anti-Topoisomerase (DNA) III beta (TOP3B) Antikörper

TOP3B encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. Zusätzlich bieten wir Ihnen TOP3B Proteine (5) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TOP3B 8940 O95985
TOP3B 21976 Q9Z321
TOP3B 287930  
Direkt bei antikoerper-online bestellen
  • +1 877 302 8632
  • +1 888 205 9894 (toll-free)
  • Online bestellen
  • orders@antikoerper-online.de

Top anti-TOP3B Antikörper auf antikoerper-online.de

Showing 10 out of 54 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Human Kaninchen Unkonjugiert EIA, WB TOP3B Antibody (C-term) western blot analysis in mouse bladder tissue lysates (35 µg/lane). This demonstrates the TOP3B antibody detected the TOP3B protein (arrow). 0.4 mL 6 bis 8 Tage
$484.00
Details
Human Kaninchen Unkonjugiert ELISA, WB Western blot analysis of extracts from HepG2/COLO205/HuvEc cells, using TOP3B Antibody. The lane on the right is treated with the synthesized peptide. 100 μg 2 bis 3 Tage
$302.50
Details
Human Kaninchen Unkonjugiert ELISA, ICC, IF, WB ABIN6274143 staining HepG2 cells by IF/ICC. The sample were fixed with PFA and permeabilized in 0.1% Triton X-100,then blocked in 10% serum for 45 minutes at 25°C. The primary antibody was diluted at 1/200 and incubated with the sample for 1 hour at 37°C. An Alexa Fluor 594 conjugated goat anti-rabbit IgG (H+L) antibody(Cat.# S0006), diluted at 1/600, was used as secondary antibody. Western blot analysis of extracts from HepG2 cells using TOP3B antibody 100 μL 11 bis 12 Tage
$390.77
Details
Human Kaninchen Unkonjugiert WB Western blot analysis in mouse bladder tissue lysates (35ug/lane). 400 μL 2 bis 3 Tage
$515.63
Details
Human Kaninchen Unkonjugiert WB Western blot analysis of extracts of various cells, using TOP3B antibody. 100 μL 11 bis 13 Tage
$366.77
Details
Human Maus Unkonjugiert RNAi, ELISA, WB TOP3B monoclonal antibody (M01), clone 4F11 Western Blot analysis of TOP3B expression in K-562 . Western blot analysis of TOP3B over-expressed 293 cell line, cotransfected with TOP3B Validated Chimera RNAi (Lane 2) or non-transfected control (Lane 1). Blot probed with TOP3B monoclonal antibody (M01), clone 4F11. GAPDH ( 36.1 kDa ) used as specificity and loading control. 100 μg 11 bis 12 Tage
$440.00
Details
Human Maus Unkonjugiert IF, ELISA, WB Western Blot analysis of TOP3B expression in transfected 293T cell line by TOP3B monoclonal antibody (M05), clone 4H7.Lane 1: TOP3B transfected lysate(96.662 KDa).Lane 2: Non-transfected lysate. Immunofluorescence of monoclonal antibody to TOP3B on HeLa cell. [antibody concentration 10 ug/ml] 100 μg 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert IHC (p), WB 0.1 mg 6 bis 8 Tage
$434.50
Details
Human Maus Unkonjugiert WB Western Blot analysis of TOP3B expression in transfected 293T cell line by TOP3B MaxPab polyclonal antibody.Lane 1: TOP3B transfected lysate(94.82 KDa).Lane 2: Non-transfected lysate. 50 μL 11 bis 12 Tage
$440.00
Details
Human Kaninchen Unkonjugiert IHC, WB Western blot analysis of HepG2 cell lysate with TOP3B polyclonal antibody . 100 μL 11 bis 12 Tage
$460.00
Details

Weitere Antikörper gegen TOP3B Interaktionspartner

Human Topoisomerase (DNA) III beta (TOP3B) Interaktionspartner

  1. Findings indicate the regulation of DNA topoisomerase III beta (TOP3B) activity by post-translational modification (PTM).

  2. Structural basis of the interaction between TOP3B and the TDRD3 auxiliary factor has been reported.

  3. Results identified TOP3B gene deletion as candidate gene in the etiology of neurodevelopmental disorders including juvenile myoclonic epilepsy.

  4. Top3beta mutants lacking either its RNA-binding domain or catalytic residue fail to promote synapse formation, suggesting that Top3beta requires both its mRNA-binding and catalytic activity to facilitate neurodevelopment.

  5. Top3b proteins from several animals associate with polyribosomes, which are units of mRNA translation, whereas the Top3 homologs from E. coli and yeast lack the association. The Top3b-polyribosome association requires TDRD3, which directly interacts with Top3beta and is present in animals but not bacteria or yeast.

  6. TOP3B promotes transcription, protects against DNA damage, and reduces the frequency of chromosomal translocations.

  7. Topoisomerase IIIbeta expression can be a useful marker in assessing the prognosis of patients with breast cancer and is an independent predictor of survival.

  8. the positive regulatory region including the 5'GGAACC3' core element is essential for efficient expression of the DNA topoisomerase III beta gene

  9. Two isoforms of human DNA topoisomerase IIIbeta were expressed in HeLa cells. Isoform 1 was localized to the nucleus and associated with chromosomes during metaphase and anaphase. Isoform 2 was found in the cytoplasm.

Mouse (Murine) Topoisomerase (DNA) III beta (TOP3B) Interaktionspartner

  1. This study indicated a role for TOP3beta in mRNA metabolism and suggest that it is involved in neurodevelopmental disorders.

  2. DNA topoisomerase III beta has a role in infertility and aneuploidy

  3. Chromosomal abnormalities in top3beta(-/-) mice might lead to a persistent increase in apoptotic cells, which might in turn lead to the progression of autoimmunity

  4. suggest an unanticipated role for Top3beta beyond DNA repair in the activation of cellular responses to DNA damage

TOP3B Antigen-Profil

Protein Überblick

This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This enzyme catalyzes the transient breaking and rejoining of a single strand of DNA which allows the strands to pass through one another, thus relaxing the supercoils and altering the topology of DNA. The enzyme interacts with DNA helicase SGS1 and plays a role in DNA recombination, cellular aging and maintenance of genome stability. Alternative splicing of the C-terminus of this gene results in three transcript variants which have distinct tissue specificity\; however, not all variants have been fully described.

Genbezeichner und Symbole assoziert mit TOP3B

  • DNA topoisomerase III beta (TOP3B) Antikörper
  • topoisomerase (DNA) III beta (Top3b) Antikörper
  • DNA topoisomerase III beta (Top3b) Antikörper
  • DNA topoisomerase III beta L homeolog (top3b.L) Antikörper
  • top3b Antikörper
  • TOP3B1 Antikörper

Bezeichner auf Proteinebene für TOP3B

DNA topoisomerase 3-beta-1 , DNA topoisomerase III beta-1 , topoisomerase III beta , Topo III beta , topoisomerase (DNA) III beta , DNA topoisomerase III beta L homeolog , topoisomerase (DNA) III beta L homeolog , LOW QUALITY PROTEIN: DNA topoisomerase 3-beta-1

GENE ID SPEZIES
8940 Homo sapiens
21976 Mus musculus
287930 Rattus norvegicus
537418 Bos taurus
398564 Xenopus laevis
100155140 Sus scrofa
477576 Canis lupus familiaris
Ausgewählte Anbieter für anti-TOP3B (TOP3B) Antikörper
Haben Sie etwas anderes gesucht?