Succinate-CoA Ligase, ADP-Forming, beta Subunit Proteine (SUCLA2)

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. Zusätzlich bieten wir Ihnen SUCLA2 Antikörper (26) und und viele weitere Produktgruppen zu diesem Protein an.

alle Proteine anzeigen Gen GeneID UniProt
SUCLA2 20916 Q9Z2I9
SUCLA2 8803 Q9P2R7
SUCLA2 511090 Q148D5
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Top SUCLA2 Proteine auf antikoerper-online.de

Showing 8 out of 8 products:

Katalog Nr. Origin Quelle Konjugat Bilder Menge Anbieter Lieferzeit Preis Details
Insektenzellen Human His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
Insektenzellen Maus His tag „Crystallography Grade“ protein due to multi-step, protein-specific purification process 1 mg Anmelden zum Anzeigen 50 Days
$6,869.04
Details
HEK-293 Cells Human Myc-DYKDDDDK Tag Validation with Western Blot 20 μg Anmelden zum Anzeigen Verfügbar
$814.00
Details
Wheat germ Human GST tag 10 μg Anmelden zum Anzeigen 11 bis 12 Tage
$414.29
Details
Hefe Syrischer Goldhamster His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$2,552.00
Details
Hefe Cynomolgus His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,142.33
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Hefe Rind (Kuh) His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,142.33
Details
Hefe Wildschwein His tag   1 mg Anmelden zum Anzeigen 60 bis 71 Tage
$3,142.33
Details

SUCLA2 Proteine nach Spezies und Herkunft

Origin Exprimiert in Konjugat
Mouse (Murine)

Human , ,
, ,
Cow (Bovine)

Weitere Proteine zu Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2) Interaktionspartnern

Mouse (Murine) Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2) Interaktionspartner

  1. Sucla2(SAbetageo) homozygotes exhibited recessive lethality, with most mutants dying late in gestation (e18.5). Mutant placenta and embryonic (e17.5) brain, heart and muscle showed varying degrees of mitochondrial DNA depletion.

  2. ADP and GDP succinyl-CoA (zeige OXCT1 Proteine) synthetases have different expression patterns and specificity

Human Succinate-CoA Ligase, ADP-Forming, beta Subunit (SUCLA2) Interaktionspartner

  1. SUCLA2 mutation is associated with Down syndrome and mitochondrial depletion syndrome.

  2. The patient's cells lack the SUCLG1 (zeige SUCLG1 Proteine) protein, with significantly reduced levels of SUCLA2 and SUCLG2 (zeige SUCLG2 Proteine) protein

  3. Sucla2 is related to the developmental stages of mouse spermatogenesis. Knockdown of Sucla2 decreases the viability of mouse spermatocytes by inducing apoptosis via decreased mitochondrial function of the cells.

  4. Long survival, to age 20 years or older, was reported in 12% of SUCLA2 and in 10% of SUCLG1 (zeige SUCLG1 Proteine) patients.

  5. XDH (zeige XDH Proteine) and SUCLA2 genes associated with thiopurine-induced leukopenia can act in a complex interactive manner in patients with Crohn's disease.

  6. The absence of SUCLA2 and SUCLG2 (zeige SUCLG2 Proteine) in human glia is in compliance with the presence of alternative pathways occurring in these cells, namely the GABA shunt and ketone body metabolism

  7. SUCLA2 mutations should be analyzed in patients with slowly progressive encephalomyopathy, even in the absence of methylmalonic aciduria or mitochondrial DNA depletion.

  8. This study demonstrated that SUCLA2 is expressed exclusively in neurons in the human cerebral cortex.

  9. Identification of a novel mutation in SUCLA2 in two cousins affected with encephalomyopathy, is reported.

  10. A novel homozygous mutation in SUCLA2 gene has been associated with severe mitochondrial encephalomyopathies in two Italian siblings.

SUCLA2 Protein Überblick

Protein Überblick

Succinyl-CoA synthetase (SCS) is a mitochondrial matrix enzyme that acts as a heterodimer, being composed of an invariant alpha subunit and a substrate-specific beta subunit. The protein encoded by this gene is an ATP-specific SCS beta subunit that dimerizes with the SCS alpha subunit to form SCS-A, an essential component of the tricarboxylic acid cycle. SCS-A hydrolyzes ATP to convert succinate to succinyl-CoA. Defects in this gene are a cause of myopathic mitochondrial DNA depletion syndrome. A pseudogene of this gene has been found on chromosome 6.

Genbezeichner und Symbole assoziert mit SUCLA2

  • succinate-Coenzyme A ligase, ADP-forming, beta subunit (Sucla2)
  • succinate-CoA ligase ADP-forming beta subunit (SUCLA2)
  • 4930547K18Rik Protein
  • A-BETA Protein
  • MTDPS5 Protein
  • SCS Protein
  • SCS-betaA Protein

Bezeichner auf Proteinebene für SUCLA2

ATP-specific succinyl-CoA synthetase subunit beta , SCS-betaA , succinyl-CoA ligase [ADP-forming] subunit beta, mitochondrial , succinyl-CoA synthetase beta-A chain , ATP-specific succinyl-CoA synthetase, beta subunit , mitochondrial succinyl-CoA ligase [ADP-forming] subunit beta , renal carcinoma antigen NY-REN-39 , ATP-specific succinyl-CoA synthetase beta , Succinyl-CoA ligase [ADP-forming] beta-chain, mitochondrial

GENE ID SPEZIES
20916 Mus musculus
8803 Homo sapiens
511090 Bos taurus
485448 Canis lupus familiaris
399540 Sus scrofa
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