplasmic reticulum, leading to IL-1beta (zeige IL1B Antikörper) synthesis. An increased production rate of MPs containing elevated amounts of IL-1beta (zeige IL1B Antikörper) persists for hours after short-term exposures to elevated CO2
Our cumulative findings indicate that ASC (zeige STS Antikörper) suppresses cancer metastasis and progression via the modulation of cytoskeletal remodeling and the Src (zeige SRC Antikörper)-caspase-8 (zeige CASP8 Antikörper) signaling pathway.
these findings suggest that p205 (zeige GNB2L1 Antikörper) controls expression of Asc (zeige STS Antikörper) mRNA to regulate inflammasome responses. These findings expand on our understanding of immune-regulatory roles for the PYHIN protein family.
this study shows that ASC (zeige STS Antikörper)-dependent Inflammasomes do not shape the commensal gut (zeige GUSB Antikörper) microbiota composition
Our data identify RIPK3 (zeige RIPK3 Antikörper) and the ASC (zeige STS Antikörper) inflammasome as key tumor suppressors in AML (zeige RUNX1 Antikörper).
This gene encodes an adaptor protein that is composed of two protein-protein interaction domains: a N-terminal PYRIN-PAAD-DAPIN domain (PYD) and a C-terminal caspase-recruitment domain (CARD). The PYD and CARD domains are members of the six-helix bundle death domain-fold superfamily that mediates assembly of large signaling complexes in the inflammatory and apoptotic signaling pathways via the activation of caspase. In normal cells, this protein is localized to the cytoplasm\; however, in cells undergoing apoptosis, it forms ball-like aggregates near the nuclear periphery. Two transcript variants encoding different isoforms have been found for this gene.
apoptosis-associated speck-like protein containing a CARD
, caspase recruitment domain-containing protein 5
, target of methylation-induced silencing 1
, PYD and CARD domain-containing protein