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VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases.
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Human Polyclonal VRK1 Primary Antibody für ICC, IF - ABIN4365869
Sanz-García, Monsalve, Sevilla, Lazo: Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage. in The Journal of biological chemistry 2012
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Human Monoclonal VRK1 Primary Antibody für WB - ABIN1882291
Barcia, López-Borges, Vega, Lazo: Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1. in Archives of biochemistry and biophysics 2002
Show all 5 Pubmed References
vrk-1 has a role in early uterine development in Caenorhabditis elegans
By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans.
Genome-wide analysis of germ cell proliferation in C. elegans identifies vrk-1 as a key regulator of cep-1/p53 (zeige TP53 Antikörper).
Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.
this study not only provides a resource for investigating the unidentified functions of VRK1/VRK3, but also an insight into the regulatory roles of VRK1/VRK3 in biological processes.
Block the activation of the VRK1 promoter by Sox2 (zeige SOX2 Antikörper).
VRK1 and BANF1 (zeige BANF1 Antikörper) yielded AUCs of 0.790 and 0.735, respectively.
VRK1 AND VRK2 (zeige VRK2 Antikörper) expression are predictive of tumor response to neoadjuvant chemoradiation therapy in rectal adenocarcinoma.
VRK1 was lowly expressed in adherent MM cells and highly expressed in suspended cells. In addition, VRK1 was positively correlated with the proliferation of MM cells by regulating the expression of cell cycle-related protein, such as cyclinD1, CDK2 (zeige CDK2 Antikörper) and p27(kip1 (zeige CDKN1B Antikörper)).
we conclude that VRK1 may be a candidate prognostic biomarker as well as a potential therapeutical target of hepatocellular carcinoma
VRK1 may act as a tumor promoter by controlling the level of cell cycle regulators associated with G1/S transition and could potentially serve as a therapeutic target and/or prognostic biomarker for HCC (zeige FAM126A Antikörper).
VRK1 is a novel regulator of CBs (zeige CBS Antikörper) dynamics and stability in cell cycle by protecting coilin (zeige COIL Antikörper) from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.
VRK1 regulation of NBS1 (zeige NBN Antikörper) contributes to the stability of the repair complex and permits the sequential steps in DNA damage response.
VRK1 is a novel chromatin component that reacts to its alterations and participates very early in DNA damage response, functioning by itself or in cooperation with Ataxia Telangiectasia Mutated (zeige ATM Antikörper) Proteins.
VRK1 self-represses its activity to phosphorylate PXR (zeige NR1I2 Antikörper) through cyclin-dependent kinase 2 (CDK2 (zeige CDK2 Antikörper)) in high glucose conditions, resulting in the repression of the PCK1 (zeige PCK1 Antikörper) gene. This PXR (zeige NR1I2 Antikörper) phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2 (zeige CDK2 Antikörper)-PXR (zeige NR1I2 Antikörper)-PP2Calpha (zeige PPM1A Antikörper)-SGK2 (zeige SGK2 Antikörper) pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.
VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (zeige APP Antikörper)). APP (zeige APP Antikörper) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (zeige APP Antikörper)-dependent mechanism.
Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.
Protein kinase (zeige CDK7 Antikörper) Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53 (zeige TP53 Antikörper)-dependent manner.
reduction of VRK1 activity causes a delay in meiotic progression during oogenesis
VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance
Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.
These findings collectively support a role of VRK1 as a novel mitotic histone H3 (zeige HIST3H3 Antikörper) kinase in mammals.
This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.
vaccinia related kinase 1
, serine/threonine-protein kinase VRK1
, serine/threonine-protein kinase VRK1-like
, vaccinia virus B1R-related kinase 1
, vaccinia-related kinase 1
, serine/threonine-protein kinase 51PK