anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) Antikörper

K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. Zusätzlich bieten wir Ihnen Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 Proteine (8) und und viele weitere Produktgruppen zu diesem Protein an.

Alle Antikörper anzeigen Gen GeneID UniProt
SLC12A5 171373 Q63633
SLC12A5 57468 Q9H2X9
SLC12A5 57138 Q91V14
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Top anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 Antikörper auf antikoerper-online.de

Showing 10 out of 137 products:

Katalog Nr. Reaktivität Wirt Konjugat Applikation Bilder Menge Anbieter Lieferzeit Preis Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-SLC12A5 Antibody Titration:  0.2-1 ug/ml  Positive Control:  Human Spleen 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$289.00
Details
Rind (Kuh) Kaninchen Unkonjugiert WB WB Suggested Anti-Slc12a5 Antibody   Titration: 1.0 ug/ml   Positive Control: Mouse Brain 100 μL Anmelden zum Anzeigen 2 bis 3 Tage
$319.00
Details
Human Maus Unkonjugiert ICC, IF, IHC, IP, WB western rat membrane 1 in 1000 KCC2. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
$453.70
Details
Human Kaninchen Unkonjugiert IHC (p), WB SLC12A5 Antibody (N-term) (ABIN652057) western blot analysis in K562 cell line lysates (35 µg/lane). This demonstrates the SLC12A5 antibody detected the SLC12A5 protein (arrow). SLC12A5 Antibody (N-term) (ABIN652057) immunohistochemistry analysis in formalin fixed and paraffin embedded human brain tissue followed by peroxidase conjugation of the secondary antibody and DAB staining 400 μL Anmelden zum Anzeigen 10 bis 11 Tage
$385.00
Details
Human Maus HRP ICC, IF, IHC, IP, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-KCC2 Monoclonal Antibody, Clone S1-12 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-KCC2 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:200 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) KCC2 Antibody (D) Composite. Western Blot analysis of Rat brain membrane lysate showing detection of KCC2 protein using Mouse Anti-KCC2 Monoclonal Antibody, Clone S1-12 . Primary Antibody: Mouse Anti-KCC2 Monoclonal Antibody  at 1:1000. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
$499.20
Details
Human Maus FITC ICC, IF, IHC, IP, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-KCC2 Monoclonal Antibody, Clone S1-12 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-KCC2 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:200 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) KCC2 Antibody (D) Composite. Western Blot analysis of Rat brain membrane lysate showing detection of KCC2 protein using Mouse Anti-KCC2 Monoclonal Antibody, Clone S1-12 . Primary Antibody: Mouse Anti-KCC2 Monoclonal Antibody  at 1:1000. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
$504.40
Details
Human Maus Alkaline Phosphatase (AP) ICC, IF, IHC, IP, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-KCC2 Monoclonal Antibody, Clone S1-12 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-KCC2 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:200 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) KCC2 Antibody (D) Composite. Western Blot analysis of Rat brain membrane lysate showing detection of KCC2 protein using Mouse Anti-KCC2 Monoclonal Antibody, Clone S1-12 . Primary Antibody: Mouse Anti-KCC2 Monoclonal Antibody  at 1:1000. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
$507.00
Details
Human Maus Biotin ICC, IF, IHC, IP, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-KCC2 Monoclonal Antibody, Clone S1-12 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-KCC2 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:200 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) KCC2 Antibody (D) Composite. Western Blot analysis of Rat brain membrane lysate showing detection of KCC2 protein using Mouse Anti-KCC2 Monoclonal Antibody, Clone S1-12 . Primary Antibody: Mouse Anti-KCC2 Monoclonal Antibody  at 1:1000. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
$509.60
Details
Human Maus PE ICC, IF, IHC, IP, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-KCC2 Monoclonal Antibody, Clone S1-12 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-KCC2 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:200 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) KCC2 Antibody (D) Composite. Western Blot analysis of Rat brain membrane lysate showing detection of KCC2 protein using Mouse Anti-KCC2 Monoclonal Antibody, Clone S1-12 . Primary Antibody: Mouse Anti-KCC2 Monoclonal Antibody  at 1:1000. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
$510.90
Details
Human Maus Streptavidin ICC, IF, IHC, IP, WB Immunocytochemistry/Immunofluorescence analysis using Mouse Anti-KCC2 Monoclonal Antibody, Clone S1-12 . Tissue: Neuroblastoma cell line (SK-N-BE). Species: Human. Fixation: 4% Formaldehyde for 15 min at RT. Primary Antibody: Mouse Anti-KCC2 Monoclonal Antibody  at 1:100 for 60 min at RT. Secondary Antibody: Goat Anti-Mouse ATTO 488 at 1:200 for 60 min at RT. Counterstain: Phalloidin Texas Red F-Actin stain; DAPI (blue) nuclear stain at 1:1000, 1:5000 for 60 min at RT, 5 min at RT. Localization: Membrane. Magnification: 60X. (A) DAPI (blue) nuclear stain (B) Phalloidin Texas Red F-Actin stain (C) KCC2 Antibody (D) Composite. Western Blot analysis of Rat brain membrane lysate showing detection of KCC2 protein using Mouse Anti-KCC2 Monoclonal Antibody, Clone S1-12 . Primary Antibody: Mouse Anti-KCC2 Monoclonal Antibody  at 1:1000. 100 μg Anmelden zum Anzeigen 3 bis 4 Tage
$512.20
Details

Am meisten referenzierte anti-Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 Antikörper

  1. Mammalian Monoclonal SLC12A5 Primary Antibody für ISt, IHC - ABIN1304723 : Lee, Walker, Williams, Goodier, Payne, Moss: Direct protein kinase C-dependent phosphorylation regulates the cell surface stability and activity of the potassium chloride cotransporter KCC2. in The Journal of biological chemistry 2007 (PubMed)
    Show all 11 Pubmed References

  2. Mammalian Monoclonal SLC12A5 Primary Antibody für ISt, IHC - ABIN1304724 : Law, Paquet, Kania: Emergence of motor circuit activity. in PLoS ONE 2014 (PubMed)

Weitere Antikörper gegen Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 Interaktionspartner

Human Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) Interaktionspartner

  1. the long-time considered "neuron-specific" KCC2 co-transporter is expressed in pancreatic islet beta-cells where it modulates Ca(2+)-dependent insulin secretion.

  2. These data clearly demonstrated that partially disrupted neuronal Cl(-) extrusion, mediated by two types of differentially impaired KCC2 mutant in an individual, causes epilepsy of infancy with migrating focal seizures.

  3. Study describes the developmental patterns of cation-chloride cotransporters in the human brain from the fetal stage to senescence. Expression of KCC2 and its functionally associated proteins begins in early fetal period.

  4. The authors show that APP can physically interact with KCC2, a neuron-specific K(+)-Cl(-) cotransporter that is essential for Cl(-) homeostasis and fast GABAergic inhibition.

  5. SLC12A5 promoted the migration and invasion of BUC by enhancing MMP-7 expression.

  6. Study shows that the overall expression of potassium-chloride cotransporter-2 is increased in the hippocampi of temporal lobe epilepsy patients.

  7. Our network model suggested the loss of KCC2 in a critical number of pyramidal cells increased external potassium and intracellular chloride concentrations leading to seizure-like field potential oscillations. These oscillations included transient discharges leading to ictal-like field events with frequency spectra as in vitro Restoration of KCC2 function suppressed seizure activity and thus may present a useful therapeut

  8. The KCC2 exerts specific functions for the maturation of glycinergic synapses in cultured spinal cord neurons.

  9. SLC12A5 plays a pivotal oncogenic role in colorectal carcinogenesis; its overexpression is an independent prognostic factor of patients with CRC.

  10. the functional deficit of KCC2 may offer an explanation for the delayed onset of Rett symptoms.

  11. A KCC2 mutation causes epilepsy of infancy with migrating focal seizures. Decreased KCC2 expression, reduced protein glycosylation and impaired Cl- extrusion contribute to loss of KCC2 activity, impairing synaptic inhibition and promoting excitability.

  12. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  13. a novel signaling pathway that couples KCC2 to the cytoskeleton and regulates the formation of glutamatergic synapses.

  14. These data describe a novel KCC2 variant significantly associated with a human disease and suggest genetically encoded impairment of KCC2 functional regulation may be a risk factor for the development of human IGE.

  15. KCC2-R952H from patients with febrile seizures impairs neuronal Cl- extrusion and dendritic spine formation.

  16. Functional characterization of mutant SLC12A5 revealed its potential oncogenic effect in colon cancer.

  17. Reduced KCC2/NKCC1 ratio in the cerebrospinal fluid of Rett Syndrome patients suggests a disturbed process of GABAergic neuronal maturation and open up a new therapeutic perspective.

  18. Disrupted KCC2 activity seems to be involved in neuropathic pain, epilepsy, motor spasticity, stress and schizophrenia.

  19. BPA can disrupt Kcc2 gene expression through epigenetic mechanisms

  20. Alternate transcripts from KCC2 may participate in the abnormal GABA signaling in the dorsolateral prefrontal cortex associated with schizophrenia

Mouse (Murine) Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) Interaktionspartner

  1. Enhancing GABAAR-mediated inhibition confines KCC2 to the plasma membrane, while antagonizing inhibition reduces KCC2 surface expression by increasing the lateral diffusion and endocytosis of the transporter.

  2. the long-time considered "neuron-specific" KCC2 co-transporter is expressed in pancreatic islet beta-cells where it modulates Ca(2+)-dependent insulin secretion.

  3. increase in KCC2 function mitigated induction of aberrant high-frequency activity during seizures, highlighting depolarizing GABA as a key contributor to the pathological neuronal synchronization seen in epilepsy.

  4. our results demonstrate that local deficits in KCC2 activity within the hippocampus are sufficient to precipitate Mesial temporal lobe epilepsy .

  5. Results demonstrate that KCC2 downregulation preceded convulsant induced epileptiform bursting activities both in vitro and in vivo. Suppression of its membrane expression induced spontaneous epileptiform bursting activities in vitro and Racine III seizure behaviors accompanied by epileptic EEG in vivo.

  6. Disruption of Kcc2-dependent inhibition of olfactory bulb output neurons suggests its importance in odor discrimination.

  7. Study provides evidence for a proconvulsive role of GABAA receptor signaling that depends on the involvement of the KCC2 co-transporter.

  8. Overall, the global native-KCC2 interactome and subsequent characterization revealed PACSIN1 as a novel and potent negative regulator of KCC2.

  9. This study directly implicates the dephosphorylation and downregulation of KCC2 in the peritumoral brain region in the pathophysiology of tumor-associated epilepsy in disease model mice; proposes that glutamate release from glioma cells mediate the dephosphorylation and downregulation of KCC2, revealing yet another target for the treatment of tumor-associated epilepsies.

  10. Study showed that there is a transient dysregulation in the levels of NKCC1 and KCC2 at disease onset, the time point when heightened nociceptive behaviors are most pronounced in mice with experimental autoimmune encephalomyelitis.

  11. Neonatal maternal separation leads to KCC2 expression inhibition persisting until adolescence in hippocampus.

  12. TGF-beta2 is a new regulatory factor for KCC2 functional activation and membrane trafficking.

  13. GABAA receptor (GABAAR) and the Na(+)-K(+)-2Cl(-) cotransporter (NKCC1), but not the K(+)-Cl(-) cotransporter (KCC2), were expressed in the terminals of the CRH neurons at the median eminence (ME). In contrast, CRH neuronal somata were enriched with KCC2 but not with NKCC1.

  14. GluK2-mediated increase in KCC2 recycling to the surface membrane translates to a hyperpolarization of the reversal potential for GABA (EGABA).

  15. KCC2 expression supersedes NKCC1 in mature fiber cells in mouse and rabbit lenses.

  16. these data provide insight into the mechanism regulating Cl(-) homeostasis in immature neurons, and suggest that WNK1-regulated changes in KCC2 phosphorylation contribute to the developmental excitatory-to-inhibitory GABA sequence.

  17. Repeated stress decreased KCC2 expression and increased NKCC1 expression in membranes of granular and pyramidal cells in the hippocampus.

  18. Decreasing [Cl(-)]i levels caused by increasing KCC2 levels in the 12 N could play important roles in regulating the frequency of respiration-related rhythmic activity during development.

  19. Results showed that the fast functional up-regulation of KCC2 in the mouse hippocampus following neonatal status epilepticus is dependent on BDNF

  20. In these neurons, the plasmalemmal expression of KCC2, which establishes the low [Cl(-) ]i required for GABAA R-mediated inhibition

Solute Carrier Family 12 (Potassium-Chloride Transporter) Member 5 (SLC12A5) Antigen-Profil

Protein Überblick

K-Cl cotransporters are proteins that lower intracellular chloride concentrations below the electrochemical equilibrium potential. The protein encoded by this gene is an integral membrane K-Cl cotransporter that can function in either a net efflux or influx pathway, depending on the chemical concentration gradients of potassium and chloride. The encoded protein can act as a homomultimer, or as a heteromultimer with other K-Cl cotransporters, to maintain chloride homeostasis in neurons. Alternative splicing results in two transcript variants encoding different isoforms.

Genbezeichner und Symbole assoziert mit SLC12A5

  • solute carrier family 12 member 5 (SLC12A5) Antikörper
  • solute carrier family 12 member 5 (Slc12a5) Antikörper
  • solute carrier family 12, member 5 (Slc12a5) Antikörper
  • KCC2 Antikörper
  • mKIAA1176 Antikörper

Bezeichner auf Proteinebene für SLC12A5

solute carrier family 12 (potassium/chloride transporter), member 5 , K-Cl cotransporter 2 , electroneutral potassium-chloride cotransporter 2 , furosemide-sensitive K-Cl cotransporter , neuronal K-Cl cotransporter , neuronal-specific K-Cl cotransporter , rKCC2 , solute carrier family 12 member 5 , solute carrier family 12, member 5 , erythroid K-Cl cotransporter 2 , hKCC2 , mKCC2

GENE ID SPEZIES
100155991 Sus scrofa
171373 Rattus norvegicus
57468 Homo sapiens
57138 Mus musculus
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