anti-Vaccinia Related Kinase 1 (VRK1) Antikörper

VRK1 encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases.

Alle Antikörper anzeigen Gen GeneID UniProt
Anti-Human VRK1 VRK1 7443 Q99986
Anti-Maus VRK1 VRK1 22367 Q80X41
Anti-Ratte VRK1 VRK1 362779  
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Top anti-Vaccinia Related Kinase 1 Antikörper auf antikoerper-online.de

Showing 10 out of 77 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Western Blot: VRK1 Antibody  - Analysis in human cell line HL-60. Immunocytochemistry/Immunofluorescence: VRK1 Antibody  - Immunofluorescent staining of human cell line U-251 MG shows localization to nucleoplasm. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$491.63
Details
Human Maus Unkonjugiert IF, IP, IHC, ELISA, WB 100 μg Anmelden zum Anzeigen 9 bis 11 Tage
$478.46
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of VRK1 expression in rat thymus extract (lane 1) and JURKAT whole cell lysates (lane 2). VRK1 at 55KD was detected using rabbit anti- VRK1 Antigen Affinity purified polyclonal antibody at0.5 μg/mL. The blot was developed using chemiluminescence (ECL) method Western blot analysis of VRK1 expression in rat thymus extract ( Lane 1) and JURKAT whole cell lysates ( Lane 2). VRK1 at 55KD was detected using rabbit anti- VRK1 Antigen Affinity purified polyclonal antibody (Catalog # ) at0.5 ??g/mL. The blot was developed using chemiluminescence (ECL) method (Catalog # EK1002). 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Kaninchen Unkonjugiert WB The anti-VRK1 Pab (ABIN391605) is used in Western blot to detect VRK1 in mouse lung tissue lysate (Lane 1) and HL-60 cell lysate (Lane 2). Western blot analysis of VRK1 (arrow) using rabbit polyclonal VRK1 Antibody (E381) (ABIN391605). 293 cell lysates (2 µg/lane) either nontransfected (Lane 1) or transiently transfected (Lane 2) with the VRK1 gene. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Kaninchen Unkonjugiert EIA, WB The anti-VRK1 Pab is used in Western blot to detect VRK1 in mouse lung tissue lysate (Lane 1) and HL-60 cell lysate (Lane 2). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
$390.50
Details
Human Maus Unkonjugiert WB VRK1 Antibody (Center) (ABIN1882291) western blot analysis in Hela,HL-60 cell line lysates (35 µg/lane). This demonstrates the VRK1 antibody detected the VRK1 protein (arrow). 100 μL Anmelden zum Anzeigen 10 bis 11 Tage
$324.50
Details
Human Maus Unkonjugiert IF, IP, RNAi, ELISA, WB Western blot analysis of VRK1 over-expressed 293 cell line, cotransfected with VRK1 Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with VRK1 monoclonal antibody (M02) clone 4F9. GAPDH ( 36.1 kDa ) used as specificity and loading control. Detection limit for recombinant GST tagged VRK1 is approximately 0.1ng/ml as a capture antibody. 100 μg Anmelden zum Anzeigen 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert WB Western Blot at 1:2000 dilution Lane 1: Jurkat whole cell lysates Lane 2: 293T/17 whole cell lysates Lane 3: MCF-7 whole cell lysates Lysates/proteins at 20 ug per lane. 400 μL Anmelden zum Anzeigen 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of extracts of various cells, using VRK1 antibody. Immunohistochemistry of paraffin-embedded rat lung using VRK1 antibody at dilution of 1:100 (40x lens). 100 μL Anmelden zum Anzeigen 16 Days
$334.02
Details
Human Kaninchen Unkonjugiert ICC, IHC, WB Figure.DAB staining on IHC-P. Samples: Human Tissue 100 μg Anmelden zum Anzeigen 13 bis 16 Tage
$350.00
Details

Am meisten referenzierte anti-Vaccinia Related Kinase 1 Antikörper

  1. Human Polyclonal VRK1 Primary Antibody für ICC, IF - ABIN4365869 : Sanz-García, Monsalve, Sevilla, Lazo: Vaccinia-related kinase 1 (VRK1) is an upstream nucleosomal kinase required for the assembly of 53BP1 foci in response to ionizing radiation-induced DNA damage. in The Journal of biological chemistry 2012 (PubMed)
    Show all 6 Pubmed References

  2. Human Monoclonal VRK1 Primary Antibody für WB - ABIN1882291 : Barcia, López-Borges, Vega, Lazo: Kinetic properties of p53 phosphorylation by the human vaccinia-related kinase 1. in Archives of biochemistry and biophysics 2002 (PubMed)
    Show all 5 Pubmed References

Weitere Antikörper gegen Vaccinia Related Kinase 1 Interaktionspartner

Caenorhabditis elegans (C. elegans) Vaccinia Related Kinase 1 (VRK1) Interaktionspartner

  1. vrk-1 has a role in early uterine development in Caenorhabditis elegans

  2. By coordinating VRK-1- and PP2A-mediated signaling on BAF, Lem4 and LEM-4L (Y55F3BR.8) controls postmitotic nuclear envelope formation in a function conserved from worms to humans.

  3. Genome-wide analysis of germ cell proliferation in C. elegans identifies vrk-1 as a key regulator of cep-1/p53 (zeige TP53 Antikörper).

  4. Data show that expression of the fibroblast growth factor-like protein EGL-17 and its receptor EGL-15 is reduced in vrk-1 mutants, suggesting that VRK-1 might act at least partially through activation of FGF signaling.

Human Vaccinia Related Kinase 1 (VRK1) Interaktionspartner

  1. this study not only provides a resource for investigating the unidentified functions of VRK1/VRK3, but also an insight into the regulatory roles of VRK1/VRK3 in biological processes.

  2. Block the activation of the VRK1 promoter by Sox2 (zeige SOX2 Antikörper).

  3. VRK1 and BANF1 (zeige BANF1 Antikörper) yielded AUCs of 0.790 and 0.735, respectively.

  4. VRK1 AND VRK2 (zeige VRK2 Antikörper) expression are predictive of tumor response to neoadjuvant chemoradiation therapy in rectal adenocarcinoma.

  5. VRK1 was lowly expressed in adherent MM cells and highly expressed in suspended cells. In addition, VRK1 was positively correlated with the proliferation of MM cells by regulating the expression of cell cycle-related protein, such as cyclinD1, CDK2 (zeige CDK2 Antikörper) and p27(kip1 (zeige CDKN1B Antikörper)).

  6. we conclude that VRK1 may be a candidate prognostic biomarker as well as a potential therapeutical target of hepatocellular carcinoma

  7. VRK1 may act as a tumor promoter by controlling the level of cell cycle regulators associated with G1/S transition and could potentially serve as a therapeutic target and/or prognostic biomarker for HCC (zeige FAM126A Antikörper).

  8. VRK1 is a novel regulator of CBs (zeige CBS Antikörper) dynamics and stability in cell cycle by protecting coilin (zeige COIL Antikörper) from ubiquitination and degradation in the proteasome, and propose a model of CB dynamics.

  9. VRK1 regulation of NBS1 (zeige NBN Antikörper) contributes to the stability of the repair complex and permits the sequential steps in DNA damage response.

  10. VRK1 is a novel chromatin component that reacts to its alterations and participates very early in DNA damage response, functioning by itself or in cooperation with Ataxia Telangiectasia Mutated (zeige ATM Antikörper) Proteins.

Mouse (Murine) Vaccinia Related Kinase 1 (VRK1) Interaktionspartner

  1. VRK1 self-represses its activity to phosphorylate PXR (zeige NR1I2 Antikörper) through cyclin-dependent kinase 2 (CDK2 (zeige CDK2 Antikörper)) in high glucose conditions, resulting in the repression of the PCK1 (zeige PCK1 Antikörper) gene. This PXR (zeige NR1I2 Antikörper) phosphorylation was also observed in fasting mouse livers. Thus, the VRK1-CDK2 (zeige CDK2 Antikörper)-PXR (zeige NR1I2 Antikörper)-PP2Calpha (zeige PPM1A Antikörper)-SGK2 (zeige SGK2 Antikörper) pathway can be a novel physiological cell signaling that regulates gluconeogenesis in response to glucose.

  2. VRK1 deficiency in human and mouse leads to downregulation of amyloid-beta precursor protein (APP (zeige APP Antikörper)). APP (zeige APP Antikörper) overexpression rescues the phenotype caused by Vrk1 knockdown, suggesting that VRK1 affects neuronal migration through an APP (zeige APP Antikörper)-dependent mechanism.

  3. Data suggest that VRK1 is required for both follicle development and oocyte growth in mammalian female reproduction system.

  4. Protein kinase (zeige CDK7 Antikörper) Cdelta regulates phosphorylation and down-regulation of Vaccinia-related kinase 1 (VRK1), thereby contributing to cell cycle arrest and apoptotic cell death in a p53 (zeige TP53 Antikörper)-dependent manner.

  5. reduction of VRK1 activity causes a delay in meiotic progression during oogenesis

  6. VRK1 is required for the proliferation and differentiation of undifferentiated spermatogonia, which are essential for spermatogenic cell maintenance

  7. Depletion of VRK1 leads to progressive male infertility as a result of a cessation of spermatogonial proliferation.

  8. These findings collectively support a role of VRK1 as a novel mitotic histone H3 (zeige HIST3H3 Antikörper) kinase in mammals.

Vaccinia Related Kinase 1 (VRK1) Antigen-Profil

Protein Überblick

This gene encodes a member of the vaccinia-related kinase (VRK) family of serine/threonine protein kinases. This gene is widely expressed in human tissues and has increased expression in actively dividing cells, such as those in testis, thymus, fetal liver, and carcinomas. Its protein localizes to the nucleus and has been shown to promote the stability and nuclear accumulation of a transcriptionally active p53 molecule and, in vitro, to phosphorylate Thr18 of p53 and reduce p53 ubiquitination. This gene, therefore, may regulate cell proliferation. This protein also phosphorylates histone, casein, and the transcription factors ATF2 (activating transcription factor 2) and c-JUN.

Genbezeichner und Symbole assoziert mit VRK1

  • vaccinia related kinase 1 L homeolog (vrk1.L) Antikörper
  • vaccinia related kinase 1 (vrk1) Antikörper
  • vaccinia related kinase 1 (VRK1) Antikörper
  • Serine/threonine-protein kinase VRK1 (vrk-1) Antikörper
  • vaccinia related kinase 1 (Vrk1) Antikörper
  • 51PK Antikörper
  • MGC64390 Antikörper
  • MGC75762 Antikörper
  • PCH1 Antikörper
  • PCH1A Antikörper
  • VRK1 Antikörper
  • wu:fe16f06 Antikörper
  • zgc:56266 Antikörper

Bezeichner auf Proteinebene für VRK1

vaccinia related kinase 1 , serine/threonine-protein kinase VRK1 , serine/threonine-protein kinase VRK1-like , vaccinia virus B1R-related kinase 1 , vaccinia-related kinase 1 , serine/threonine-protein kinase 51PK

GENE ID SPEZIES
380541 Xenopus laevis
394552 Xenopus (Silurana) tropicalis
423443 Gallus gallus
453148 Pan troglodytes
490848 Canis lupus familiaris
704798 Macaca mulatta
100195811 Salmo salar
100401786 Callithrix jacchus
100340357 Oryctolagus cuniculus
174004 Caenorhabditis elegans
7443 Homo sapiens
22367 Mus musculus
362779 Rattus norvegicus
618880 Bos taurus
100157930 Sus scrofa
406694 Danio rerio
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