anti-serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9) Antikörper

Pig (Porcine) serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9) Interaktionspartner

Mouse (Murine) serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9) Interaktionspartner

1. Data suggest that reactive oxygen species (ROS) generated within cytotoxic lymphocytes by receptor stimulation are required for lysosomal permeabilization and release of GzmB (granzyme B) into the cytosol and for inactivation of serpin B9.

2. the negative regulation of DC priming of CD8 (zeige CD8A Antikörper) T lymphocyte immunity by CTL killing is mitigated by the physiological inhibition of GrB by Spi6.

3. SPI-CI (zeige OVA Antikörper) is a novel immune escape molecule that acts in concert with SPI (zeige CHGA Antikörper)-6 to prevent cytotoxic lymphocyte-mediated killing of tumor cells.

4. Estrogen induction of PI-9 may reduce the ability of cytolytic lymphocytes-mediated immune surveillance to destroy newly transformed cells

5. In mCAP3 (zeige ST14 Antikörper), an intact catalytic triad was necessary for activation of ENaC (zeige SCNN1A Antikörper) but not for intramolecular cleavage of the protease.

6. protects hepatocytes against excessively vigorous granzyme B-dependent killing but may also delay immune clearance of virally infected hepatocytes

7. deficiency in a weak intracellular inhibitor of neutrophil elastase (zeige ELANE Antikörper) results in an acute inflammatory response that protects from P. aeruginosa but does not cause lung disease

8. SPI-6 is selectively up-regulated in hepatocytes in response to infiltration of the liver by NK cells that express perforin and enzymatically active granzyme B.

9. Increased SPI (zeige CHGA Antikörper)-6 expression is not sufficient to confer lipopolysaccharide-treated dendritic cells with resistance to direct killing in vivo.

Human serpin Peptidase Inhibitor, Clade B (Ovalbumin), Member 9 (SERPINB9) Interaktionspartner

1. Data show that the serine protease inhibitor B9 (serpinB9) mediated caspase-1 (zeige CASP1 Antikörper) inhibition regulates IL-1beta (zeige IL1B Antikörper) release in monocytes.

2. Treatment with estrogens further increased PI-9 level while decreased that of ERalpha66 isoform thus excluding the involvement of this receptor isoform in the event. Moreover, our studies also provided evidence that tertiary tumorspheres express elevated levels of CXCR4 (zeige CXCR4 Antikörper) and phospho-p38 (zeige CRK Antikörper), suggesting that the high PI-9 content might be ascribed to the activation of the proliferative CXCR4 (zeige CXCR4 Antikörper)/phospho-p38 (zeige CRK Antikörper) axis.

3. We filtered four OSCC genes including SERPINB9, SERPINE2 (zeige SERPINE2 Antikörper), GAK (zeige GAK Antikörper), and HSP90B1 (zeige HSP90B1 Antikörper) through the gene global prioritization score (P < 0.005).

4. Data show that oropharyngeal squamous cell carcinomas (OPSCCs) express granzyme inhibitors SERPINB1 (zeige SERPINB1 Antikörper), SERPINB4 (zeige SERPINB4 Antikörper) and SERPINB9 for cytotoxicity and the expression was not different between human papillomavirus (HPV)-positive and HPV-negative tumors.

5. Pediatric CNS-PNETs evade immune recognition by downregulating cell surface MHC (zeige HLAE Antikörper)-I and CD1d (zeige CD1D Antikörper) expression. Intriguingly, expression of SERPINB9, SERPINB1 (zeige SERPINB1 Antikörper), and SERPINB4 (zeige SERPINB4 Antikörper) is acquired during tumorigenesis in 29%, 29%, and 57% of the tumors

6. Data suggest that reactive oxygen species (ROS) generated within cytotoxic lymphocytes by receptor stimulation are required for lysosomal permeabilization and release of GzmB (granzyme B) into the cytosol and for inactivation of serpin B9.

7. Increased intracellular PI-9 activity in mononuclear phagocytes from HIV-infected patients contributes to successful intracellular infection by virulent Mycobacterium tuberculosis.

8. Suppression of granzyme B initiated apoptosis in protease inhibitor-9-expressing leukemia cells.

9. SerpinB9 expression in human renal tubular epithelial cells is induced by triggering of the viral dsRNA sensors TLR3 (zeige TLR3 Antikörper), MDA5 (zeige IFIH1 Antikörper) and RIG-I (zeige DDX58 Antikörper) during subclinical rejection.

10. lung cancer cells utilise their increased PI-9 expression to protect from granzyme B-mediated cytotoxicity as an immune evasion mechanism