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SLC12A1 encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. Zusätzlich bieten wir Ihnen SLC12A1 Kits (11) und SLC12A1 Proteine (10) und viele weitere Produktgruppen zu diesem Protein an.
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Human Polyclonal SLC12A1 Primary Antibody für IHC, WB - ABIN863200
Caceres, Ares, Ortiz: cAMP stimulates apical exocytosis of the renal Na(+)-K(+)-2Cl(-) cotransporter NKCC2 in the thick ascending limb: role of protein kinase A. in The Journal of biological chemistry 2009
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Cow (Bovine) Polyclonal SLC12A1 Primary Antibody für IHC, WB - ABIN2776780
Kelsen, Patel, Parker, Vera, Rimoldi, Gadepalli, Drummond, Stec: Heme oxygenase attenuates angiotensin II-mediated superoxide production in cultured mouse thick ascending loop of Henle cells. in American journal of physiology. Renal physiology 2008
Show all 3 Pubmed References
Human Polyclonal SLC12A1 Primary Antibody für IHC, IHC (p) - ABIN4339832
Schrödter, Braun, Syring, Klümper, Deng, Schmidt, Perner, Müller, Ellinger: Identification of the dopamine transporter SLC6A3 as a biomarker for patients with renal cell carcinoma. in Molecular cancer 2016
Human Polyclonal SLC12A1 Primary Antibody für IHC, IHC (p) - ABIN4891581
Toka, Al-Romaih, Koshy, DiBartolo, Kos, Quinn, Curhan, Mount, Brown, Pollak: Deficiency of the calcium-sensing receptor in the kidney causes parathyroid hormone-independent hypocalciuria. in Journal of the American Society of Nephrology : JASN 2012
an association between primary hyperparathyroidism and loss of function mutation of SLC12A1, which may result in an aberrant threshold of the calcium sensing receptor (zeige CASR Antikörper) at the level of the kidney, is reported.
A novel variant in the SLC12A1 gene, c.1614T>A, which predicts a change from a tyrosine codon to a stop codon (p.Tyr538Ter) was found in two families with Bartter syndrome type I.
Low SLC12A1 urine levels were associated with Bartter syndrome.
Mutations in SLC12A1 gene is associated with Bartter syndrome.
Urinary NKCC2 increased in chronic kidney disease patients and decreased in controls in response to hypertonic saline.
The association between polymorphisms in KCNJ1 (zeige KCNJ1 Antikörper), SLC12A1, and 7 other genes and calcium intake and colorectal neoplasia risk was studied.
overexpression of mammalian plasma-membrane Na+-K+-2Cl- co-transporter NKCC2 in yeast cells complements the phenotypes resulting from the deletion of the VHC1 gene.
NKCC2 mutations result in impaired apical targeting and function of NKCC2 transporter and give rise to a pathological phenotype known as type I Bartter syndrome. (Review)
Data show that intracellular association between WNK1 (zeige WNK1 Antikörper) and oxidative stress-responsive 1 (OSR1 (zeige OXSR1 Antikörper)) is required for stimulation of OSR1 (zeige OXSR1 Antikörper) and Na(+), K(+), Cl(-)-Cotransporter NKCC1 (zeige SLC12A2 Antikörper) and NKCC2 activities by osmotic stress.
NKCC1 (zeige SLC12A2 Antikörper) and NKCC2 were expressed in the gastric mucosa of rat, mouse and human.
SLC12A1 (g.62382825G>A, p.Pro372Leu) is a hypomorphic or loss-of-function mutation and the hydrallantois with this mutation shows incomplete penetrance in Japanese Black cattle.
The differential regulation of ROMK (zeige KCNJ1 Antikörper), large-conductance Ca(2 (zeige CA2 Antikörper)+)-activated K(+) (BK) channel (zeige KCNMA1 Antikörper), BK-alpha and NKCC2 between female and male mice, at least, were partly mediated via WNK1 (zeige WNK1 Antikörper) pathway, which may contribute to the sexual dimorphism of plasma K(+) and blood pressure control.
VAMP3 (zeige VAMP3 Antikörper) is required for normal NKCC2 expression, renal function, and blood pressure.
IL-1 (zeige IL1A Antikörper) receptor (IL-1R1) deficiency or blockade limits blood pressure elevation in this model by mitigating sodium reabsorption via the NKCC2 co-transporter in the nephron.
Data suggest renal cell lines exhibit an OS9- (osteosarcoma amplified 9 protein-)mediated ERAD (endoplasmic reticulum-associated degradation) pathway that degrades Nkcc2/Slc12a1 prior to glycosylation/processing.
The findings demonstrated a substantial role of mitochondrial dysfunction in mediating the downregulation of NKCC2 and ENaCalpha (zeige SCNN1A Antikörper) in obstructive kidney disease, possibly via iNOS (zeige NOS2 Antikörper)-derived nitric oxide and BNP (zeige BNC2 Antikörper).
our results suggest that NKCCs are involved in insulin (zeige INS Antikörper) secretion and that a single Slc12a2 (zeige SLC12A2 Antikörper) allele may protect beta-cells from failure due to increased homeostatic expression of Slc12a1.
Vasopressin (zeige AVP Antikörper) plays an important role in the colonic epithelia by stimulating NKCC2 trafficking to the apical membrane and inducing NKCC2-mediated ion transport.
In this systemic analysis no clear primary effects of the Slc12a1I299F mutation appeared for the organs other than the kidneys where Slc12a1 expression has been described.
increased phosphorylation of Na(+)-K(+)-2Cl(-) cotransporter in obesity and identifies a new role for AMP-activated protein kinase in regulating the activity of oxidative stress responsive 1 kinase-related proline-alanine-rich protein kinase
Differential splicing of NKCC2 contributes to the adaptive capacity of the kidney to cope with changes in reabsorptive needs.
This gene encodes a kidney-specific sodium-potassium-chloride cotransporter that is expressed on the luminal membrane of renal epithelial cells of the thick ascending limb of Henle's loop and the macula densa. It plays a key role in concentrating urine and accounts for most of the NaCl resorption. It is sensitive to such diuretics as furosemide and bumetanide. Some Bartter-like syndromes result from defects in this gene. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional splice variants have been described but their biological validity in humans has not been experimentally proven.
FERM domain-containing protein 4A
, Na/K/Cl cotransporter
, solute carrier family 12 (sodium/potassium/chloride transporters), member 1
, solute carrier family 12 member 1-like
, NKCC2A variant A
, Na-K-2Cl cotransporter
, bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2
, kidney-specific Na-K-Cl symporter
, solute carrier family 12 member 1
, Solute carrier family 12 member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter)
, Solute carrier family 12, member 1 (bumetanide-sensitive sodium-[potassium]-chloride cotransporter)
, apical Na(2Cl)K cotransporter
, solute carrier family 12, member 1
, bumetanide-sensitive cotransporter type 1