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The protein encoded by SNCB is highly homologous to alpha-synuclein. Zusätzlich bieten wir Ihnen beta Synuclein Proteine (16) und beta Synuclein Kits (10) und viele weitere Produktgruppen zu diesem Protein an.
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Cells that overexpress alpha-syn showed increased susceptibility to the toxicity of the oligomers, while those that overexpressed beta-syn (zeige FYN Antikörper) showed increased resistance to the toxic oligomers.
alterations in the plasma alpha-synuclein and beta-synuclein levels might be implicated in the association between synaptic abnormalities and autism spectrum disorder pathogenesis.
Study suggests that beta-synuclein changes in Dementia with Lewy bodies may exacerbate neuronal dysfunction caused by accumulation of alpha-synuclein by influencing protein degradation.
Data suggest that pH serves as an on/off switch for beta- synuclein to form aggregates/fibrils (as seem in Parkinson disease); hydrogen bonding between glutamate (zeige GRIN1 Antikörper) residues appears to be involved in fibril formation.
loss of inhibitory C-terminal conformations in disease associated P123H beta-synuclein
beta-Synuclein expression was locally concentrated and rather modest, but nevertheless changed its effect on amyloid precursor protein (zeige APP Antikörper) expression and plaque load in a time- and concentration-dependent manner.
The differing aggregation propensities of alpha-synuclein and beta-synuclein are associated with differences in the degree of residual structure in the C-terminus coupled to the shorter separation between the N- and C-termini in beta-synuclein.
Beta-synuclein protects against isoaspartate accumulation in alpha-synuclein.
In vivo cross-linking reveals principally oligomeric forms of alpha-synuclein and beta-synuclein in neurons and non-neural cells
Thermodynamic studies in conjunction with EPR confirm that alpha-synuclein, beta-synuclein, and gamma-synuclein bind copper(II) in a high affinity 1:1 stoichiometry.
the expression patterns of neuronal maturation markers in the brain of a mouse model of dementia with Lewy body-linked mutant beta-synuclein (betaS), especially in the hippocampus.
Immunoblot analysis of beta-synuclein and Akt (zeige AKT1 Antikörper) levels in the mice reveals selective increases in beta-synuclein and phosphorylated Akt (zeige AKT1 Antikörper) levels in ventral midbrain
Beta-synuclein decreased formation of Lewy bodies by 40%, and prevented functional deficits associated with overexpression of alpha-synuclein. This is a preliminary in vivo proof of antiaggregatory function of beta-synuclein.
Accelerated accumulation of beta-synuclein is found in axonal spheroids of gracile axonal dystrophy mice, which do not express ubiquitin carboxyl-terminal hydrolase L1.
beta-synuclein knockout mice show that synucleins are not essential components of the basic machinery for neurotransmitter release but may contribute to the long-term regulation and/or maintenance of presynaptic function.
Developmentally, gamma-synuclein (zeige SNCG Antikörper) can be seen in the region of the outer hair cells by E19, while alpha- and beta-synuclein do not clearly appear there until approximately P10 (zeige NUTF2 Antikörper)
Data show the sequences of zebrafish synucleins are very similar to those of the human proteins. Whole-mount in situ hybridization show that sncb were expressed strongly in the nervous system.
The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease\; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene.
, PNP 14
, phosphoneuroprotein 14
, synuclein, beta
, putative beta-synuclein variant 1