anti-Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Antikörper

The protein encoded by TDP1 is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. Zusätzlich bieten wir Ihnen TDP1 Proteine (11) und TDP1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TDP1 55775 Q9NUW8
TDP1 104884  
TDP1 314380 Q4G056
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Top anti-TDP1 Antikörper auf antikoerper-online.de

Showing 10 out of 97 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Tdp1 Antibody Titration: 1.0 ug/ml Positive Control: Mouse Brain 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB Host: Rabbit Target Name: Tdp1 Sample Type: Mouse Lung lysates Antibody Dilution: 1.0ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Human Maus Unkonjugiert EIA, IHC (p), WB 0.1 mL Anmelden zum Anzeigen 6 bis 8 Tage
$412.50
Details
Human Maus Unkonjugiert ELISA, WB 50 μg Anmelden zum Anzeigen 2 bis 3 Tage
$315.00
Details
Human Maus Unkonjugiert ELISA, WB Detection limit for recombinant GST tagged TDP1 is approximately 0.1 ng/mL as a capture antibody. 0.1 mg Anmelden zum Anzeigen 8 bis 11 Tage
$450.00
Details
Human Kaninchen Unkonjugiert IF, IP, WB Immunoprecipitation of TDP1 transfected lysate using anti-TDP1 MaxPab rabbit polyclonal antibody and Protein A Magnetic Bead , and immunoblotted with TDP1 purified MaxPab mouse polyclonal antibody (B01P) . Western Blot analysis of TDP1 expression in transfected 293T cell line by TDP1 MaxPab polyclonal antibody.<br><br>Lane 1: TDP1 transfected lysate(68.40 KDa).<br>Lane 2: Non-transfected lysate.<br> 100 μL Anmelden zum Anzeigen 11 bis 12 Tage
$425.71
Details
Human Kaninchen Unkonjugiert IHC (p), IP, IHC, PLA, WB Immunohistochemistry-Paraffin: TDP1 Antibody [ABIN2570872] - Section of human ovarian carcinoma. Dilution: 1:1,000 (0.2ug/ml). 0.1 mL Anmelden zum Anzeigen 7 bis 9 Tage
$556.31
Details
Human Maus Unkonjugiert IHC (p), ELISA, WB Human Small Intestine (formalin-fixed, paraffin-embedded) stained with antibody ABIN462272 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. Human Placenta (formalin-fixed, paraffin-embedded) stained with antibody ABIN462272 followed by biotinylated secondary antibody, alkaline phosphatase-streptavidin and chromogen. 50 μL Anmelden zum Anzeigen 7 bis 9 Tage
$484.00
Details
Human Maus Unkonjugiert WB HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY TDP1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 µg per lane) were separated by SDS-PAGE and immunoblotted with anti-TDP1. 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$482.90
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB ICC/IF Image Immunofluorescence analysis of methanol-fixed A431, using TDP1, antibody at 1:200 dilution. IHC-P Image Immunohistochemical analysis of paraffin-embedded human gastric, using TDP1, antibody at 1:100 dilution. 100 μL Anmelden zum Anzeigen 1 bis 2 Tage
$358.60
Details

TDP1 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
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Mouse (Murine)


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Rat (Rattus)


Am meisten referenzierte anti-TDP1 Antikörper

  1. Human Polyclonal TDP1 Primary Antibody für ELISA, WB - ABIN565920 : Katyal, el-Khamisy, Russell, Li, Ju, Caldecott, McKinnon: TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. in The EMBO journal 2007 (PubMed)
    Show all 5 Pubmed References

  2. Human Polyclonal TDP1 Primary Antibody für IHC (p), IP - ABIN257087 : Perego, Cossa, Tinelli, Corna, Carenini, Gatti, De Cesare, Ciusani, Zunino, Luison, Canevari, Zaffaroni, Beretta: Role of tyrosyl-DNA phosphodiesterase 1 and inter-players in regulation of tumor cell sensitivity to topoisomerase I inhibition. in Biochemical pharmacology 2011 (PubMed)
    Show all 2 Pubmed References

Weitere Antikörper gegen TDP1 Interaktionspartner

Arabidopsis thaliana Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Interaktionspartner

  1. AtTDP plays a clear role in the repair of topoisomerase I (zeige TOP1 Antikörper)-DNA complexes.

Human Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Interaktionspartner

  1. Data indicate a molecular basis for DNA 3'-end processing by tyrosyl-DNA phosphodiesterase (Tdp1).

  2. Expression of human Tdp1HisnucAla and Tdp1HisgabAsn mutants results in stabilization of the covalent TDP1-DNA intermediate and induces cytotoxicity.

  3. We show that two genes, TDP1, a tyrosyl-DNA-phosphdiesterase, and TAF12 (zeige TAF12 Antikörper), an RNA polymerase II (zeige 0 Antikörper) TATA-box binding factor, cause CIN (zeige PDXP Antikörper) when overexpressed in human cells. Using SDL screens in yeast, we identified a set of genes that when deleted specifically kill cells with high levels of Tdp1

  4. TDP1 participation in human non-homologous end joining (NHEJ) is mediated by interaction with XLF (zeige NHEJ1 Antikörper), and that TDP1-XLF (zeige NHEJ1 Antikörper) interactions and subsequent NHEJ events are regulated by phosphorylation of TDP1-S81.

  5. Mutations in TDP1 and APTX have been linked to Spinocerebellar ataxia with axonal neuropathy (SCAN1) and Ataxia-ocular motor apraxia 1 (AOA1), respectively, while mutations in PNKP are considered to be responsible for Microcephaly with seizures (MCSZ) and Ataxia-ocular motor apraxia 4 (AOA4).

  6. The data obtained suggest that PARP1 (zeige PARP1 Antikörper) and TDP1 bind in an antiparallel orientation; the N-terminus of the former protein interacts with the C-terminal domain of the latter.

  7. Tyrosyl-DNA-phosphodiesterase I (TDP1) participates in the removal and repair of stabilized-Top2alpha cleavage complexes in human cells.

  8. varying expression levels of TOP1 (zeige TOP1 Antikörper) and TDP1 polypeptides in multiple colorectal cancer cell lines and in clinical colorectal cancer samples, are reported.

  9. both TOP1 (zeige TOP1 Antikörper) and TDP1 were upregulated in the tumor tissue compared to the adjacent non-tumor tissue in non-small cell lung cancer tissue

  10. Density functional theory computations are used to acquire thermodynamic and kinetic data along the catalytic pathway, including the phosphoryl transfers of Tdp1 and subsequent hydrolysis.

Mouse (Murine) Tyrosyl-DNA Phosphodiesterase 1 (TDP1) Interaktionspartner

  1. These findings provide evidence for TDP1 as a novel mitochondrial enzyme.

  2. The interaction with Lig3alpha is promoted by serine 81 that is located within a putative S/TQ site in the N-terminus domain of TDP1.

  3. Data indicate that TDP1 is required for neural homeostasis and reveal a widespread requisite for TDP1 function in response to acutely elevated levels of DNA topoisomerase I (Top1 (zeige TOP1 Antikörper))-associated DNA strand breaks.

  4. This study provides a direct demonstration that Tdp1 repairs Topo I (zeige TOP1 Antikörper) covalent lesions in vivo and suggests that spinocerebellar ataxia with axonal neuropathy (SCAN1 (zeige CANT1 Antikörper)) arises from the recessive neomorphic mutation H493R.

  5. Tdp1(-/-) fibroblasts exhibited deficiencies in processing 3'-phosphotyrosyl single-strand breaks and 3'-phosphoglycolate double-strand breaks, but not 3 (zeige CNOT3 Antikörper)'-phosphoglycolate single-strand breaks.

TDP1 Antigen-Profil

Protein Überblick

The protein encoded by this gene is involved in repairing stalled topoisomerase I-DNA complexes by catalyzing the hydrolysis of the phosphodiester bond between the tyrosine residue of topoisomerase I and the 3-prime phosphate of DNA. This protein may also remove glycolate from single-stranded DNA containing 3-prime phosphoglycolate, suggesting a role in repair of free-radical mediated DNA double-strand breaks. This gene is a member of the phospholipase D family and contains two PLD phosphodiesterase domains. Mutations in this gene are associated with the disease spinocerebellar ataxia with axonal neuropathy (SCAN1). While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. These two represent the major variants of this gene and encode the same isoform.

Genbezeichner und Symbole assoziert mit TDP1

  • tyrosyl-DNA phosphodiesterase 1 (TDP1) Antikörper
  • tyrosyl-DNA Phosphodiesterase (Tdp1) (Tc00.1047053511191.10) Antikörper
  • tyrosyl-DNA phosphodiesterase 1 (Tdp1) Antikörper
  • tyrosyl-DNA phosphodiesterase 1 L homeolog (tdp1.L) Antikörper
  • tyrosyl-DNA phosphodiesterase 1 (tdp1) Antikörper
  • tyrosyl-DNA phosphodiesterase-like protein (TDP1) Antikörper
  • tyrosyl-DNA phosphodiesterase 1 (PTRG_11198) Antikörper
  • tyrosyl-DNA phosphodiesterase 1 (MCYG_02121) Antikörper
  • tyrosyl-DNA phosphodiesterase 1 (MGYG_03035) Antikörper
  • 2810481F14Rik Antikörper
  • 4921509N21Rik Antikörper
  • AI838772 Antikörper
  • AW493413 Antikörper
  • E430034L06Rik Antikörper
  • F8M21.60 Antikörper
  • F8M21_60 Antikörper
  • MGC83708 Antikörper
  • MLZ-501 Antikörper
  • SCAN1 Antikörper
  • TDP1 Antikörper
  • tyrosyl-DNA phosphodiesterase 1 Antikörper

Bezeichner auf Proteinebene für TDP1

tyr-DNA phosphodiesterase 1 , tyrosyl-DNA Phosphodiesterase (Tdp1) , protein expressed in male leptotene and zygotene spermatocytes 501 , tyrosyl-DNA phodphodiesterase 1 , tyrosyl-DNA phosphodiesterase 1 , tyrosyl-DNA phosphodiesterase 1-like , Tyrosyl-DNA phosphodiesterase 1-like protein

GENE ID SPEZIES
55775 Homo sapiens
3534433 Trypanosoma cruzi strain CL Brener
104884 Mus musculus
314380 Rattus norvegicus
423403 Gallus gallus
446983 Xenopus laevis
453096 Pan troglodytes
517053 Bos taurus
571485 Danio rerio
695338 Macaca mulatta
734106 Xenopus (Silurana) tropicalis
831369 Arabidopsis thaliana
6349511 Pyrenophora tritici-repentis Pt-1C-BFP
9229242 Arthroderma otae CBS 113480
10030819 Arthroderma gypseum CBS 118893
100388128 Callithrix jacchus
100432320 Pongo abelii
100593301 Nomascus leucogenys
100724667 Cavia porcellus
100062463 Equus caballus
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