anti-T-Box 5 (TBX5) Antikörper

TBX5 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. Zusätzlich bieten wir Ihnen T-Box 5 Proteine (7) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
TBX5 6910 Q99593
TBX5 21388 P70326
TBX5 304514 Q5I2P1
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Top anti-T-Box 5 Antikörper auf

Showing 10 out of 70 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB WB Suggested Anti-TBX5 Antibody Titration:  0.2-1 ug/ml  ELISA Titer:  1:312500  Positive Control:  HepG2 cell lysate Immunohistochemistry with Human Brain, cortex tissue at an antibody concentration of 5.0ug/ml using anti-TBX5 antibody 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Rind (Kuh) Kaninchen Unkonjugiert IHC, WB WB Suggested Anti-TBX5 Antibody Titration:  0.5ug/ml  Positive Control:  Jurkat cell lysate 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Rind (Kuh) Kaninchen Unkonjugiert WB Host:  Rabbit  Target Name:  Tbx5  Sample Type:  Mouse Pancreas lysates  Antibody Dilution:  1.0ug/ml 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p), WB Immunohistochemistry-Paraffin: TBX5 Antibody  - Staining of human lung shows moderate nuclear positivity in a subset of pneumocytes. Immunohistochemistry-Paraffin: TBX5 Antibody  - Staining of human heart muscle shows strong nuclear positivity in cardiomyocytes. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-TBX5 Antibody   Titration: 5 ug/ml   Positive Control: HepG2 Whole Cell 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
Human Kaninchen Unkonjugiert EIA, WB TBX5 Antibody (N-term) western blot analysis in CEM cell line lysates (35ug/lane).This demonstrates the TBX5 antibody detected the TBX5 protein (arrow). 0.4 mL Anmelden zum Anzeigen 6 bis 8 Tage
Fledermaus Kaninchen Unkonjugiert IHC, IHC (p), WB Human Brain, Cortex (formalin-fixed, paraffin-embedded) stained with TBX5 antibody ABIN462189 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. Human Breast (formalin-fixed, paraffin-embedded) stained with TBX5 antibody ABIN462189 followed by biotinylated goat anti-rabbit IgG secondary antibody ABIN481713, alkaline phosphatase-streptavidin and chromogen. 50 μg Anmelden zum Anzeigen 11 bis 14 Tage
Human Maus Unkonjugiert WB Western Blot analysis of TBX5 expression in transfected 293T cell line by TBX5 monoclonal antibody (M01), clone 1G10. Lane 1: TBX5 transfected lysate(57.7 KDa). Lane 2: Non-transfected lysate. Western blot analysis of TBX5 over-expressed 293 cell line, cotransfected with TBX5 Validated Chimera RNAi used as specificity and loading control. 100 μg Anmelden zum Anzeigen 8 bis 11 Tage
Human Maus Unkonjugiert ELISA, WB Figure 1: Western blot analysis using TBX5 mouse mAb against HepG2 cell lysate (1). Dilution: 1/500 - 1/2000 Figure 2: Confocal immunofluorescence analysis of HEK293 cells trasfected with extracellular ERBB3 (aa22-369)-hIgGFc using anti-ERBB3 monoclonal antioby (green). Blue: DRAQ5 fluorescent DNA dye. Dilution: 1:200~1000. 100 μL Anmelden zum Anzeigen 10 bis 11 Tage
Fledermaus Kaninchen Unkonjugiert WB 100 μg Anmelden zum Anzeigen 7 bis 9 Tage

TBX5 Antikörper nach Reaktivität, Anwendung, Klonalität and Konjugat

Attribute Applikationen Wirt Klonalität Konjugat
Human , , ,
, , , , ,
Mouse (Murine) , ,

Rat (Rattus) , ,

Am meisten referenzierte anti-T-Box 5 Antikörper

  1. Human Monoclonal TBX5 Primary Antibody für RNAi, ELISA - ABIN563098 : Ghosh, Song, Packham, Buxton, Robinson, Ronksley, Self, Bonser, Brook: Physical interaction between TBX5 and MEF2C is required for early heart development. in Molecular and cellular biology 2009 (PubMed)
    Show all 3 Pubmed References

  2. Cow (Bovine) Polyclonal TBX5 Primary Antibody für IHC, WB - ABIN2777915 : Zaragoza, Lewis, Sun, Wang, Li, Said-Salman, Feucht, Huang: Identification of the TBX5 transactivating domain and the nuclear localization signal. in Gene 2004 (PubMed)
    Show all 4 Pubmed References

  3. Human Polyclonal TBX5 Primary Antibody für ICC, IF - ABIN4358060 : Lian, Zhang, Azarin, Zhu, Hazeltine, Bao, Hsiao, Kamp, Palecek: Directed cardiomyocyte differentiation from human pluripotent stem cells by modulating Wnt/β-catenin signaling under fully defined conditions. in Nature protocols 2012 (PubMed)
    Show all 2 Pubmed References

  4. Human Monoclonal TBX5 Primary Antibody für ELISA, WB - ABIN969432 : Collavoli, Hatcher, He, Okin, Deo, Basson: TBX5 nuclear localization is mediated by dual cooperative intramolecular signals. in Journal of molecular and cellular cardiology 2003 (PubMed)

  5. Human Polyclonal TBX5 Primary Antibody für IHC (p), WB - ABIN658694 : Baban, Pitto, Pulignani, Cresci, Mariani, Gambacciani, Digilio, Pongiglione, Albanese: Holt-Oram syndrome with intermediate atrioventricular canal defect, and aortic coarctation: functional characterization of a de novo TBX5 mutation. in American journal of medical genetics. Part A 2014 (PubMed)

Weitere Antikörper gegen T-Box 5 Interaktionspartner

Xenopus laevis T-Box 5 (TBX5) Interaktionspartner

  1. we show TBX5 and TBX20 (zeige TBX20 Antikörper) can physically interact and map the interaction domains, and we show a cellular interaction for the two proteins in cardiac development

Human T-Box 5 (TBX5) Interaktionspartner

  1. TBX5 overexpression markedly suppressed in vitro NSCLC cell proliferation, colony formation, and invasion and induced apoptosis.

  2. TBX5 variants show possible pathogenic Fibrosis of the Cardiac Conduction system.

  3. TBX5 deficiency-mediated downregulation of NFAT3 (zeige NFATC4 Antikörper) is crucial for the high cytokine-producing activity of T cells

  4. A novel heterozygous missense mutation in TBX5 gene identified in a case of ventricular septal defect. The mutation causes significant changes of the activity of TBX5 in vitro.

  5. There is no difference in NKX2.5 (zeige NKX2-5 Antikörper) and TBX5 gene mutations between in vitro fertilization and naturally conceived children with congenital heart disease (CHD (zeige CHDH Antikörper)).

  6. Rs7312625 of TBx5 gene was significantly associated with lone atrial fibrillation, and snp-snp interaction increased the risk of atrial fibrillation.

  7. Hence, the variant distribution of NKX2-5 (zeige NKX2-5 Antikörper), GATA4 (zeige GATA4 Antikörper) and TBX5 are tightly associated with particular Congenital heart disease subtypes. Further structure-modelling analysis revealed that these mutated amino acid residuals maintain their DNA-binding ability and structural stability

  8. Findings suggest that a single introduction of the three cardiomyogenic transcription factor (GATA4 (zeige GATA4 Antikörper), cand TBX5)genes using polyethyleneimine (PEI)-based transfection is sufficient for transdifferentiation of adipose-derived stem cells (hADSCs) towards the cardiomyogenic lineage.

  9. Three genes-ATP6V1G1 (zeige ATP6V1G1 Antikörper) in 9q32, GMPS (zeige GMPS Antikörper) in 3q25.31, and TBX5 in 12q24.21-exhibited concomitant hypermethylation and decreased expression. The i(12p)-positive cells displayed global hypomethylation of gene-poor regions on 12p, a footprint previously associated with constitutional and acquired gains of whole chromosomes as well as with X-chromosome inactivation in females

  10. report on the association between a TBX5 lossoffunction mutation and increased susceptibility to atrial fibrillation

Mouse (Murine) T-Box 5 (TBX5) Interaktionspartner

  1. Enrichment of induced cardiomyocytes derived from mouse fibroblasts can be achieved by reprogramming with cardiac transcription factors, Gata4 (zeige GATA4 Antikörper), MEF2c (zeige MEF2C Antikörper), Tbx5, and Hand2 (zeige HAND2 Antikörper).

  2. Defined a transcriptional architecture for atrial rhythm control organized as an incoherent feed-forward loop, driven by TBX5 and modulated by PITX2 (zeige PITX2 Antikörper). TBX5/PITX2 (zeige PITX2 Antikörper) interplay provides tight control of atrial rhythm effector gene expression, and perturbation of the co-regulated network caused atrial fibrillation susceptibility.

  3. The data also suggest that, in human, KLF13 (zeige KLF13 Antikörper) may be a genetic modifier of the Holt-Oram Syndrome gene TBX5.

  4. Our data demonstrate an early, inherent asymmetry in the left and right limb-forming regions and that threshold levels of Tbx5 are required to overcome this asymmetry to ensure symmetric forelimb formation.

  5. Data show that three transcriptional factors Gata4 (zeige GATA4 Antikörper), Mef2c (zeige MEF2C Antikörper), and Tbx5 (abbreviated as GMT (zeige GAMT Antikörper)) significantly improved murine embryonic stem cells (ESCs (zeige NR2E3 Antikörper)) differentiated into cardiomyocytes.

  6. defines a TBX5-nucleosome remodeling and deacetylase interaction essential to cardiac development and the evolution of the mammalian heart

  7. Study reports extensive and complex interdependent genomic occupancy of TBX5, NKX2-5 (zeige NKX2-5 Antikörper), and the zinc finger TF GATA4 (zeige GATA4 Antikörper) coordinately controlling cardiac gene expression, differentiation, and morphogenesis.

  8. Tbx5 and Osr1 (zeige OSR1 Antikörper) interact to regulate posterior second heart field cell cycle progression for cardiac septation.

  9. Haploinsufficiency of Tbx5 and trisomy affects alignment of the aorta and this effect may stem from deviations from normal left-right patterning in the heart; study unveiled a previously unknown interaction between the Tbx5 gene and trisomy, suggesting a connection between Tbx5 and trisomic genes important during heart development.

  10. These findings elucidate mechanisms regulating the commitment of mesodermal cells in the early embryo and identify the Tbx5 cardiac transcriptome.

Zebrafish T-Box 5 (TBX5) Interaktionspartner

  1. Regulatory evolution of Tbx5 and the origin of paired appendages, such as fins, is presented.

  2. a mesodermal Fgf24 convergence cue controlled by Tbx5a underlies this asymmetric convergent motility.

  3. Results show that cul4a (zeige CUL4A Antikörper) but not cul4b (zeige CUL4B Antikörper) is required for the expression of tbx5a, an essential transcription factor in heart and limb development.

  4. The tbx5 genes have essential roles in the establishment of cardiac laterality, dorsoventral retina axis organization and pectoral fin development.

  5. tbx5 knockdown causes a pseudo GH deficiency in zebrafish during early embryonic stages, and supplementation of exogenous GH can partially restore dysmorphogenesis, apoptosis, cell growth inhibition, and abnormal cardiomyogenesis

  6. tbx5 deficiency evoked apoptosis, distributed on multiple organs corresponding to dysmorphogenesis with the shortage of promising maturation, in tbx5 knockdown zebrafish embryos

  7. data demonstrate that elevated glucose alone induces cardiac defects in zebrafish embryos by altering the expression pattern of tbx5, tbx20 (zeige TBX20 Antikörper), and has2 (zeige HAS2 Antikörper) in the heart

  8. Tbx5a confers anterior lateral plate mesodermal cells the competence to respond to Bmp signals and initiate proepicardial organ development.

  9. Pdlim7 (zeige PDLIM7 Antikörper)/Tbx5 interactions affect the expression of Tbx5 target genes nppa (zeige NPPA Antikörper) and tbx2b at the atrio-ventricular boundary, and their domains of misexpression directly correlate with the identified valve defects.

  10. The heartstrings mutation in zebrafish causes heart/fin Tbx5 deficiency syndrome.

T-Box 5 (TBX5) Antigen-Profil

Protein Überblick

This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in this gene have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for this gene.

Genbezeichner und Symbole assoziert mit anti-T-Box 5 (TBX5) Antikörper

  • T-box 5 (TBX5) Antikörper
  • T-box 5 (tbx5) Antikörper
  • T-box 5 L homeolog (tbx5.L) Antikörper
  • T-box 5 (Tbx5) Antikörper
  • T-box 5a (tbx5a) Antikörper
  • HOS Antikörper
  • tbx-5 Antikörper
  • tbx5 Antikörper
  • tbx5.1 Antikörper
  • xtbx-5 Antikörper
  • xtbx5 Antikörper
  • zf-tbx5 Antikörper
  • zTbx5 Antikörper

Bezeichner auf Proteinebene für anti-T-Box 5 (TBX5) Antikörper

T-box 5 , T-box protein 5 , T-box transcription factor 5 , T-box transcription factor TBX5 , T-box transcription factor TBX5-like , t-box transcription factor TBX5-like , T-box gene 5 , T-box gene 5.1 , T-box transcription factor TBX5-A , etID310031.5 , heartstrings , hst , zftbx5a

452276 Pan troglodytes
619589 Xenopus (Silurana) tropicalis
713550 Macaca mulatta
100018880 Monodelphis domestica
100356836 Oryctolagus cuniculus
100397050 Callithrix jacchus
100451005 Pongo abelii
100478001 Ailuropoda melanoleuca
100529166 Oryzias latipes
373738 Xenopus laevis
373988 Gallus gallus
6910 Homo sapiens
491447 Canis lupus familiaris
21388 Mus musculus
304514 Rattus norvegicus
532970 Bos taurus
30071 Danio rerio
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