anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6) Antikörper

SLC12A6 is a member of the K-Cl cotransporter (KCC) family. Zusätzlich bieten wir Ihnen Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 Proteine (9) und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SLC12A6 691209  
SLC12A6 9990 Q9UHW9
SLC12A6 107723 Q924N4
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Top anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 Antikörper auf antikoerper-online.de

Showing 10 out of 75 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Human Ziege Unkonjugiert IHC, ELISA, WB ABIN238578 (0.1µg/ml) staining of Human Heart lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
Details
Human Kaninchen Unkonjugiert IHC (p), WB SLC12A6 Antibody (N-term) (ABIN656316) immunohistochemistry analysis in formalin fixed and paraffin embedded human kidney tissue followed by peroxidase conjugation of the secondary antibody and DAB staining. 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Ziege Unkonjugiert IHC (p), IHC, ELISA, WB Immunohistochemistry-Paraffin: KCC3/SLC12A6 Antibody [NBP1-06044] - (2.5ug/ml) staining of paraffin embedded Human Heart. Steamed antigen retrieval with citrate buffer pH 6, AP-staining. Western Blot: KCC3/SLC12A6 Antibody [NBP1-06044] - (0.1ug/ml) staining of Human Heart lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence. 0.1 mg Anmelden zum Anzeigen 7 bis 9 Tage
$488.73
Details
Human Ziege Unkonjugiert ELISA, WB 100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$610.50
Details
Human Kaninchen Unkonjugiert WB Anti-SLC12A6 antibody, Western blotting Lane 1: HELA Cell Lysate Lane 2: HUT102 Cell Lysate 100 μg Anmelden zum Anzeigen 4 bis 6 Tage
$240.00
Details
Human Maus Unkonjugiert ELISA, WB Western Blot detection against Immunogen (36.01 KDa) . 50 μL Anmelden zum Anzeigen 11 bis 12 Tage
$305.71
Details
Human Ziege Biotin ELISA, IHC, WB   100 μg Anmelden zum Anzeigen 6 bis 7 Tage
$429.84
Details
Human Kaninchen Unkonjugiert ICC, IF, IHC, IHC (p) Immunohistochemistry: KCC3/SLC12A6 Antibody [NBP1-89282] - Staining of human pancreas shows strong cytoplasmic positivity in exocrine pancreas. Immunocytochemistry/Immunofluorescence: KCC3/SLC12A6 Antibody [NBP1-89282] - Human cell line A-431 shows positivity in cytoplasm & vesicles. Antibody staining is shown in green. 0.1 mL Anmelden zum Anzeigen 10 bis 13 Tage
$494.38
Details
Rind (Kuh) Kaninchen Unkonjugiert WB   100 μg Anmelden zum Anzeigen 11 bis 14 Tage
$463.83
Details
Human Ziege PE IHC, ELISA, WB   100 μL Anmelden zum Anzeigen 16 Days
$760.57
Details

Am meisten referenzierte anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 Antikörper

  1. Human Polyclonal SLC12A6 Primary Antibody für ELISA, WB - ABIN564298 : Salin-Cantegrel, Shekarabi, Holbert, Dion, Rochefort, Laganière, Dacal, Hince, Karemera, Gaspar, Lapointe, Rouleau: HMSN/ACC truncation mutations disrupt brain-type creatine kinase-dependant activation of K+/Cl- co-transporter 3. in Human molecular genetics 2008 (PubMed)
    Show all 4 Pubmed References

  2. Human Polyclonal SLC12A6 Primary Antibody für ELISA, WB - ABIN548017 : Simard, Bergeron, Frenette-Cotton, Carpentier, Pelchat, Caron, Isenring: Homooligomeric and heterooligomeric associations between K+-Cl- cotransporter isoforms and between K+-Cl- and Na+-K+-Cl- cotransporters. in The Journal of biological chemistry 2007 (PubMed)

  3. Human Polyclonal SLC12A6 Primary Antibody für ICC, IF - ABIN4328465 : Shiozaki, Takemoto, Ichikawa, Fujiwara, Konishi, Kosuga, Komatsu, Okamoto, Kishimoto, Marunaka, Otsuji: The K-Cl cotransporter KCC3 as an independent prognostic factor in human esophageal squamous cell carcinoma. in BioMed research international 2014 (PubMed)

Weitere Antikörper gegen Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 Interaktionspartner

Human Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6) Interaktionspartner

  1. Neurodegenerative deficits in hereditary motor and sensory neuropathy associated with agenesis of the corpus callosum are primarily caused by an axonopathy superimposed upon abnormal development, affecting peripheral but also central nervous system axons, all ultimately because of a genetic defect in the axonal cotransporter KCC3.

  2. These results suggest that the function of the peripheral nervous system depends on finely tuned, kinase-regulated KCC3 activity and implicate abnormal cell volume homeostasis as a previously unreported mechanism of axonal degeneration.

  3. These results suggest that the expression of KCC3 in ESCC may affect cellular invasion and be related to a worse prognosis in patients with ESCC.

  4. SPAK may promote KCC3-mediated cervix tumor aggressiveness via the NF-kappaB/p38 MAPK/MMP2 axis.

  5. SLC12A6 has been shown to be causative in Andermann Syndrome.

  6. serine residue 96 of human KCC3 is a third site that has to be dephosphorylated for full activation of the cotransporter during hypotonicity.

  7. mis-trafficking of mutant protein is an important pathophysiological feature of HMSN/ACC causative KCC3 mutations.

  8. Neuropathic features of hereditary motor and sensory neuropathy/agenesis of corpus callosum in transgenic mouse lines are predominantly due to a neuronal KCC3 deficit, while the auditory impairment is due to loss of non-neuronal KCC3 expression.

  9. The Wnk3 protein isoforms have a similar effect on SLC12 cotransporters. NKCC1/2 and NCC were inhibited, even in hypertonicity, while KCCs were activated, even in isotonic conditions.

  10. KCC3 is the dominant isoform in erythrocytes, with variable expression of KCC1 and KCC4 that could result in modulation of KCC activity

  11. mutations of the KCC3 gene may result in non-syndromic childhood onset of demyelinating hereditary motor and sensory neuropathy

  12. human osteoblasts express functional K-Cl cotransporters in their cell membrane that seem to be able to induce the indirect activation of volume-sensitive Cl- channels by KCl through an increase in the intracellular ions, water influx and cell swelling.

  13. all of the CCCs examined (NKCC1, NKCC2, KCC1, KCC3, and KCC4) can promote NH4(+) translocation, presumably through binding of the ion at the K(+) site

  14. KCC activation by IGF-1 plays an important role in IGF-1 signaling to promote growth and spread of gynecological cancers.

  15. Not only truncating but also missense mutations of the KCC3 gene are associated with Andermann syndrome.

  16. Among patients with early-stage node-negative breast cancer, disease-free survival (DFS) and overall survival (OS) curves were significantly different based on IGF-1 and KCC expression.

  17. KCC3 mutations in exon 22 constitute a recurrent mutation site for hereditary motor and sensory neuropathy with agenesis of the corpus callosum (HMSN/ACC), regardless of ethnic origin.

  18. KCC3 down-regulates E-cadherin/beta-catenin complex formation by inhibiting transcription of E-cadherin gene and accelerating proteosome-dependent degradation of beta-catenin protein

  19. study provides evidence that the upstream SLC12A6 G/A promoter SNP is functional not only by changing the DNA primary structure but also by influencing the allelic epigenotype and consequently by influencing the chromatin organization

  20. Using a yeast 2-hybrid it was discovered that the C-terminal domain of KCC3, that is lost in most hereditary motor and sensory neuropathy with agenesis of the corpus callosum-causing mutations, directly interacts with brain-specific creatine kinase.

Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 6 (SLC12A6) Antigen-Profil

Protein Überblick

This gene is a member of the K-Cl cotransporter (KCC) family. K-Cl cotransporters are integral membrane proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The proteins encoded by this gene are activated by cell swelling induced by hypotonic conditions. Alternate splicing results in multiple transcript variants encoding different isoforms. Mutations in this gene are associated with agenesis of the corpus callosum with peripheral neuropathy.

Genbezeichner und Symbole assoziert mit SLC12A6

  • solute carrier family 12, member 6 (Slc12a6) Antikörper
  • solute carrier family 12 member 6 (SLC12A6) Antikörper
  • 9530023I19Rik Antikörper
  • ACCPN Antikörper
  • gaxp Antikörper
  • KCC3 Antikörper
  • KCC3A Antikörper
  • KCC3B Antikörper

Bezeichner auf Proteinebene für SLC12A6

solute carrier family 12 member 6 , furosemide-sensitive KCl cotransporter 3 , K-Cl cotransporter 3 , electroneutral potassium-chloride cotransporter 3 , potassium chloride cotransporter 3 , potassium chloride cotransporter KCC3a-S3 , potassium-chloride transporter-3a , potassium-chloride transporter-3b , solute carrier family 12 (potassium/chloride transporters), member 6

GENE ID SPEZIES
691209 Rattus norvegicus
9990 Homo sapiens
107723 Mus musculus
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