anti-TNF Receptor-Associated Protein 1 (TRAP1) Antikörper

TRAP1 encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. Zusätzlich bieten wir Ihnen TNF Receptor-Associated Protein 1 Proteine (10) und TNF Receptor-Associated Protein 1 Kits (8) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TRAP1 10131 Q12931
TRAP1 68015 Q9CQN1
TRAP1 287069 Q5XHZ0
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Top anti-TNF Receptor-Associated Protein 1 Antikörper auf antikoerper-online.de

Showing 10 out of 291 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Lieferzeit Preis Details
Hund Kaninchen Unkonjugiert WB WB Suggested Anti-TRAP1 Antibody Titration: 1.0 ug/ml Positive Control: Hela Whole Cell TRAP1 is supported by BioGPS gene expression data to be expressed in HeLa 100 μL 2 bis 3 Tage
$289.00
Details
Hund Kaninchen Unkonjugiert IHC, WB Human kidney WB Suggested Anti-TRAP1 Antibody Titration: 0.5ug/ml ELISA Titer: 1:312500 Positive Control: HepG2 cell lysate TRAP1 is supported by BioGPS gene expression data to be expressed in HepG2 100 μL 2 bis 3 Tage
$229.00
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC (p), WB WB Image Sample (50 ug of whole cell lysate) A: Mouse brain 7.5% SDS PAGE antibody diluted at 1:1000 ICC/IF Image TRAP1 antibody detects TRAP1 protein at mitochondria by immunofluorescent analysis. Sample: HeLa cells were fixed in ice-cold MeOH for 5 min. Green: TRAP1 protein stained by TRAP1 antibody , diluted at 1:1000. Blue: Hoechst 33342 staining. Scale bar = 10 μm. 100 μL 3 bis 4 Tage
$466.18
Details
Human Kaninchen Unkonjugiert IHC (p), WB Anti- TRAP1 Picoband antibody, IHC(P) IHC(P): Human Intestinal Cancer Tissue 100 μg 4 bis 6 Tage
$280.00
Details
Hund Maus Unkonjugiert FACS, IF, IHC, IHC (p), WB 100 μL 11 bis 14 Tage
$522.50
Details
Hund Maus Unkonjugiert IF, IHC, IHC (p), WB 100 μL 11 bis 14 Tage
$522.50
Details
Human Kaninchen FITC ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-TRAP1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-TRAP1 Polyclonal Antibody  at 1:120 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-TRAP1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Western blot analysis of Human Cervical Cancer cell lysates (HeLa) showing detection of ~75 kDa TRAP1 protein using Rabbit Anti-TRAP1 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Human Cervical Cancer cell lysates (HeLa). Load: 12 µg. Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-TRAP1 Polyclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Goat Anti-Rabbit IgG: HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 5 min at RT. Predicted/Observed Size: ~75 kDa. Other Band(s): 100 kDa. 100 μg 3 bis 4 Tage
$477.10
Details
Human Kaninchen APC ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-TRAP1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-TRAP1 Polyclonal Antibody  at 1:120 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-TRAP1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Western blot analysis of Human Cervical Cancer cell lysates (HeLa) showing detection of ~75 kDa TRAP1 protein using Rabbit Anti-TRAP1 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Human Cervical Cancer cell lysates (HeLa). Load: 12 µg. Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-TRAP1 Polyclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Goat Anti-Rabbit IgG: HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 5 min at RT. Predicted/Observed Size: ~75 kDa. Other Band(s): 100 kDa. 100 μg 3 bis 4 Tage
$486.20
Details
Human Kaninchen PerCP ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-TRAP1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-TRAP1 Polyclonal Antibody  at 1:120 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-TRAP1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Western blot analysis of Human Cervical Cancer cell lysates (HeLa) showing detection of ~75 kDa TRAP1 protein using Rabbit Anti-TRAP1 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Human Cervical Cancer cell lysates (HeLa). Load: 12 µg. Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-TRAP1 Polyclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Goat Anti-Rabbit IgG: HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 5 min at RT. Predicted/Observed Size: ~75 kDa. Other Band(s): 100 kDa. 100 μg 3 bis 4 Tage
$486.20
Details
Human Kaninchen Atto 594 ICC, IF, WB Immunocytochemistry/Immunofluorescence analysis using Rabbit Anti-TRAP1 Polyclonal Antibody . Tissue: Heat Shocked HeLa Cells. Species: Human. Fixation: 2% Formaldehyde for 20 min at RT. Primary Antibody: Rabbit Anti-TRAP1 Polyclonal Antibody  at 1:120 for 12 hours at 4°C. Secondary Antibody: FITC Goat Anti-Rabbit (green) at 1:200 for 2 hours at RT. Counterstain: DAPI (blue) nuclear stain at 1:40000 for 2 hours at RT. Localization: Mitochondrion. Mitochondrion inner membrane. Mitochondrion matrix. Magnification: 100x. (A) DAPI (blue) nuclear stain. (B) Anti-TRAP1 Antibody. (C) Composite. Heat Shocked at 42°C for 1h. Western blot analysis of Human Cervical Cancer cell lysates (HeLa) showing detection of ~75 kDa TRAP1 protein using Rabbit Anti-TRAP1 Polyclonal Antibody . Lane 1: Molecular Weight Ladder (MW). Lane 2: Human Cervical Cancer cell lysates (HeLa). Load: 12 µg. Block: 5% Skim Milk in 1X TBST. Primary Antibody: Rabbit Anti-TRAP1 Polyclonal Antibody  at 1:1000 for 2 hours at RT. Secondary Antibody: Goat Anti-Rabbit IgG: HRP at 1:2000 for 60 min at RT. Color Development: ECL solution for 5 min at RT. Predicted/Observed Size: ~75 kDa. Other Band(s): 100 kDa. 100 μg 3 bis 4 Tage
$487.50
Details

Am meisten referenzierte anti-TNF Receptor-Associated Protein 1 Antikörper

  1. Human Monoclonal TRAP1 Primary Antibody für ICC, IF - ABIN152714 : Hamacher-Brady, Choe, Krijnse-Locker, Brady: Intramitochondrial recruitment of endolysosomes mediates Smac degradation and constitutes a novel intrinsic apoptosis antagonizing function of XIAP E3 ligase. in Cell death and differentiation 2014 (PubMed)
    Show all 2 Pubmed References

  2. Human Polyclonal TRAP1 Primary Antibody für WB - ABIN926851 : Matthies, Newman, Hodzic, Wingett: Differential regulation of soluble and membrane CD40L proteins in T cells. in Cellular immunology 2006 (PubMed)

  3. Human Polyclonal TRAP1 Primary Antibody für IF (p) - ABIN686654 : Lettini, Sisinni, Condelli, Matassa, Simeon, Maddalena, Gemei, Lopes, Vita, Del Vecchio, Esposito, Landriscina: TRAP1 regulates stemness through Wnt/β-catenin pathway in human colorectal carcinoma. in Cell death and differentiation 2016 (PubMed)

Weitere Antikörper gegen TNF Receptor-Associated Protein 1 Interaktionspartner

Human TNF Receptor-Associated Protein 1 (TRAP1) Interaktionspartner

  1. Results demonstrated that TRAP1 gene polymorphisms may be associated with the systemic lupus erythematosus (SLE) susceptibility and glucocorticoids sensitivity in SLE patients.

  2. In the presence of magnesium, ATP hydrolysis by TRAP1, as with other Hsp90s, was noncooperative, whereas calcium binding resulted in cooperative hydrolysis by the two protomers within the Hsp90 dimer. The structural data suggested a mechanism for this cooperative behavior.

  3. Both redox imbalance and IHG-1 stimulate TGF-beta signalling. IHG-1, HSPA5 and YBX1 all show increased expression in diabetic nephropathy, chronic kidney disease and in the Unilateral Ureteral Obstruction model of kidney fibrosis. Increased IHG-1 expression in UUO correlated with loss of TRAP1 expression. IHG-1 may target TRAP1 for degradation.

  4. results show that even though TRAP1 depletion affects both normal MRC-5 and tumour A549 cell proliferation, inhibition of autophagy per se led to a decrease in tumour cell mass, while having a reduced effect on the normal cell line. The strategy of targeting TRAP1 in NSCLC shows future potential therapeutic applications.

  5. Here, the authors show that rather than being cooperative or independent, ATP hydrolysis on the two protomers is sequential and deterministic. Moreover, dimer asymmetry sets up differential hydrolysis rates for each protomer, such that the buckled conformation favors ATP hydrolysis.

  6. TRAP1 inhibition may be regarded as potential strategy to target specific features of human thyroid cancers, i.e., cell proliferation and resistance to apoptosis.

  7. TRAP1 regulates stemness and Wnt/beta-catenin pathway in colorectal cancer.

  8. data show that TRAP1 acts downstream of PINK1 and HTRA2 for mitochondrial fine tuning, whereas TRAP1 loss of function leads to reduced control of energy metabolism, ultimately impacting mitochondrial membrane potential.

  9. This review summarizes how metabolism, chemoresistance, inflammation, and epithelial-to-mesenchymal transition are strictly interconnected, and how TRAP1 stays at the crossroads of these processes, thus shedding new lights on molecular networks at the basis of ovarian cancer. [review]

  10. The crystal structure of a human TRAP1NM dimer is presented, featuring an intact N-domain and M-domain structure, bound to adenosine 5'-beta,gamma-imidotriphosphate.

  11. These data suggest that TRAP1 protein network may provide a prognostic signature in human metastatic colorectal carcinomas

  12. TRAP1 is relevant in the control of key cell cycle regulators in tumor cells. TRAP1/TBP7 quality control of CDK1 and MAD2 contributes mechanistically to the regulation of mitotic entry and transit.

  13. TRAP1 is often deleted in high-grade serous ovarian cancer patients.

  14. TRAP1 increases cell proliferation, reduces apoptosis, and promotes cell invasion without changes in mitochondrial bioenergetics. Therefore, TRAP1 is a driver of prostate cancer in vivo and an "actionable" therapeutic target.

  15. overexpression of TRAP1 might contribute to tumor cell local invasion of colorectal cancer

  16. Increased TRAP1 expression was significantly associated with EOC stages.

  17. Overexpression of TRAP1 in breast cancer cells causes mitochondrial fusion, triggers mitochondria to form tubular networks, and suppresses cell migration and invasion in vitro and in vivo. These data link TRAP1-regulated mitochondrial dynamics and function with tumorigenesis in breast cancer.

  18. TRAP1 is highly expressed in kidney cancer and correlates with patients prognosis

  19. TRAP1 is a downstream effector of BRAF cytoprotective pathway in mitochondria and TRAP1 targeting may represent a novel strategy to improve the activity of proapoptotic agents in BRAF-driven CRC cells.

  20. Our results indicate that GRP94 and TRAP1 might contribute more to the carcinogenesis or biology of SCLC than HSP90alpha and HSP90beta

Mouse (Murine) TNF Receptor-Associated Protein 1 (TRAP1) Interaktionspartner

  1. show that TRAP1 could protect the mitochondrial structure in renal tubular epithelial cells; maintain the levels of mitochondrial membrane potential, ATP, and mitochondrial DNA copy number

  2. TRAP1 increases cell proliferation, reduces apoptosis, and promotes cell invasion without changes in mitochondrial bioenergetics. Therefore, TRAP1 is a driver of prostate cancer in vivo and an "actionable" therapeutic target.

  3. Data show that the overexpression of heat shock protein 75 (Hsp75) decreased neural stem cells (NSCs) apoptosis and preserved mitochondrial membrane potential.

  4. TRAP-1-/- mice are viable and show reduced incidence of age-associated pathologies. Loss of TRAP-1 upregulates oxidative phosphorylation and glycolysis transcriptomes.

  5. overexpression of TRAP1 leads to mitochondrial aberrations, including an increase in basal ROS levels and decrease in mitochondrial biogenesis, together with a decrease in peroxisome proliferator-activated receptor gamma coactivator-1alpha mRNA levels

  6. Early mesangial nephritis initiates a cascade of inflammatory signals that lead to up-regulation of Trap1 and a consequent down-regulation of renal DNaseI by transcriptional interference.

  7. TRAP1 regulates a metabolic switch between oxidative phosphorylation and aerobic glycolysis in immortalized mouse fibroblasts.

  8. These data identify TRAP-1 as a novel mitochondrial survival factor differentially expressed in localized and metastatic prostate cancer compared with normal prostate.

Zebrafish TNF Receptor-Associated Protein 1 (TRAP1) Interaktionspartner

  1. In the presence of magnesium, ATP hydrolysis by TRAP1, as with other Hsp90s, was noncooperative, whereas calcium binding resulted in cooperative hydrolysis by the two protomers within the Hsp90 dimer. The structural data suggested a mechanism for this cooperative behavior.

  2. The crystal structure of full-length TRAP1, the mitochondrial Hsp90 molecular chaperone, in a catalytically active closed state is presented.

TNF Receptor-Associated Protein 1 (TRAP1) Antigen-Profil

Protein Überblick

This gene encodes a mitochondrial chaperone protein that is member of the heat shock protein 90 (HSP90) family. The encoded protein has ATPase activity and interacts with tumor necrosis factor type I. This protein may function in regulating cellular stress responses. Alternate splicing results in multiple transcript variants.

Genbezeichner und Symbole assoziert mit TRAP1

  • TNF receptor associated protein 1 (TRAP1) Antikörper
  • TNF receptor-associated protein 1 (Trap1) Antikörper
  • TNF receptor-associated protein 1 (TRAP1) Antikörper
  • TNF receptor associated protein 1 (Trap1) Antikörper
  • TNF receptor-associated protein 1 (trap1) Antikörper
  • 2410002K23Rik Antikörper
  • fc85a11 Antikörper
  • HSP 75 Antikörper
  • HSP75 Antikörper
  • HSP90L Antikörper
  • TRAP-1 Antikörper
  • wu:fc85a11 Antikörper

Bezeichner auf Proteinebene für TRAP1

TNFR-associated protein 1 , heat shock protein 75 kDa, mitochondrial , tumor necrosis factor type 1 receptor-associated protein , HSP 75 , TRAP-1 , tumor necrosis factor type 1 receptor associated protein

GENE ID SPEZIES
10131 Homo sapiens
68015 Mus musculus
287069 Rattus norvegicus
416666 Gallus gallus
514472 Bos taurus
490032 Canis lupus familiaris
100718722 Cavia porcellus
571959 Danio rerio
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