T-Box 5 (TBX5) (N-Term) Antikörper

Details zu Produkt Nr. ABIN2777915, Anbieter: Anmelden zum Anzeigen
Antigen
  • TBX5
  • tbx-5
  • xtbx-5
  • xtbx5
  • tbx5
  • HOS
  • tbx5.1
  • zTbx5
  • zf-tbx5
  • T-box 5
  • T-box 5 L homeolog
  • T-box 5a
  • TBX5
  • tbx5
  • tbx5.L
  • Tbx5
  • tbx5a
Epitop
N-Term
18
14
9
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Rind (Kuh), Hund, Ziege, Meerschweinchen, Pferd, Human, Maus, Kaninchen, Ratte (Rattus), Schaf, Zebrafisch (Danio rerio)
73
19
15
9
6
6
6
5
5
5
3
3
3
3
3
2
2
Wirt
Kaninchen
48
25
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
3
3
3
3
3
3
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
68
46
23
5
4
3
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen The immunogen is a synthetic peptide directed towards the N terminal region of human TBX5
Blocking Peptide Zu diesem Produkt passt das Blocking Peptide ABIN984848.
Sequenz NSMHKYQPRL HIVKADENNG FGSKNTAFCT HVFPETAFIA VTSYQNHKIT
Homologie Cow: 100%, Dog: 100%, Goat: 100%, Guinea Pig: 100%, Horse: 100%, Human: 100%, Mouse: 100%, Rabbit: 100%, Rat: 100%, Sheep: 100%, Zebrafish: 100%
Produktmerkmale This is a rabbit polyclonal antibody against TBX5. It was validated on Western Blot using a cell lysate as a positive control.
Reinigung Affinity Purified
Andere Bezeichnung TBX5 (TBX5 Antibody Abstract)
Hintergrund TBX5 is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. TBX5 is closely linked to related family member T-box 3 (ulnar mammary syndrome) on human chromosome 12. The encoded protein may play a role in heart development and specification of limb identity. Mutations in TBX5 have been associated with Holt-Oram syndrome, a developmental disorder affecting the heart and upper limbs. Several transcript variants encoding different isoforms have been described for TBX5.
Alias Symbols: HOS
Protein Interaction Partner: KDM6A, SMARCA4, KAT5, GATA4, NKX2-5,
Protein Size: 518
Molekulargewicht 58 kDa
Gen-ID 6910
NCBI Accession NM_000192, NP_000183
UniProt Q99593
Applikationshinweise Optimal working dilutions should be determined experimentally by the investigator.
Kommentare

Antigen size: 518 AA

Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration Lot specific
Buffer Liquid. Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freeze-thaw cycles.
Lagerung -20 °C
Informationen zur Lagerung For short term use, store at 2-8°C up to 1 week. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Bilder des Herstellers
Western Blotting (WB) image for anti-T-Box 5 (TBX5) (N-Term) antibody (ABIN2777915) WB Suggested Anti-TBX5 Antibody Titration: 0.2-1 ug/ml
ELISA Titer: ...
Immunohistochemistry (IHC) image for anti-T-Box 5 (TBX5) (N-Term) antibody (ABIN2777915) anti-T-Box 5 (TBX5) (N-Term) antibody (Image 2)
Produkt verwendet in: Baban, Pitto, Pulignani, Cresci, Mariani, Gambacciani, Digilio, Pongiglione, Albanese: "Holt-Oram syndrome with intermediate atrioventricular canal defect, and aortic coarctation: functional characterization of a de novo TBX5 mutation." in: American journal of medical genetics. Part A, Vol. 164A, Issue 6, pp. 1419-24, 2014 (PubMed).

Zhang, Huang, Zuo, Chen, Wang: "Phenanthrene exposure causes cardiac arrhythmia in embryonic zebrafish via perturbing calcium handling." in: Aquatic toxicology (Amsterdam, Netherlands), Vol. 142-143, pp. 26-32, 2013 (PubMed).

Lu, Tsai, Choo, Yeh, Tang, Yang, Lee, Lu: "Induction of apoptosis and inhibition of cell growth by tbx5 knockdown contribute to dysmorphogenesis in Zebrafish embryos." in: Journal of biomedical science, Vol. 18, pp. 73, 2011 (PubMed).

Allgemeine Veröffentlichungen Zaragoza, Lewis, Sun, Wang, Li, Said-Salman, Feucht, Huang: "Identification of the TBX5 transactivating domain and the nuclear localization signal." in: Gene, Vol. 330, pp. 9-18, 2004 (PubMed).

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